Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Pierre-Luc Germain"'
Autor:
Mark D Robinson, Peiying Cai, Martin Emons, Reto Gerber, Pierre-Luc Germain, Samuel Gunz, Siyuan Luo, Giulia Moro, Emanuel Sonder, Anthony Sonrel, Jiayi Wang, David Wissel, Izaskun Mallona
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012174 (2024)
Computational biologists are frequently engaged in collaborative data analysis with wet lab researchers. These interdisciplinary projects, as necessary as they are to the scientific endeavor, can be surprisingly challenging due to cultural difference
Externí odkaz:
https://doaj.org/article/3ef38d0c3f5942499a2dc36843d17ca8
Autor:
Mahshid Gazorpak, Karina M. Hugentobler, Dominique Paul, Pierre-Luc Germain, Miriam Kretschmer, Iryna Ivanova, Selina Frei, Kei Mathis, Remo Rudolf, Sergio Mompart Barrenechea, Vincent Fischer, Xiaohan Xue, Aleksandra L. Ptaszek, Julian Holzinger, Mattia Privitera, Andreas Hierlemann, Onno C. Meijer, Robert Konrat, Erick M. Carreira, Johannes Bohacek, Katharina Gapp
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist lacks selectivity and induces unwanted side effects. To co
Externí odkaz:
https://doaj.org/article/a28a8f76999f4d2694653264846e8de2
Autor:
Vincent Fischer, Miriam Kretschmer, Pierre-Luc Germain, Jasmine Kaur, Sergio Mompart-Barrenechea, Pawel Pelczar, David Schürmann, Primo Schär, Katharina Gapp
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Dexamethasone is a stress hormone receptor agonist used widely in clinics. We and others previously showed that paternal administration of dexamethasone in mice affects the phenotype of their offspring. The substrate of intergenerational tra
Externí odkaz:
https://doaj.org/article/5198a92cd6a1478f8414a17dd3b16284
Autor:
Mattia Privitera, Lukas M von Ziegler, Amalia Floriou-Servou, Sian N Duss, Runzhong Zhang, Rebecca Waag, Sebastian Leimbacher, Oliver Sturman, Fabienne K Roessler, Annelies Heylen, Yannick Vermeiren, Debby Van Dam, Peter P De Deyn, Pierre-Luc Germain, Johannes Bohacek
Publikováno v:
eLife, Vol 12 (2024)
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here, we combine RNA sequencing with selective
Externí odkaz:
https://doaj.org/article/e31eb3ec28a24c24ac3e22f507e84dfa
Autor:
Anthony Sonrel, Almut Luetge, Charlotte Soneson, Izaskun Mallona, Pierre-Luc Germain, Sergey Knyazev, Jeroen Gilis, Reto Gerber, Ruth Seurinck, Dominique Paul, Emanuel Sonder, Helena L. Crowell, Imran Fanaswala, Ahmad Al-Ajami, Elyas Heidari, Stephan Schmeing, Stefan Milosavljevic, Yvan Saeys, Serghei Mangul, Mark D. Robinson
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Computational methods represent the lifeblood of modern molecular biology. Benchmarking is important for all methods, but with a focus here on computational methods, benchmarking is critical to dissect important steps of analysis pipelines,
Externí odkaz:
https://doaj.org/article/21cd2e92fd404c0081d6e6fad0fc21dd
Autor:
Lukas M. von Ziegler, Amalia Floriou-Servou, Rebecca Waag, Rebecca R. Das Gupta, Oliver Sturman, Katharina Gapp, Christina A. Maat, Tobias Kockmann, Han-Yu Lin, Sian N. Duss, Mattia Privitera, Laura Hinte, Ferdinand von Meyenn, Hanns U. Zeilhofer, Pierre-Luc Germain, Johannes Bohacek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Acute stress can help individuals to respond to challenging events, although chronic stress leads to maladaptive changes. Here, the authors present a multi omic analysis profiling acute stress-induced changes in the mouse hippocampus, providing a res
Externí odkaz:
https://doaj.org/article/859e65c14b6146b5b795319376098f0e
Autor:
Ruizhu Huang, Charlotte Soneson, Pierre-Luc Germain, Thomas S.B. Schmidt, Christian Von Mering, Mark D. Robinson
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract treeclimbR is for analyzing hierarchical trees of entities, such as phylogenies or cell types, at different resolutions. It proposes multiple candidates that capture the latent signal and pinpoints branches or leaves that contain features of
Externí odkaz:
https://doaj.org/article/b1d8cc0b3f064bf1a238e2055b34cbd8
Publikováno v:
F1000Research, Vol 10 (2022)
Doublets are prevalent in single-cell sequencing data and can lead to artifactual findings. A number of strategies have therefore been proposed to detect them. Building on the strengths of existing approaches, we developed scDblFinder, a fast, flexib
Externí odkaz:
https://doaj.org/article/01947a7047644aa491defd5323c493be
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Despite the importance of alternative poly-adenylation and 3′ UTR length for a variety of biological phenomena, there are limited means of detecting UTR changes from standard transcriptomic data. Results We present the diffUTR B
Externí odkaz:
https://doaj.org/article/c863eab337b84523b3d205d770250914
Autor:
Reetu Daswani, Carlotta Gilardi, Michael Soutschek, Prakruti Nanda, Kerstin Weiss, Silvia Bicker, Roberto Fiore, Christoph Dieterich, Pierre-Luc Germain, Jochen Winterer, Gerhard Schratt
Publikováno v:
eLife, Vol 11 (2022)
The proper development and function of neuronal circuits rely on a tightly regulated balance between excitatory and inhibitory (E/I) synaptic transmission, and disrupting this balance can cause neurodevelopmental disorders, for example, schizophrenia
Externí odkaz:
https://doaj.org/article/a5a070b8ebc54d738e70853f52978666