Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Pieter Annaert"'
Autor:
Martje Van Neste, Nina Nauwelaerts, Michael Ceulemans, Benedikte Cuppers, Pieter Annaert, Anne Smits, Karel Allegaert
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
IntroductionWhile breastfeeding is recommended, knowledge regarding medicine transfer to human milk and its safety for nursing infants is limited. Only one paper has previously described dimethyl fumarate (DMF) transfer during breastfeeding in two pa
Externí odkaz:
https://doaj.org/article/be205e8a7a584159a14123745e40047a
Autor:
Karel Allegaert, Anne Smits, Kristel Van Calsteren, Pieter Annaert, An Eerdekens, Martje Van Neste, Nina Nauwelaerts, Michael Ceulemans
Publikováno v:
BMJ Paediatrics Open, Vol 8, Iss 1 (2024)
Introduction Breastfeeding is beneficial for the health of the mother and child. However, at least 50% of postpartum women need pharmacotherapy, and this number is rising due to the increasing prevalence of chronic diseases and pregnancies at a later
Externí odkaz:
https://doaj.org/article/5487581855704e0c8a5088a69a4388c6
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 128 (2024)
This commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world d
Externí odkaz:
https://doaj.org/article/babb958d9cdd43d3a728bd820082bef0
Autor:
Marina-Stefania Stroe, Lieselotte Van Bockstal, Allan Valenzuela, Miriam Ayuso, Karen Leys, Pieter Annaert, Sebastien Carpentier, Anne Smits, Karel Allegaert, Adrian Zeltner, Antonius Mulder, Chris Van Ginneken, Steven Van Cruchten
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Animal models provide useful information on mechanisms in human disease conditions, but also on exploring (patho)physiological factors affecting pharmacokinetics, safety, and efficacy of drugs in development. Also, in pediatric patients, nonclinical
Externí odkaz:
https://doaj.org/article/ac7f71c6c71e4a1191bda026066e9390
Autor:
Martje Van Neste, Annick Bogaerts, Nina Nauwelaerts, Julia Macente, Anne Smits, Pieter Annaert, Karel Allegaert
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2618 (2023)
Physiologically based pharmacokinetic (PBPK) modelling is a bottom-up approach to predict pharmacokinetics in specific populations based on population-specific and medicine-specific data. Using an illustrative approach, this review aims to highlight
Externí odkaz:
https://doaj.org/article/55f041a90eed4c7d9fe93ac47b0566b6
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 348-361 (2022)
Abstract Before investing resources into the development of a precision dosing (model‐informed precision dosing [MIPD]) tool for tacrolimus, the performance of the tool was evaluated in silico. A retrospective dataset of 315 de novo kidney transpla
Externí odkaz:
https://doaj.org/article/771e2ce1da574f3791df4931f5bf3f10
Autor:
Julia Macente, Nina Nauwelaerts, Francesca M. Russo, Jan Deprest, Karel Allegaert, Bart Lammens, Rodolfo Hernandes Bonan, Jessica M. Turner, Sailesh Kumar, Andrea Diniz, Frederico S. Martins, Pieter Annaert
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Sildenafil is a potent vasodilator and phosphodiesterase type five inhibitor, commercially known as Revatio® and approved for the treatment of pulmonary arterial hypertension. Maternal administration of sildenafil during pregnancy is being evaluated
Externí odkaz:
https://doaj.org/article/8ad98c4598d14cb5a091940804d0bb02
Autor:
Marlly Guarin, Ruben Faelens, Arianna Giusti, Noémie De Croze, Marc Léonard, Deirdre Cabooter, Pieter Annaert, Peter de Witte, Annelii Ny
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Zebrafish (Danio rerio) is increasingly used to assess the pharmacological activity and toxicity of compounds. The spatiotemporal distribution of seven fluorescent alkyne compounds was examined during 48 h after immersion (10 µM) or microin
Externí odkaz:
https://doaj.org/article/0eddd8ab3b4f47fd9557c755447ca0c1
Autor:
Nina Nauwelaerts, Julia Macente, Neel Deferm, Rodolfo Hernandes Bonan, Miao-Chan Huang, Martje Van Neste, David Bibi, Justine Badee, Frederico S. Martins, Anne Smits, Karel Allegaert, Thomas Bouillon, Pieter Annaert
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1469 (2023)
Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacok
Externí odkaz:
https://doaj.org/article/11f1b5bd790e446a9b2a3b6512657899
Autor:
Bianca D. vanGroen, Venkatesh Pilla Reddy, Justine Badée, Andrés Olivares‐Morales, Trevor N. Johnson, Johan Nicolaï, Pieter Annaert, Anne Smits, Saskia N. deWildt, Catherijne A. J. Knibbe, Loeckie deZwart
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 29-35 (2021)
On April 24, 2019, a symposium on Pediatric Pharmacokinetics and Dose Predictions was held as a satellite meeting to the 10th Juvenile Toxicity Symposium. This symposium brought together scientists from academia, industry, and clinical research organ
Externí odkaz:
https://doaj.org/article/690f10a798a64e0ea88774b713cf9363