Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Piet Gros"'
Autor:
Christina Lamers, Xiaoguang Xue, Martin Smieško, Henri van Son, Bea Wagner, Nadja Berger, Georgia Sfyroera, Piet Gros, John D. Lambris, Daniel Ricklin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Therapeutic modulation of the complement system has gained interest over the past two decades. Here, the authors provide molecular-level insight into the mode-of-action, target selectivity and species specificity of the compstatin family of complemen
Externí odkaz:
https://doaj.org/article/0c7331cff4f34721b958795607a6055b
Autor:
Nicholas M. Pearce, Piet Gros
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here, the authors present a hierarchical disorder model for the analysis of disorder in both crystal and cryo-EM structures. They apply their approach to several structures of three proteins, including SARS-CoV-2 proteins, and discuss mechanistic and
Externí odkaz:
https://doaj.org/article/4f91ff9851374d8cac908210c30b09f1
Publikováno v:
IUCrData, Vol 7, Iss 9, p x220852 (2022)
Remarkable features are reported in the diffraction pattern produced by a crystal of the second extracellular domain of tetraspanin CD9 (deemed CD9EC2), the structure of which has been described previously [Oosterheert et al. (2020), Life Sci. Allian
Externí odkaz:
https://doaj.org/article/62392550b88a4ab39554036b55f4da24
Autor:
Nicola Fenderico, Revina C. van Scherpenzeel, Michael Goldflam, Davide Proverbio, Ingrid Jordens, Tomica Kralj, Sarah Stryeck, Tarek Z. Bass, Guy Hermans, Christopher Ullman, Teodor Aastrup, Piet Gros, Madelon M. Maurice
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHH
Externí odkaz:
https://doaj.org/article/5a4f5bbea0514b429431ef3636e2ef04
Autor:
Wout Oosterheert, Laura S. van Bezouwen, Remco N. P. Rodenburg, Joke Granneman, Friedrich Förster, Andrea Mattevi, Piet Gros
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Enzymes of the six-transmembrane epithelial antigen of the prostate (STEAP) family reduce Fe3+ and Cu2+ ions to facilitate metal-ion uptake by mammalian cells. Here, authors employ single-particle cryo-EM to gain insights into the molecular principle
Externí odkaz:
https://doaj.org/article/0327e5d4fe7d44afad92e8cf690996b4
Autor:
Remco N. P. Rodenburg, Joost Snijder, Michiel van de Waterbeemd, Arie Schouten, Joke Granneman, Albert J. R. Heck, Piet Gros
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Cysteine palmitoylation affects the localization and function of membrane proteins, but its stoichiometry and specificity are not well understood. Here, the authors show that palmitoylation is a stochastic process that depends on the accessibility of
Externí odkaz:
https://doaj.org/article/31d2d794c1834117b8a67cef2fedf804
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the li
Externí odkaz:
https://doaj.org/article/8792bd8f08c94e4a8eb9adeca955bf76
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 1-8 (2016)
Pore formation in membranes is important for mammalian immune defense against invading bacteria. Induced by complement activation, the membrane attack complex (MAC) forms through sequential binding and membrane insertion of C5b6, C7, C8, and C9. Usin
Externí odkaz:
https://doaj.org/article/5e952d1a7c884b60846268471c6cd54c
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Miscarriage is the most common complication of pregnancy. Approximately 1% of couples trying to conceive will experience recurrent miscarriages, defined as three or more consecutive pregnancy losses and many of these cases remain idiopathic. Compleme
Externí odkaz:
https://doaj.org/article/8b4535131e3f4fd5a52c050d30f043dd
Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5
Autor:
Weng Chuan Peng, Wim de Lau, Federico Forneris, Joke C.M. Granneman, Meritxell Huch, Hans Clevers, Piet Gros
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1885-1892 (2013)
Leucine-rich repeat-containing G protein-coupled receptors 4–6 (LGR4–LGR6) are receptors for R-spondins, potent Wnt agonists that exert profound trophic effects on Wnt-driven stem cells compartments. We present crystal structures of a signaling-c
Externí odkaz:
https://doaj.org/article/fc2139a794284f439f9998f7d6de1f5f