Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft.

Autor: Mohiuddin MM; Cardiothoracic Surgery Research Program, NHLBI, NIH, Bethesda, Maryland 20892, USA., Singh AK; Cardiothoracic Surgery Research Program, NHLBI, NIH, Bethesda, Maryland 20892, USA., Corcoran PC; Cardiothoracic Surgery Research Program, NHLBI, NIH, Bethesda, Maryland 20892, USA., Thomas Iii ML; Division of Veterinary Resources, ORS, NIH, Bethesda, Maryland 20892, USA., Clark T; NICHD/NIH, Bethesda, Maryland 20892, USA., Lewis BG; Division of Veterinary Resources, ORS, NIH, Bethesda, Maryland 20892, USA., Hoyt RF; Leidos Biomedical Research, Inc., Bethesda, Maryland 20892, USA., Eckhaus M; Division of Veterinary Resources, ORS, NIH, Bethesda, Maryland 20892, USA., Pierson Iii RN; University of Maryland Medical Center, Baltimore, Maryland 20201, USA., Belli AJ; MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts 02126, USA., Wolf E; Ludwig Maximilian University, Munich 81377, Germany., Klymiuk N; Ludwig Maximilian University, Munich 81377, Germany., Phelps C; Revivicor Inc., Blacksburg, Virginia 24060, USA., Reimann KA; MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts 02126, USA., Ayares D; Revivicor Inc., Blacksburg, Virginia 24060, USA., Horvath KA; Cardiothoracic Surgery Research Program, NHLBI, NIH, Bethesda, Maryland 20892, USA.

Publikováno v: Nature communications [Nat Commun] 2016 Apr 05; Vol. 7, pp. 11138. Date of Electronic Publication: 2016 Apr 05.