Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Piet Molenaar"'
Autor:
Ravi S. Narayan, Piet Molenaar, Jian Teng, Fleur M. G. Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C. Lecca, Kristiaan J. Lenos, Sjors G. J. G. In ‘t Veld, Wessel van Wieringen, Frederick F. Lang, Erik Sulman, Roel Verhaak, Brigitta G. Baumert, Lucas J. A. Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J. Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A. Tannous, Tom Wurdinger, Jan Koster, Bart A. Westerman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for explor
Externí odkaz:
https://doaj.org/article/379bf84492484b43b2eac920159ae273
Autor:
Brigitta G. Baumert, Erik P. Sulman, Jan Koster, Rogier Dik, Yoran Broersma, Tonny Lagerweij, Rogier Versteeg, Lucas J A Stalpers, D. P. Noske, Irene Roelofs, Jhon Alexander Marin Soto, Sjors G J G In 't Veld, Peter Sminia, Naomi Petersen, Louis Vermeulen, Maria C. Lecca, Eelke Brands, Ravi S. Narayan, Bakhos A. Tannous, Renée X. de Menezes, David Bailey, Jian Teng, Bart A Westerman, Ben J. Slotman, Thomas Wurdinger, Piet Molenaar, Fleur M G Cornelissen, Roel G.W. Verhaak, Colin Watts, Frederick F. Lang, Kristiaan J. Lenos, Wessel N. van Wieringen, Philip van Kuiken
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, 11(1):2935. Nature Publishing Group
Nature Communications, 11(1):2935
Narayan, R S, Molenaar, P, Teng, J, Cornelissen, F M G, Roelofs, I, Menezes, R, Dik, R, Lagerweij, T, Broersma, Y, Petersen, N, Marin Soto, J A, Brands, E, van Kuiken, P, Lecca, M C, Lenos, K J, Int Veld, S G J G, van Wieringen, W, Lang, F F, Sulman, E, Verhaak, R, Baumert, B G, Stalpers, L J A, Vermeulen, L, Watts, C, Bailey, D, Slotman, B J, Versteeg, R, Noske, D, Sminia, P, Tannous, B A, Wurdinger, T, Koster, J & Westerman, B A 2020, ' A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities ', Nature Communications, vol. 11, no. 1, 2935 . https://doi.org/10.1038/s41467-020-16735-2, https://doi.org/10.1038/s41467-020-16735-2
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, 11(1):2935. Nature Publishing Group
Nature Communications, 11(1):2935
Narayan, R S, Molenaar, P, Teng, J, Cornelissen, F M G, Roelofs, I, Menezes, R, Dik, R, Lagerweij, T, Broersma, Y, Petersen, N, Marin Soto, J A, Brands, E, van Kuiken, P, Lecca, M C, Lenos, K J, Int Veld, S G J G, van Wieringen, W, Lang, F F, Sulman, E, Verhaak, R, Baumert, B G, Stalpers, L J A, Vermeulen, L, Watts, C, Bailey, D, Slotman, B J, Versteeg, R, Noske, D, Sminia, P, Tannous, B A, Wurdinger, T, Koster, J & Westerman, B A 2020, ' A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities ', Nature Communications, vol. 11, no. 1, 2935 . https://doi.org/10.1038/s41467-020-16735-2, https://doi.org/10.1038/s41467-020-16735-2
Personalized cancer treatments using combinations of drugs with a synergistic effect is attractive but proves to be highly challenging. Here we present an approach to uncover the efficacy of drug combinations based on the analysis of mono-drug effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45881133c5d8ff689a4a73ac06a72035
http://europepmc.org/articles/PMC7287046
http://europepmc.org/articles/PMC7287046
Autor:
Bart A. Westerman, Fleur Cornelissen, Jan Koster, Thomas Wurdinger, Ravi S. Narayan, Piet Molenaar
Publikováno v:
Neuro Oncol
Personalized cancer treatments using synergistic combinations of drugs is attractive but proves to be highly challenging. The combinatorial nature of such problems results in an enormous parameter space that cannot be resolved by empirical research,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83b3ae4c5097218387bd338ae60dda0
https://europepmc.org/articles/PMC6847425/
https://europepmc.org/articles/PMC6847425/
