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Label-free assessment of high-affinity antibody-antigen binding constants. Comparison of bioassay, SPR, and PEIA-ellipsometry

Autor: Theo Rispens, Wim Th. Hermens, Henk te Velthuis, Han Speijer, Piet Hemker, Lucien A. Aarden

Publikováno v: Journal of Immunological Methods, 365(1-2), 50-57
Journal of immunological methods, 365(1-2), 50-57. Elsevier

Assessment of high-affinity antibody-antigen binding parameters is important in such diverse areas as selection of therapeutic antibodies, detection of unwanted hormones in cattle and sensitive immunoassays in clinical chemistry. Label-free assessmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d5328cb9d1638ce9e5da079b7f2e0c
https://doi.org/10.1016/j.jim.2010.11.010

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An hp-adaptive strategy for the solution Of the exact kernel curved wire pocklington Equation

Autor: Piet Hemker, Domenico Lahaye

Publikováno v: Computational Methods in Applied Mathematics, 8(1), 39-59

In this paper we introduce an adaptive method for the numerical solu-tion of the Pocklington integro-differential equation with exact kernel for the current induced in a smoothly curved thin wire antenna. The hp-adaptive technique is based on the rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cd3238b69548267d0fdf6b4a2c9d8e
https://ir.cwi.nl/pub/26564

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A trust-region strategy for manifold-mapping optimization

Autor: Piet Hemker, David Echeverria

Publikováno v: Journal of Computational Physics, 224(1), 464-475

Studying the space-mapping technique by Bandler et al. [J. Bandler, R. Biernacki, S. Chen, P. Grobelny, R.H. Hemmers, Space mapping technique for electromagnetic optimization, IEEE Trans. Microwave Theory Tech. 42 (1994) 2536–2544] for the solution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe50c2c0c26d395ffb4382fa8f1333f9
https://doi.org/10.1016/j.jcp.2007.04.003

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Efficient optimal design of electromagnetic actuators using space mapping

Autor: David Echeverria, L Laurentiu Encica, Piet Hemker, Elena A. Lomonova, Aja André Vandenput, Djp Lahaye

Publikováno v: Structural and Multidisciplinary Optimization, 33(6), 481-491. Springer

Engineering optimization procedures employ highly accurate numerical models that typically have an excessive computational cost, e.g., finite elements (FE). The space mapping (SM) technique speeds up the minimization procedure by exploiting simplifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d41630a426296e199f0e8142e23dfc
https://doi.org/10.1007/s00158-006-0054-6

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Space Mapping and Defect Correction

Autor: Piet Hemker, D. Echeverrĭa

Publikováno v: Computational Methods in Applied Mathematics, 5(2), 107-136

In this paper we show that space-mapping optimization can be understood in the framework of defect correction. Then, space-mapping algorithms can be seen as special cases of defect correction iteration. In order to analyze the properties of space map

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ab919ece032ef54899221278de3f65
https://doi.org/10.2478/cmam-2005-0006

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Optimisation in electromagnetics with the space-mapping technique

Autor: Piet Hemker, Djp Lahaye, David Echeverria, L Laurentiu Encica

Publikováno v: COMPEL: The International Journal for Computation and Mathematics in Electrical and Electronic Engineering, 24(3), 952-966. Emerald Group Publishing Ltd.

PurposeOptimisation in electromagnetics, based on finite element models, is often very time‐consuming. In this paper, we present the space‐mapping (SM) technique which aims at speeding up such procedures by exploiting auxiliary models that are le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ee887624a42442e71dc6a50fdef94e
https://doi.org/10.1108/03321640510598265

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A Class of Singularly Perturbed Convection-Diffusion Problems with a Moving Interior Layer. An a Posteriori Adaptive Mesh Technique

Autor: Grigory Shishkin, Piet Hemker, Lidia P. Shishkina

Publikováno v: Computational Methods in Applied Mathematics. 4:105-127

We study numerical approximations for a class of singularly perturbed convection-diffusion type problems with a moving interior layer. In a domain (segment) with a moving interface between two subdomains, we consider an initial boundary value problem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d40aa77d36443fc56d3f63c69ddcff6
https://doi.org/10.2478/cmam-2004-0007

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Discontinuous Galerkin Discretization with Embedded Boundary Conditions

Autor: Piet Hemker, W. Hoffmann, van Marc Raalte

Publikováno v: Computational Methods in Applied Mathematics. 3:135-158

The purpose of this paper is to introduce discretization methods of discontinuous Galerkin type for solving second-order elliptic PDEs on a structured, regular rectangular grid, while the problem is defined on a curved boundary. The methods aim at hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f9cf0057be35a018b0639cd0513c3a9
https://doi.org/10.2478/cmam-2003-0010

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