Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

Autor: Stefan Antonowicz, Zsolt Bodai, Tom Wiggins, Sheraz R. Markar, Piers R. Boshier, Yan Mei Goh, Mina E. Adam, Haonan Lu, Hiromi Kudo, Francesca Rosini, Robert Goldin, Daniela Moralli, Catherine M. Green, Chris J. Peters, Nagy Habib, Hani Gabra, Rebecca C. Fitzgerald, Zoltan Takats, George B. Hanna

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Volatile aldehydes can be enriched in esophageal adenocarcinoma patients’ breath. Here, the authors reveal corresponding metabolic changes in EAC tumours, which may be caused by impaired detoxification of endogenous metabolites.

Externí odkaz: https://doaj.org/article/c4cb39fcd5d245a5814461336da92aeb

Influence of body composition and muscle strength on outcomes after multimodal oesophageal cancer treatment

Autor: Eliza R.C. Hagens, Minke L. Feenstra, Maarten A. vanEgmond, Hanneke W.M. vanLaarhoven, Maarten C.C.M. Hulshof, Piers R. Boshier, Donald E. Low, Mark I. vanBerge Henegouwen, Suzanne S. Gisbertz

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 3, Pp 756-767 (2020)

Abstract Background Influence of sarcopenia in combination with other body composition parameters and muscle strength on outcomes after oesophageal surgery for oesophageal cancer remains unclear. The objectives were (i) to describe the incidence of s

Externí odkaz: https://doaj.org/article/1975b0b9fcb34bffb38d645ab810431c

Pressurized intraperitoneal aerosol chemotherapy (PIPAC): updated systematic review using the IDEAL framework

Autor: Alice E Baggaley, Guillaume B R C Lafaurie, Sophia J Tate, Piers R Boshier, Amy Case, Susan Prosser, Jared Torkington, Sadie E F Jones, Sarah H Gwynne, Christopher J Peters

Publikováno v: British Journal of Surgery. 110:10-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a6ea3b08d5de6b40406ab1907a821a
https://doi.org/10.1093/bjs/znac284

Development of a Reliable Surgical Quality Assurance System for 2-stage Esophagectomy in Randomized Controlled Trials

Autor: Alexander Harris, Simon Law, Giovanni Zaninotto, Kerry N L Avery, Chi-Chuan Yeh, George B. Hanna, Donald E. Low, Masanori Tokunaga, Hideki Sunagawa, Richard H. Hardwick, Sameh Mikhail, Arnulf H. Hoelscher, Piers R. Boshier, Manuel Pera, Natalie S Blencowe, Melody Ni, J. Jan B. van Lanschot, Hugh Mackenzie, Jane M Blazeby, Richard G. Berrisford, CP Barham, Stella Mavroveli, James William Butterworth

Publikováno v: Harris, A, Butterworth, J, Boshier, P R, MacKenzie, H, Tokunaga, M, Sunagawa, H, Mavroveli, S, Ni, M, Mikhail, S, Yeh, C-C, Blencowe, N S, Avery, K N L, Hardwick, R, Hoelscher, A, Pera, M, Zaninotto, G, Law, S, Low, D E, van Lanschot, J J B, Berrisford, R, Barham, C P, Blazeby, J M & Hanna, G B 2022, ' Development of a Reliable Surgical Quality Assurance System for 2-stage Esophagectomy in Randomized Controlled Trials ', Annals of Surgery, vol. 275, no. 1, pp. 121-130 . https://doi.org/10.1097/SLA.0000000000003850
Annals of Surgery, 275(1), 121-130. Lippincott Williams & Wilkins

OBJECTIVE: The aim was to develop a reliable surgical quality assurance system for 2-stage esophagectomy. This development was conducted during the pilot phase of the multicenter ROMIO trial, collaborating with international experts.SUMMARY OF BACKGR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4485577ed0fc245a9e85b07c1eb86b37
https://doi.org/10.1097/SLA.0000000000003850

Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath

Autor: George B. Hanna, Piers R. Boshier, Bhamini Vadhwana, Ilaria Belluomo, Sheraz R. Markar, Patrik Spanel, Antonis Myridakis

Publikováno v: Nature Protocols. 16:3419-3438

The analysis of volatile organic compounds (VOCs) within breath for noninvasive disease detection and monitoring is an emergent research field that has the potential to reshape current clinical practice. However, adoption of breath testing has been l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da047463b5e823e3758d1f79c25a4fcb
https://doi.org/10.1038/s41596-021-00542-0