Autor:
Gary D. Bader, Trey Ideker, William J.R. Longabaugh, Michael Kucera, Adam Treister, Keiichiro Ono, Eric Sage, Benno Schwikowski, Piet Molenaar, David Otasek, Alexander R. Pico, Barry Demchak, Christian Lopes, Brett Settle, John H. Morris
Publikováno v:
F1000Research
F1000Research, Faculty of 1000, 2018, 7, pp.800. ⟨10.12688/f1000research.15355.1⟩
F1000Research, 2018, 7, pp.800. ⟨10.12688/f1000research.15355.1⟩
F1000Research, Faculty of 1000, 2018, 7, pp.800. ⟨10.12688/f1000research.15355.1⟩
F1000Research, 2018, 7, pp.800. ⟨10.12688/f1000research.15355.1⟩
This article is an Editorial and has not been subject to external peer review; International audience; Cytoscape is the premiere platform for interactive analysis, integration and visualization of network data. While Cytoscape itself delivers much ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245f9be70843631ab69cce683f81a7ad
http://europepmc.org/articles/PMC6013757
http://europepmc.org/articles/PMC6013757
Autor:
Bart A. Westerman, Rogier Versteeg, Arjan Lakeman, Johannes Bras, Peter van Sluis, Aldo Jongejan, Frank Baas, Antoine H. C. van Kampen, Jan J. Molenaar, Linda Koster, Margriet Huizer-Smit, Carel J. M. van Noesel, Nancy E. Hasselt, Danny A. Zwijnenburg, Lianne van Dijk-Kerkhoven, Marloes Broekmans, Mohamed Hamdi, Richard Volckmann, Tim van Groningen, Godelieve A.M. Tytgat, Franciska Haneveld, Natalia E Nowakowska, Linda J. Valentijn, Jan Koster, Nurdan Akogul, Piet Molenaar, Maria C. Lecca, Ellen M. Westerhout, Alvin Chan, Johan van Nes, Marli E. Ebus
Publikováno v:
Nature Genetics, 49(8), 1261
Nature Genetics, 49(8), 1261-1266. Nature Publishing Group
Van Groningen, T, Koster, J, Valentijn, L J, Zwijnenburg, D A, Akogul, N, Hasselt, N E, Broekmans, M, Haneveld, F, Nowakowska, N E, Bras, J, Van Noesel, C J M, Jongejan, A, Van Kampen, A H, Koster, L, Baas, F, Van Dijk-Kerkhoven, L, Huizer-Smit, M, Lecca, M C, Chan, A, Lakeman, A, Molenaar, P, Volckmann, R, Westerhout, E M, Hamdi, M, Van Sluis, P G, Ebus, M E, Molenaar, J J, Tytgat, G A, Westerman, B A, Van Nes, J & Versteeg, R 2017, ' Neuroblastoma is composed of two super-enhancer-associated differentiation states ', Nature Genetics, vol. 49, no. 8, pp. 1261-1266 . https://doi.org/10.1038/ng.3899
Nature genetics, 49(8), 1261-1266. Nature Publishing Group
Nature Genetics, 49(8), 1261-1266. Nature Publishing Group
Van Groningen, T, Koster, J, Valentijn, L J, Zwijnenburg, D A, Akogul, N, Hasselt, N E, Broekmans, M, Haneveld, F, Nowakowska, N E, Bras, J, Van Noesel, C J M, Jongejan, A, Van Kampen, A H, Koster, L, Baas, F, Van Dijk-Kerkhoven, L, Huizer-Smit, M, Lecca, M C, Chan, A, Lakeman, A, Molenaar, P, Volckmann, R, Westerhout, E M, Hamdi, M, Van Sluis, P G, Ebus, M E, Molenaar, J J, Tytgat, G A, Westerman, B A, Van Nes, J & Versteeg, R 2017, ' Neuroblastoma is composed of two super-enhancer-associated differentiation states ', Nature Genetics, vol. 49, no. 8, pp. 1261-1266 . https://doi.org/10.1038/ng.3899
Nature genetics, 49(8), 1261-1266. Nature Publishing Group
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from different lineage development s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f05e663859e4d514b96ffa508717332
https://doi.org/10.1038/ng.3899
https://doi.org/10.1038/ng.3899
Publikováno v:
Cancer Research. 79:2490-2490
Given the complexity, omics data like RNA-seq are often analyzed by bioinformaticians, and not the wetlab researchers that performed the experiments. With the biomedical researcher (with limited or no bioinformatics skills) in mind as the end-user, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c5b8a38e02975f0a99a7bb02c5488c7
