Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Pierre-Marie Andrault"'
1
Elastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification
Autor: Preety Panwar, Neil C. W. Mackenzie, Pierre-Marie Andrault, Dieter Brömme
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Elastin plays an important role in maintaining blood vessel integrity. Proteolytic degradation of elastin in the vascular system promotes the development of atherosclerosis, including blood vessel calcification. Cysteine cathepsins have been implicat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5ee6e32bfbfd0c424551d44035d336
http://link.springer.com/article/10.1038/s41598-019-45918-1
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2
The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V
Autor: Pierre-Marie Andrault, Sergey A. Samsonov, Sophie Denamur, Krzysztof K. Bojarski, Fuming Zhang, Ahlame Saidi, Fabien Lecaille, Dieter Brömme, M. Tardieu, François Labarthe, Thibault Chazeirat, Robert J. Linhardt, Gilles Lalmanach, Damien Sizaret
Publikováno v: Carbohydrate Polymers
Carbohydrate Polymers, 2021, 253, pp.117261-. ⟨10.1016/j.carbpol.2020.117261⟩
Carbohydrate Polymers, Elsevier, 2021, 253, pp.117261-. ⟨10.1016/j.carbpol.2020.117261⟩
International audience; Mucopolysaccharidosis (MPS) are rare inherited diseases characterized by accumulation of lysosomal glycosaminoglycans, including heparan sulfate (HS). Patients exhibit progressive multi-visceral dysfunction and shortened lifes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1bff7eccfa616a990c6345ac9050d4
https://hal.science/hal-03493189
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3
Oxidation of cathepsin S by major chemicals of cigarette smoke
Autor: Lydie Nadal-Desbarats, Pierre-Marie Andrault, Gilles Lalmanach, Ahlame Saidi, Paul Bigot, Mylène Wartenberg, Fabien Lecaille
Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2020, 150, pp.53-65. ⟨10.1016/j.freeradbiomed.2020.02.013⟩
International audience; Lung cysteine cathepsin S (CatS) that is a potent elastase plays a deleterious role in alveolar remodeling during smoke-induced emphysema. Despite the presence of a reactive nucleophilic cysteine (Cys25) within its active site
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ee722b0e527abc3c86ea7d05e86889
https://hal.archives-ouvertes.fr/hal-03677268
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4
Label-Free Mass Quantitation of Individual Cathepsin K Enzymes using Interferrometric Scattering Microscopy
Autor: Edward R. Grant, Luke Melo, Dieter Brömme, Matthew Kowal, Pierre-Marie Andrault
Publikováno v: Imaging and Applied Optics Congress.
Interferrometric scattering microscopy is used to mass quantify individual Cathepsin K enzymes in solution. Treatments for osteoporosis are assessed by monitoring the oligomerization of Cathepsin K.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3be4c233355f41ea04f7e68a2f4cecf9
https://doi.org/10.1364/3d.2020.jth2a.30
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5
Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation
Autor: Christian E.H. Schmelzer, Andrea Heinz, Preety Panwar, David J. Granville, Pierre-Marie Andrault, Wolfgang Hoehenwarter, Tobias Hedtke, Dieter Brömme
Background Skin ageing is associated with structure-functional changes in the extracellular matrix, which is in part caused by proteolytic degradation. Since cysteine cathepsins are major matrix protein-degrading proteases, we investigated the age-de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8651b55bfbb83969de1b987e5c04124d
https://publica.fraunhofer.de/handle/publica/262432
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6
Characterization of cathepsin S exosites that govern its elastolytic activity
Autor: Pierre-Marie Andrault, Preety Panwar, Dieter Brömme
Publikováno v: The Biochemical journal. 477(1)
We have previously determined that the elastolytic activities of cathepsins (Cat) K and V require two exosites sharing the same structural localization on both enzymes. The structural features involved in the elastolytic activity of CatS have not yet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff62aaf8563825e7cd0f0e6567b6770
https://pubmed.ncbi.nlm.nih.gov/31860022
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7
Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD
Autor: Thomas Baranek, Agnès Petit-Courty, Andrea C. Schamberger, Fabien Lecaille, Ahlame Saidi, Pierre-Marie Andrault, Oliver Eickelberg, Thibault Chazeirat, Damien Sizaret, Mylène Wartenberg, Serge Guyétant, Elisabeth Hennen, Gilles Lalmanach, Justine Renault, Yves Courty, Claudia A. Staab-Weijnitz
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2019, 317 (5), pp.L625-L638. ⟨10.1152/ajplung.00061.2019⟩
Am. J. Physiol. Lung Cell Mol. Physiol. 317, L625-L638 (2019)
International audience; Cigarette smoking has marked effects on lung tissue, including induction of oxidative stress, inflammatory cell recruitment, and a protease/antiprotease imbalance. These effects contribute to tissue remodeling and destruction
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ccbff970691c72a8be55cbc9f06d21
https://hal.archives-ouvertes.fr/hal-03604585
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8
Cigarette smoke induces overexpression of cathepsin S in active smokers with and without COPD
Autor: Gilles Lalmanach, Andrea C. Schamberger, Thibault Chazeirat, Serge Guyétant, Damien Sizaret, Oliver Eickelberg, Justine Renault, Mylène Wartenberg, Yves Courty, Pierre-Marie Andrault, Ahlame Saidi, Agnès Petit, Fabien Lecaille
Publikováno v: Airway Cell Biology and Immunopathology.
Background: Cigarette smoking induces molecular changes within the lung, including oxidative stress, inflammatory cell recruitment and a protease/anti-protease imbalance, which contributes in part to emphysema, airway remodeling and airway obstructio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f7f43333076b40d33f58d6d5cc8809a
https://doi.org/10.1183/13993003.congress-2018.pa4272
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9
Deciphering molecular mechanisms of cathepsin S resistance to major chemical oxidants of cigarette smoke
Autor: Fabien Lecaille, Gilles Lalmanach, Lydie Nadal-Desbarats, Mylène Wartenberg, Ahlame Saidi, Pierre-Marie Andrault
Publikováno v: Mechanisms of Lung Injury and Repair.
Background: Cathepsin S (CatS) is a potent elastase playing a key role in ECM remodeling during COPD. A crucial risk factor for COPD is the exposure to cigarette smoke (CS), a major source of oxidants that contribute to lung inflammation. Aims and ob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d1c66888df529cbb52245558f4187ef
https://doi.org/10.1183/13993003.congress-2018.pa4312
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10
Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib
Autor: Natasha Kruglyak, Simon Law, Nham T. Nguyen, Pierre-Marie Andrault, Adeleke Aguda, Gary D. Brayer, Dieter Brömme
Publikováno v: The Biochemical journal. 474(5)
Cathepsin K (CatK) is the predominant mammalian bone-degrading protease and thus an ideal target for antiosteoporotic drug development. Rodent models of osteoporosis are preferred due to their close reflection of the human disease and their ease of h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528f8124f48a3617ed134c2be566f2bf
https://pubmed.ncbi.nlm.nih.gov/28049758
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