Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Pierre-M. Bélanger"'
Autor:
Sylvie Pilote, Jean G. Dumesnil, Bernd Meibohm, Ashish Sharma, Philippe Pibarot, Bettina A. Hamelin, Pierre M. Bélanger, Marie Arsenault
Publikováno v:
The Journal of Clinical Pharmacology. 50:214-225
The objective of this study was to determine if sex influences the pharmacokinetics and hemodynamics of the CYP2D6 substrate metoprolol and its interaction with diphenhydramine (CYP2D6 inhibitor) in healthy young participants with high (extensive met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ba27db64327a43baa91d51c9b9fd1f
https://doi.org/10.1177/0091270009340417
https://doi.org/10.1177/0091270009340417
Autor:
Gilles O'Hara, Etienne Lessard, Line Labbé, Bettina A. Hamelin, Pierre M. Bélanger, Jacques Turgeon
Publikováno v:
Pharmacogenetics and Genomics. 9:683-696
Occurrence of a lupus-like syndrome in a significant number of patients treated with procainamide has limited the clinical use of this antiarrhythmic drug. In-vitro studies conducted in our laboratory have demonstrated that CYP2D6 is the major cytoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47564c1982d93d84caf078abb1784af9
https://doi.org/10.1097/01213011-199912000-00003
https://doi.org/10.1097/01213011-199912000-00003
Publikováno v:
Pharmaceutical Research. 12:455-458
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fded8053f094ea22c5b6cfded93c277
https://doi.org/10.1023/a:1016277223852
https://doi.org/10.1023/a:1016277223852
Autor:
Pierre M. Bélanger, Gaston Labrecque
Publikováno v:
Pharmacology & Therapeutics. 52:95-107
Studies carried out in the last 20 years indicated that biological rhythms can be detected in the pharmacokinetics of most classes of drugs. These time-dependent variations could be due to parallel changes in the physiological functions and variables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cd8c1ff0ac32f09870e0e040146fc0
https://doi.org/10.1016/0163-7258(91)90088-4
https://doi.org/10.1016/0163-7258(91)90088-4
Autor:
Jacques Turgeon, Andrew C. G. Uprichard, Dean W.G. Harron, Odette Grech-Bélanger, Pierre M. Bélanger
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:630-635
Resolution of mexiletine enantiomers from the racemic mixture has been achieved by fractional crystallization through the formation of diastereoisomeric p-toluoyl tartrate salts. Following three crystallization steps in methanol, R-(–)- and S-(+)-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63caf3dc855248b78c3b41c5d1586439
https://doi.org/10.1111/j.2042-7158.1991.tb03552.x
https://doi.org/10.1111/j.2042-7158.1991.tb03552.x
Autor:
Serge St-Hilaire, Pierre M. Bélanger
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:400-405
The in vitro metabolism of tolbutamide to the hydroxymethyl derivative was studied using hepatic microsomal homogenates. The hydroxymethyl metabolite was quantitated by HPLC. The hepatic microsomal hydroxylase was completely inhibited by carbon monox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604b69327339d054f06f722130930e06
https://doi.org/10.1139/y91-061
https://doi.org/10.1139/y91-061
Autor:
Marie Arsenault, Bernd Meibohm, Sylvie Pilote, Bettina A. Hamelin, Ashish Sharma, Pierre M. Bélanger, Philippe Pibarot, Jean G. Dumesnil
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 313(3)
Premenopausal women may be most vulnerable to acute coronary syndromes at a point in their menstrual cycle when their plasma estrogen levels are the lowest during and immediately after menstruation. Metoprolol is a first-line drug in the management o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac1e4b03d2d141778ffcb7b58ae0f60
https://pubmed.ncbi.nlm.nih.gov/15718288
https://pubmed.ncbi.nlm.nih.gov/15718288
A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study
Publikováno v:
British journal of clinical pharmacology. 58(3)
Aims To assess the feasibility of administering at the same time low doses of five probe drugs, metoprolol (25 mg), chlorzoxazone (250 mg), tolbutamide (250 mg), dapsone (100 mg) and caffeine (100 mg) to determine simultaneously the activities of CYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648b8587e6f333c918d13fa04b1e022d
https://pubmed.ncbi.nlm.nih.gov/15327588
https://pubmed.ncbi.nlm.nih.gov/15327588
Publikováno v:
Chronobiology international. 7(5-6)
In this in vivo study, the time-dependent effect of oral sodium warfarin was studied in male rats synchronized under a 12-hr light-dark cycle (light 0600-1800). Groups of 5 animals received an oral dose of 500 micrograms/kg of warfarin or saline at 0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016ed1fc3b090b288534654152a401a8
https://pubmed.ncbi.nlm.nih.gov/2097073
https://pubmed.ncbi.nlm.nih.gov/2097073