https://doi.org/10.1158/1538-7445.am2019-2490
https://doi.org/10.1158/1538-7445.am2019-2490
Autor:
Bakhos A. Tannous, Bart A. Westerman, Jian Teng, Piet Molenaar, Thomas Wurdinger, Ravi S. Narayan, Jan Koster
Publikováno v:
Cancer Research. 78:576-576
Personalized cancer treatments using synergistic combinations of drugs is attractive but proves to be highly challenging. The combinatorial nature of such problems results in an enormous parameter space that cannot be resolved by empirical research,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad21f0cdae7579637869f0a4b1a536c
https://doi.org/10.1158/1538-7445.am2018-576
https://doi.org/10.1158/1538-7445.am2018-576
Autor:
Piet Molenaar, Peter Sminia, Jan Koster, Bart A. Westerman, Fleur Cornelissen, Irene Roelofs, Ravi S. Narayan, Thomas Wurdinger
Publikováno v:
Neuro-Oncology. 19:vi74-vi74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496add1cac9e142f1c1a74cd0033b551
https://doi.org/10.1093/neuonc/nox168.302
https://doi.org/10.1093/neuonc/nox168.302
Autor:
Evan E. Santo, Huib N. Caron, Ingrid Øra, Ida van der Ploeg, Linda Schild, Arjan Lakeman, Mohamed Hamdi, Jan Koster, Linda J. Valentijn, Piet Molenaar, Jan J. Molenaar, Danny A. Zwijnenburg, Marli E. Ebus, Peter Stroeken, Jennemiek van Arkel, Ellen M. Westerhout, Peter van Sluis, Johan van Nes, Rogier Versteeg, Max M. van Noesel, Bart A. Westerman, Franciska Haneveld
Publikováno v:
Nature, 483(7391), 589-593. Nature Publishing Group
Molenaar, J J, Koster, J, Zwijnenburg, D A, Van Sluis, P, Valentijn, L J, Van Der Ploeg, I, Hamdi, M, Van Nes, J, Westerman, B A, Van Arkel, J, Ebus, M E, Haneveld, F, Lakeman, A, Schild, L, Molenaar, P, Stroeken, P, Van Noesel, M M, Øra, I, Santo, E E, Caron, H N, Westerhout, E M & Versteeg, R 2012, ' Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes ', Nature, vol. 483, no. 7391, pp. 589-593 . https://doi.org/10.1038/nature10910
Nature, 483. Nature Publishing Group
Nature, 483(7391), 589-U107. Nature Publishing Group
Molenaar, J J, Koster, J, Zwijnenburg, D A, Van Sluis, P, Valentijn, L J, Van Der Ploeg, I, Hamdi, M, Van Nes, J, Westerman, B A, Van Arkel, J, Ebus, M E, Haneveld, F, Lakeman, A, Schild, L, Molenaar, P, Stroeken, P, Van Noesel, M M, Øra, I, Santo, E E, Caron, H N, Westerhout, E M & Versteeg, R 2012, ' Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes ', Nature, vol. 483, no. 7391, pp. 589-593 . https://doi.org/10.1038/nature10910
Nature, 483. Nature Publishing Group
Nature, 483(7391), 589-U107. Nature Publishing Group
Neuroblastomais a childhood tumour of the peripheral sympathetic nervous system. The pathogenesis has for a long time been quite enigmatic, as only very few gene defects were identified in this often lethal tumour(1). Frequently detected gene alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7003cf814d7488759f7efe6c1751846
https://pubmed.ncbi.nlm.nih.gov/22367537
https://pubmed.ncbi.nlm.nih.gov/22367537
Autor:
Trey Ideker, Samad Lotia, Piet Molenaar, David Welker, John H. Morris, Alexander R. Pico, Gary D. Bader, Timothy Hull, Keiichiro Ono, Benno Schwikowski, Barry Demchak, Christian Lopes, Oriol Guitart Pla, William J.R. Longabaugh, Jason Montojo
Publikováno v:
F1000Research
F1000Research, 3. F1000 Research Ltd.
F1000Research, 3. F1000 Research Ltd.
As a network visualization and analysis platform, Cytoscape relies on apps to provide domain-specific features and functions. There are many resources available to support Cytoscape app development and distribution, including the Cytoscape App Store
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe57b29623078fe07a315a23e570531d
https://doi.org/10.12688/f1000research.4642.1
https://doi.org/10.12688/f1000research.4642.1