Výsledky vyhledávání - "Pierre-Marie Sinet"

Quantification of Mn-SOD mRNAs by using a competitive reverse-transcription polymerase chain reaction

Autor: C. Ribière, Pierre-Marie Sinet, B. Aral, Irène Ceballos-Picot, D. Santiard-Baron, R. Nordmann

Publikováno v: Redox report : communications in free radical research. 1(3)

The manganese superoxide dismutase plays an important role in the cellular response to oxidative stress and appears to be highly regulated by many factors. The study of this gene's expression is difficult to achieve due to multiple rat Mn-SOD transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01625998d1893edf5e1a4b2893581461
https://pubmed.ncbi.nlm.nih.gov/27414274

Zobrazit plný text záznamu

Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation

Autor: Coline Haxaire, Gérard Barbanel, Patrick Dutar, Fabrice R. Turpin, Brigitte Potier, Jean-Pierre Mothet, Myriam Kervern, Pierre-Marie Sinet, Jean-Marie Billard

Publikováno v: Aging Cell. 11:336-344

Oxidative stress (OS) resulting from an imbalance between antioxidant defenses and the intracellular accumulation of reactive oxygen species (ROS) contributes to age-related memory deficits. While impaired synaptic plasticity in neuronal networks is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfceb634abae3184a7f536e8e4804066
https://doi.org/10.1111/j.1474-9726.2012.00792.x

Zobrazit plný text záznamu

Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

Autor: Pierre-Marie Sinet, Melanie Kollen, A. Jouvenceau, Isabelle Denis, Gaëlle Champeil-Potokar, Jean-Marie Billard, Brigitte Potier, Patrick Dutar, Barbara Grintal, Sylvain Rivière

Publikováno v: Aging Cell. 9:722-735

This study aims to determine whether the regulation of extracellular glutamate is altered during aging and its possible consequences on synaptic transmission and plasticity. A decrease in the expression of the glial glutamate transporters GLAST and G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e763f5013aea7ef6aa50010ed5f60d8
https://doi.org/10.1111/j.1474-9726.2010.00593.x

Zobrazit plný text záznamu

The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome

Autor: Léon Personnaz, Laurence Ettwiller, Robert Lyle, Luce Dauphinot, Isabelle Rivals, Jean Rossier, K. Toyama, M. Tran Dang, Pierre-Marie Sinet, Charles J. Epstein, Randal X. Moldrich, G. Golfier, M.-C. Potier, Stylianos E. Antonarakis

Publikováno v: Human Molecular Genetics, Vol. 14, No 3 (2005) pp. 373-384
Europe PubMed Central

The central nervous system of persons with Down syndrome presents cytoarchitectural abnormalities that likely result from gene-dosage effects affecting the expression of key developmental genes. To test this hypothesis, we have investigated the trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8fe46bf4b88bf1aa4c607c1da201d2
https://doi.org/10.1093/hmg/ddi033

Zobrazit plný text záznamu

Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study

Autor: Charles J. Epstein, François Vialard, Pierre-Marie Sinet, Stéphane Vernoux, Kiyoko Toyama, Elaine J. Carlson, Zohra Rahmani

Publikováno v: Developmental Brain Research. 121:73-78

Trisomy 21 (Down syndrome) is the most common chromosomal abnormality associated with mental retardation in humans. Sim2, a human homologue of Drosophila sim gene, which acts as a master regulator of the early development of the fly central nervous s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c1821c762b2e3e6776d74207ae5b5e
https://doi.org/10.1016/s0165-3806(00)00026-2

Zobrazit plný text záznamu

Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development

Autor: Pierre-Marie Sinet, Svetlana Gassanova, Carmela Lopes, Mohammed Rachidi, Michel Vekemans, T Attié, Jean-Maurice Delabar, Anne-Lise Delezoide

Publikováno v: Mechanisms of Development. 93(1-2):189-193

The TPRD gene (tetratricopeptide (TPR) containing Down syndrome gene) is one of the candidate genes in the Down syndrome chromosomal region-1. Duplication of this gene may be the cause of major phenotypic features of Down syndrome. Here we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942a0347accd9632574b9a535d0557ac

Zobrazit plný text záznamu

Characterization of a Novel Gene, C21orf6, Mapping to a Critical Region of Chromosome 21q22.1 Involved in the Monosomy 21 Phenotype and of Its Murine Ortholog, orf5

Autor: R. Orti, André Rosenthal, Stefan Taudien, Pierre-Marie Sinet, Marie-Laure Yaspo, Jean-Maurice Delabar, Carmela Lopes, François Vialard, Mohammed Rachidi, Kiyoko Toyama

Publikováno v: Genomics. 64:203-210

Phenotypic and molecular analyses of patients with partial chromosome 21 monosomy enabled us to define a region, spanning 2.4 Mb between D21S190 and D21S226, associated with arthrogryposis, mental retardation, hypertonia, and several facial anomalies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d25cdcaa113feae0e84bad040d3b12
https://doi.org/10.1006/geno.1999.6109

Zobrazit plný text záznamu

Overproduction of Cu/Zn-Superoxide Dismutase or Bcl-2 Prevents the Brain Mitochondrial Respiratory Dysfunction Induced by Glutathione Depletion

Autor: Irène Ceballos-Picot, Mansouria Mérad-Saı̈doune, Pierre-Marie Sinet, Brigitte Sola, Annie Nicole, Eric Boitier, Jean-Claude Martinou, Cécile Marsac

Publikováno v: Experimental Neurology
Experimental Neurology, Elsevier, 1999, 158 (2), pp.428-436. ⟨10.1006/exnr.1999.7108⟩

International audience; Recent work has focused attention on the role of oxidative stress in various acute and chronic neurodegenerative diseases. Low concentrations of the powerful antioxidant glutathione (GSH) and impaired brain energy metabolism,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3ecc3c8e08c55953877569a0bcf884
https://doi.org/10.1006/exnr.1999.7108

Zobrazit plný text záznamu

Identification of β-Amyloid-Responsive Genes by RNA Differential Display: Early Induction of a DNA Damage-Inducible Gene, gadd45

Autor: Yves Christen, Annie Nicole, Irène Ceballos-Picot, Dominique Santiard-Baron, Pierre-Marie Sinet, Philippe Gosset

Publikováno v: Experimental Neurology. 158:206-213

Alzheimer's disease is a neurodegenerative disorder characterized by the extracellular deposition in the brain of amyloid beta-peptide (A beta), presumed to play a pathogenic role. However, the precise molecular mechanisms of its neurotoxicity are no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc20e763ee24f5ef40d358963a6c607
https://doi.org/10.1006/exnr.1999.7076

Zobrazit plný text záznamu

Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1

Autor: Pierre-Marie Sinet, Svetlana Gassanova, Carmela Lopes, Mohammed Rachidi, Jean-Maurice Delabar

Publikováno v: Mechanisms of Development. 84:189-193

The gene tprd, which contains three tetratricopeptide domains, has been recently localized in the Down syndrome (DS) chromosomal region 1. We have cloned a cDNA encoding part of the murine ortholog of tprd and used it to characterize the expression p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133f2691f9dde88caed15f986c4d7318
https://doi.org/10.1016/s0925-4773(99)00076-3

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání