Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Piers C. Emson"'
Publikováno v:
Neuroscience. 169:1462-1472
Vomeronasal neurons undergo continuous neurogenesis throughout development and adult life. These neurons originate as stem cells in the apical zone of the lumen of the vomeronasal organ (VNO) and are described as nestin-expressing glia-like progenito
Autor:
Julian L. Griffin, Jing Xia, Reza M. Salek, Piers C. Emson, Robert Adalbert, Brian C. Sweatman, Amy E. Innes, Suzanne Randle, Eileen McGowan
Publikováno v:
Neurochemistry International. 56:937-947
Alzheimer's disease is the most common neurodegenerative disease of the central nervous system characterized by a progressive loss in memory and deterioration of cognitive functions. In this study the transgenic mouse TgCRND8, which encodes a mutant
Publikováno v:
The Journal of Comparative Neurology
The role of cellular phosphatidylinositol 5-phosphate (PtdIns5P), as a signalling molecule or as a substrate for the production of small, compartmentalized pools of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], may be dependent on cell type
Publikováno v:
American Journal of Physiology-Renal Physiology
PIP4Ks (type II phosphatidylinositol 4-phosphate kinases) are phosphatidylinositol 5-phosphate (PtdIns5P) 4-kinases, believed primarily to regulate cellular PtdIns5P levels. In this study, we investigated the expression, localization, and associated
Publikováno v:
Journal of Neurochemistry. 79:564-575
There is extensive experimental evidence indicating a crucial role for glutamate in epileptogenesis and epileptic activity. The glial glutamate transporters GLT1 and GLAST are proposed to account for the majority of extracellular glutamate re-uptake.
Autor:
Henry J. Waldvogel, Andrew B. West, Ted M. Dawson, Shinji Higashi, Heii Arai, Richard L.M. Faull, Piers C. Emson, Darren J. Moore, Saskia Biskup, Daniel B. Trinkaus, Valina L. Dawson
Publikováno v:
Brain Research. 1155:208-219
Mutations in the LRRK2 gene cause autosomal dominant, late-onset parkinsonism, which presents with pleomorphic pathology including alpha-synucleopathy. To promote our understanding of the biological role of LRRK2 in the brain we examined the distribu
Autor:
Sarah L. Lambourne, Trevor Humby, Maria Grazia Spillantini, Lawrence Stephen Wilkinson, Anthony Roger Isles, Piers C. Emson
Publikováno v:
Human Molecular Genetics. 16:1708-1719
Abnormalities in microtubule-associated tau protein are a key neuropathological feature of both Alzheimer's disease and many frontotemporal dementias (FTDs), including hereditary FTD with Parkinsonism linked to chromosome 17 (FTDP-17). In these disor
Autor:
Darren J. Moore, Rebecca E. Colebrooke, Valina L. Dawson, Saskia Biskup, Shinji Higashi, Piers C. Emson, Heii Arai, Ted M. Dawson
Publikováno v:
Journal of Neurochemistry. 100:368-381
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) have been identified as the cause of familial Parkinson's disease (PD) at the PARK8 locus. To begin to understand the physiological role of LRRK2 and its involvement in PD, we have i
Autor:
Jing Xia, Patrick J. Lynch, Piers C. Emson, Trevor Humby, Daniel P. McGowan, Rebecca E. Colebrooke
Publikováno v:
European Journal of Neuroscience. 24:2622-2630
Dopamine cytotoxicity is thought to contribute towards the selective loss of substantia nigra pars compacta dopamine neurons and disease progression in Parkinson's disease. However, the long-term toxicity of dopamine in vivo has not previously been e
Autor:
Piers C. Emson, Sarah L. Lambourne, Lynda A. Sellers, Lawrence Stephen Wilkinson, Toby G. Bush, Yoo-Hun Suh, Shewly K. Choudhury
Publikováno v:
Molecular and Cellular Biology. 25:278-293
Abnormal tau phosphorylation occurs in several neurodegenerative disorders, including Alzheimer's disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). Here, we compare mechanisms of tau phosphorylation in mous