Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Piers Ruddle"'
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 516-523 (2014)
Adipose tissue contains one of the largest reservoirs of cholesterol in the body. Adipocyte dysfunction in obesity is associated with intracellular cholesterol accumulation, and alterations in cholesterol homeostasis have been shown to alter glucose
Externí odkaz:
https://doaj.org/article/df1341111c024edaa402c96b9fa05fe5
Autor:
Joanna M. Karasinska, Willeke de Haan, Sonia Franciosi, Piers Ruddle, Jianjia Fan, Janine K. Kruit, Sophie Stukas, Dieter Lütjohann, David H. Gutmann, Cheryl L. Wellington, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 54, Iss , Pp 445-455 (2013)
ATP-binding cassette transporter A1 (ABCA1) mediates cellular cholesterol efflux in the brain and influences whole brain cholesterol homeostasis. Activation of liver X receptors (LXRs), transcription factors that increase the expression of cholestero
Externí odkaz:
https://doaj.org/article/3dc3c252ec2147fcbb40237917fdac8e
Autor:
Marcia L.E. MacDonald, Roshni R. Singaraja, Nagat Bissada, Piers Ruddle, Russell Watts, Joanna M. Karasinska, William T. Gibson, Catherine Fievet, Jean E. Vance, Bart Staels, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 217-229 (2008)
A combination of the interrelated metabolic risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the “metabolic syndrome,” is known to increase the risk of developing cardiovascular disease and diabetes. St
Externí odkaz:
https://doaj.org/article/17a351d051934869b33eaae8b8be0504
Publikováno v:
Diabetes. 63:4076-4082
Low HDL is a risk factor for the development of type 2 diabetes. Hepatic ABCA1 is the rate-limiting protein in HDL biogenesis, and mice lacking hepatic ABCA1 (ABCA1-l/-l) have very low plasma HDL concentrations. To investigate the role of hepatic ABC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221d0685c9f1d669df43d9a9e13e9b8d
https://doi.org/10.2337/db14-0548
https://doi.org/10.2337/db14-0548
Autor:
Jay V. Patankar, Michael R. Hayden, Piers Ruddle, Albert K. Groen, Nadeeja Wijesekara, Roshni R. Singaraja, Achint Kaur, Willeke de Haan, C. Bruce Verchere
Publikováno v:
Diabetes, 64(4), 1168-1179. AMER DIABETES ASSOC
Besides their role in facilitating lipid absorption, bile acids are increasingly being recognized as signaling molecules that activate cell-signaling receptors. Targeted disruption of the sterol 12α-hydroxylase gene (Cyp8b1) results in complete abse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0763c5af0cd467a9bf078a7b9368d28
https://doi.org/10.2337/db14-0716
https://doi.org/10.2337/db14-0716
Autor:
Sophie Stukas, Janine K. Kruit, Jianjia Fan, Dieter Lütjohann, Sonia Franciosi, Joanna M. Karasinska, Piers Ruddle, Willeke de Haan, Cheryl L. Wellington, David H. Gutmann, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 54, Iss, Pp 445-455 (2013)
ATP-binding cassette transporter A1 (ABCA1) mediates cellular cholesterol efflux in the brain and influences whole brain cholesterol homeostasis. Activation of liver X receptors (LXRs), transcription factors that increase the expression of cholestero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e69f79a0a91709f17c0e051b2177e7b
https://doi.org/10.1016/j.nbd.2013.01.018
https://doi.org/10.1016/j.nbd.2013.01.018
Autor:
Piers Ruddle, Michael R. Hayden, Bart Staels, Russell Watts, Catherine Fievet, Roshni R. Singaraja, Jean E. Vance, William T. Gibson, Nagat Bissada, Marcia L.E. MacDonald, Joanna M. Karasinska
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 217-229 (2008)
A combination of the interrelated metabolic risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the "metabolic syndrome," is known to increase the risk of developing cardiovascular disease and diabetes. Stearo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3ec08d3cdd64bfbaf4d72c218d26a1
https://doi.org/10.1194/jlr.m700478-jlr200
https://doi.org/10.1194/jlr.m700478-jlr200
Autor:
Michael E. Weale, David M. Hunt, David Goldstein, Anna C. Need, Piers Ruddle, Curtis Gumbs, Anthony T. Moore, Susan E. Wilkie, Sarah E. Harris, Ian J. Deary, John M. Starr, Nicole M. Walley, Lawrence J. Whalley, Michel Michaelides, Dianne Gerrelli, Sanjay M. Sisodiya, Pamela J. Thompson, Samantha L. Free
Publikováno v:
Journal of Medical Genetics. 44:373-380
Background: The genetic basis of variation in human cognitive abilities is poorly understood. RIMS1 encodes a synapse active-zone protein with important roles in the maintenance of normal synaptic function: mice lacking this protein have greatly redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ceb0cd329e97f54e0696b2f84955cb
https://doi.org/10.1136/jmg.2006.047407
https://doi.org/10.1136/jmg.2006.047407
Autor:
Martin H. Kang, Blair R. Leavitt, Michael R. Hayden, Colúm Connolly, Achint Kaur, Poul H. Sorensen, Willeke de Haan, Joanna M. Karasinska, Asad Jan, Piers Ruddle
Publikováno v:
Neuroscience letters. 598
The ATP-binding cassette transporter A1 (ABCA1) is a membrane bound protein that serves to efflux cholesterol and phospholipids onto lipid poor apolipoproteins during HDL biogenesis. Increasing the expression and activity of ABCA1 have beneficial eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90908c18ce30d9cfdc73c2ffc8769b3a
https://pubmed.ncbi.nlm.nih.gov/25957561
https://pubmed.ncbi.nlm.nih.gov/25957561
Autor:
Rosalind H.M. King, Piers Ruddle, L Lawrence, Clare Huxley, Sahar Al-Mahdawi, Mark A. Pook, Susan Chamberlain, Margaret B. Lowrie, Cemal K. Cemal, Christopher Carroll
Publikováno v:
Human Molecular Genetics. 11:1075-1094
Machado-Joseph disease (MJD; MIM 109150) is a late-onset neurodegenerative disorder caused by the expansion of a polyglutamine tract within the MJD1 gene. We have previously reported the generation of human yeast artificial chromosome (YAC) construct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959d26e6da5081897dff462521b24568
https://doi.org/10.1093/hmg/11.9.1075
https://doi.org/10.1093/hmg/11.9.1075