Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Pierre-Louis Ruffault"'
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Akademický článek
Mafa-dependent GABAergic activity promotes mouse neonatal apneas
Autor: Laure Lecoin, Bowen Dempsey, Alexandra Garancher, Steeve Bourane, Pierre-Louis Ruffault, Marie-Pierre Morin-Surun, Nathalie Rocques, Martyn Goulding, Alain Eychène, Celio Pouponnot, Gilles Fortin, Jean Champagnat
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Apneas are associated with many pathological conditions. Here, the authors show in a mouse model that stabilization of the transcription factor Mafa in brainstem GABAergic neurons may contribute to apnea, by decreasing motor drive to muscles controll
Externí odkaz: https://doaj.org/article/4e5a7c519af7455ca59539ab8c61aa59
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2
Akademický článek
Cell fixation and preservation for droplet-based single-cell transcriptomics
Autor: Jonathan Alles, Nikos Karaiskos, Samantha D. Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks, Nikolaus Rajewsky
Publikováno v: BMC Biology, Vol 15, Iss 1, Pp 1-14 (2017)
Abstract Background Recent developments in droplet-based microfluidics allow the transcriptional profiling of thousands of individual cells in a quantitative, highly parallel and cost-effective way. A critical, often limiting step is the preparation
Externí odkaz: https://doaj.org/article/99124dcd8c55450daeac011f7ea790a9
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3
Akademický článek
The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2
Autor: Pierre-Louis Ruffault, Fabien D'Autréaux, John A Hayes, Marc Nomaksteinsky, Sandra Autran, Tomoyuki Fujiyama, Mikio Hoshino, Martin Hägglund, Ole Kiehn, Jean-François Brunet, Gilles Fortin, Christo Goridis
Publikováno v: eLife, Vol 4 (2015)
Maintaining constant CO2 and H+ concentrations in the arterial blood is critical for life. The principal mechanism through which this is achieved in mammals is the respiratory chemoreflex whose circuitry is still elusive. A candidate element of this
Externí odkaz: https://doaj.org/article/be6e0678773e4ee880644e9459d90648
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5
Prox2+ and Runx3+ neurons regulate esophageal motility
Autor: Elijah D. Lowenstein, Pierre-Louis Ruffault, Aristotelis Misios, Kate L. Osman, Huimin Li, Rebecca Thompson, Kun Song, Stephan Dietrich, Xun Li, Nikita Vladimirov, Jean-François Brunet, Andrew Woehler, Niccolò Zampieri, Ralf Kühn, Shiqi Jia, Gary R. Lewin, Nikolaus Rajewsky, Teresa E. Lever, Carmen Birchmeier
SummarySensory neurons of the vagus nerve monitor distention and stretch in the gastrointestinal tract. Major efforts are underway to assign physiological functions to the many distinct subtypes of vagal sensory neurons. Here, we used genetically gui
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e6cf2d0215bda175f0e45c8bbd1d98b
https://doi.org/10.1101/2022.07.07.499111
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6
Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse
Autor: Charlotte Chaimowicz, Gilles Fortin, Andrew Woehler, Carmen Birchmeier, Alistair N. Garratt, Cyril Cheret, Pierre-Louis Ruffault, Niccolò Zampieri
Publikováno v: Developments in Biologicals
Developments in Biologicals, Karger, 2019, ⟨10.1242/dev.174045⟩
Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2019, 146 (17), pp.dev174045. ⟨10.1242/dev.174045⟩
Feeding and breathing are essential motor functions and rely on the activity of hypoglossal and phrenic motor neurons that innervate the tongue and diaphragm, respectively. Little is known about the genetic programs that control the development of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ccee61d25759a357bb03cb8f54bf7a
https://hal.archives-ouvertes.fr/hal-02394585/document
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7
Self-Organizing 3D Human Trunk Neuromuscular Organoids
Autor: Iris Hube, Elisabeta Gazzerro, Ramon Vidal, Carmen Birchmeier, Pierre-Louis Ruffault, Mina Gouti, Séverine Kunz, Jorge-Miguel Faustino Martins, Sascha Sauer, Cornelius Fischer, Alessia Urzi, Simone Spuler, Loreen Kabuss
Publikováno v: Cell Stem Cell. 27:498
Neuromuscular networks assemble during early human embryonic development and are essential for the control of body movement. Previous neuromuscular junction modeling efforts using human pluripotent stem cells (hPSCs) generated either spinal cord neur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9b7e9439ca1f3327f936dd614f11cb
https://doi.org/10.1016/j.stem.2020.08.011
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8
Mutation in
Autor: Luis Rodrigo, Hernandez-Miranda, Daniel M, Ibrahim, Pierre-Louis, Ruffault, Madeleine, Larrosa, Kira, Balueva, Thomas, Müller, Willemien de, Weerd, Irene, Stolte-Dijkstra, Robert M W, