Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Piers A. Hemsley"'
Autor:
Anna Veprik, Geoffrey Denwood, Dong Liu, Rula Bany Bakar, Valentin Morfin, Kara McHugh, Nchimunya N. Tebeka, Laurène Vetterli, Ekaterina Yonova-Doing, Fiona Gribble, Frank Reimann, Kyle L. Hoehn, Piers A. Hemsley, Jonas Ahnfelt-Rønne, Patrik Rorsman, Quan Zhang, Heidi de Wet, James Cantley
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Veprik et al. show that Acetyl-CoA-carboxylase 1 (ACC1), an enzyme that couples glucose metabolism to lipogenesis, is involved in glucagon secretion and regulates S-acylation of critical glucose-sensing proteins. Loss of ACC1 in pancreatic alpha-cell
Externí odkaz:
https://doaj.org/article/166afa66325d42c88ebcf56718483f72
Publikováno v:
BioTechniques, Vol 62, Iss 2, Pp 69-75 (2017)
S-palmitoylation (S-acylation) is emerging as an important dynamic post-translational modification of cysteine residues within proteins. Current assays for protein S-palmitoylation involve either in vivo labeling or chemical cleavage of S-palmitoyl g
Externí odkaz:
https://doaj.org/article/314315093c43443bbafe979ff037d8cc
Publikováno v:
Journal of Proteome Research.
Autor:
Charlotte H. Hurst, Dionne Turnbull, Kaltra Xhelilaj, Sally Myles, Robin L. Pflughaupt, Michaela Kopischke, Paul Davies, Susan Jones, Silke Robatzek, Cyril Zipfel, Julien Gronnier, Piers A. Hemsley
Plant receptor kinases are key transducers of extracellular stimuli, such as the presence of beneficial or pathogenic microbes or secreted signaling molecules. Receptor kinases are regulated by numerous post-translational modifications.1,2,3 Here, us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30aae23269ac572fbaf969ea678dbb1
https://doi.org/10.5167/uzh-233956
https://doi.org/10.5167/uzh-233956
Autor:
Haixia Wang, Shumei Wang, Wei Wang, Lin Xu, Lydia R J Welsh, Marek Gierlinski, Stephen C Whisson, Piers A Hemsley, Petra C Boevink, Paul R J Birch
Publikováno v:
The Plant Cell.
Filamentous (oomycete and fungal) plant pathogens deliver cytoplasmic effector proteins into host cells to facilitate disease. How RXLR effectors from the potato late blight pathogen Phytophthora infestans enter host cells is unknown. One possible ro
Tools have been created to generate in silico proteome digests with different protease enzymes and provide useful information for selecting optimal digest schemes for specific needs. This can save on time and resources and generate insights on the ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb077e9565c8bc4d070ef5c84b49a987
https://doi.org/10.1101/2021.09.02.458698
https://doi.org/10.1101/2021.09.02.458698
Autor:
Dionne Turnbull, Sally M Myles, Charlotte H. Hurst, Julien Gronnier, Susan Jones, Piers A. Hemsley, Cyril Zipfel, Paul Davies, Silke Robatzek, Michaela Kopischke, Robin L. Pflughaupt
SummaryPlant receptor kinases are key transducers of extracellular stimuli, such as the presence of beneficial or pathogenic microbes or secreted signalling molecules. Receptor kinases are regulated by numerous post-translational modifications. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7d0d3f3a3ef8939f784f646a4ed9120
https://doi.org/10.1101/2021.08.30.457756
https://doi.org/10.1101/2021.08.30.457756
Autor:
Susan Jones, Dionne Turnbull, Kerry Leslie, Charlotte H. Hurst, Kathryn M. Wright, Piers A. Hemsley
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
This work was funded by UK Biotechnology and Biological Sciences Research Council Grants BB/M024911/1 and BB/M010996/1 to P.A.H. S-acylation is a common post-translational modification of membrane protein cysteine residues with many regulatory roles.
Autor:
Haixia Wang, Susan Breen, Lydia Welsh, Lina Yang, Marek Malec, Piers A. Hemsley, Eleanor M. Gilroy, Paul R. J. Birch, Tian Zhendong, Shaista Naqvi, Dionne Turnbull, Frédéric Brunner
Publikováno v:
Plant Physiology. 180:571-581
To be successful plant pathogens, microbes use “effector proteins” to manipulate host functions to their benefit. Identifying host targets of effector proteins and characterizing their role in the infection process allow us to better understand p
Autor:
Piers A. Hemsley
Publikováno v:
Biochemical Society transactions. 48(2)
S-acylation is a common yet poorly understood fatty acid-based post-translational modification of proteins in all eukaryotes, including plants. While exact roles for S-acylation in protein function are largely unknown the reversibility of S-acylation