Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Pierre-Yves Desprez"'
Autor:
Vladimir Bezrookove, Imran Khan, Anukana Bhattacharjee, Juifang Fan, Robyn Jones, Anima Sharma, Mehdi Nosrati, Pierre-Yves Desprez, Nathan Salomonis, Yihui Shi, Altaf Dar, Mohammed Kashani-Sabet
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background While melanomas commonly harbor losses of 9p21, on which CDKN2A resides, the presence of additional tumor suppressor elements at this locus is incompletely characterized. Here we assess the expression levels and functional role of
Externí odkaz:
https://doaj.org/article/513c9ed367c241b5a663496b955e253d
Autor:
Aleksandr Udalov, Lexman Kumar, Anna N. Gaudette, Ran Zhang, Joao Salomao, Sanjay Saigal, Mehdi Nosrati, Sean D. McAllister, Pierre-Yves Desprez
Publikováno v:
Methods and Protocols, Vol 6, Iss 3, p 46 (2023)
The longitudinal monitoring of patient circulating tumor DNA (ctDNA) provides a powerful method for tracking the progression, remission, and recurrence of several types of cancer. Often, clinical and research approaches involve the manual review of i
Externí odkaz:
https://doaj.org/article/4bf9ae7434564865a083b791a99b98c6
Publikováno v:
Immunity & Ageing, Vol 17, Iss 1, Pp 1-9 (2020)
Abstract Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue
Externí odkaz:
https://doaj.org/article/d67e0d37246a4efc8e6a515fd9bba0e3
Autor:
Jacob Rose, Nathan Basisty, Tiffany Zee, Cameron Wehrfritz, Neelanjan Bose, Pierre-Yves Desprez, Pankaj Kapahi, Marshall Stoller, Birgit Schilling
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0250137 (2022)
Cystinuria is one of various disorders that cause biomineralization in the urinary system, including bladder stone formation in humans. It is most prevalent in children and adolescents and more aggressive in males. There is no cure, and only limited
Externí odkaz:
https://doaj.org/article/09cabd0021514b83860dac1d85d0c647
Autor:
Maxim Sidorov, Pratiksha Dighe, Rinette W. L. Woo, Aida Rodriguez-Brotons, Michelle Chen, Ryan J. Ice, Edith Vaquero, Damon Jian, Pierre-Yves Desprez, Mehdi Nosrati, Leah Galvez, Lewis Leng, Lawrence Dickinson, Mohammed Kashani-Sabet, Sean David McAllister, Liliana Soroceanu
Publikováno v:
Cells, Vol 12, Iss 4, p 547 (2023)
Glioblastoma’s (GBM) aggressive growth is driven by redundant activation of a myriad of signaling pathways and genomic alterations in tyrosine kinase receptors, such as epidermal growth factor receptor (EGFR), which is altered in over 50% of cases.
Externí odkaz:
https://doaj.org/article/1d5f3985b148428794259e6a9e3960e3
Autor:
Chandani Limbad, Tal Ronnen Oron, Fatouma Alimirah, Albert R Davalos, Tara E Tracy, Li Gan, Pierre-Yves Desprez, Judith Campisi
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227887 (2020)
Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of patients with Alzheimer's and related dementias and cancer patients after chemo- or radio-therapies. A recently emerged driver of these and other age-related p
Externí odkaz:
https://doaj.org/article/6d1b037837964e13b4012a4b77ba6628
Autor:
Edie Zusman, Maxim Sidorov, Alexandria Ayala, Jimmin Chang, Eric Singer, Michelle Chen, Pierre-Yves Desprez, Sean McAllister, Nathan Salomonis, Kashish Chetal, Gautam Prasad, Tyler Kang, Joseph Mark, Lawrence Dickinson, Liliana Soroceanu
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. Designing effective individualized therapies for GBM requires quality fresh tissue specimens, and a comprehensive molecular profile of this highly heterogenous neoplasm. Novel n
Externí odkaz:
https://doaj.org/article/7e201f5b71f8422f8fa6a3b058ad7da7
Autor:
Christopher D. Wiley, Su Liu, Chandani Limbad, Anna M. Zawadzka, Jennifer Beck, Marco Demaria, Robert Artwood, Fatouma Alimirah, Jose-Alberto Lopez-Dominguez, Chisaka Kuehnemann, Steven R. Danielson, Natan Basisty, Herbert G. Kasler, Tal Ronnen Oron, Pierre-Yves Desprez, Sean D. Mooney, Bradford W. Gibson, Birgit Schilling, Judith Campisi, Pankaj Kapahi
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3329-3337.e5 (2019)
Summary: Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that participates in several age-related diseases. Using stable isotope labeling with amino acids
Externí odkaz:
https://doaj.org/article/18d57d9f49ba45cebd45a0fa32ce2405
Autor:
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Yu Sun, Denise P Muñoz, Joshua Goldstein, Peter S Nelson, Pierre-Yves Desprez, Judith Campisi
Publikováno v:
PLoS Biology, Vol 6, Iss 12, Pp 2853-2868 (2008)
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to provide a quantitative assessment of factors secre
Externí odkaz:
https://doaj.org/article/45144fb904334b6d83ac21f7112cd481
Autor:
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Ana Krtolica, Christian M Beauséjour, Simona Parrinello, J Graeme Hodgson, Koei Chin, Pierre-Yves Desprez, Judith Campisi
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9188 (2010)
Cellular senescence irreversibly arrests cell proliferation in response to oncogenic stimuli. Human cells develop a senescence-associated secretory phenotype (SASP), which increases the secretion of cytokines and other factors that alter the behavior
Externí odkaz:
https://doaj.org/article/b62d72a8147f4f1b91c4a605676da332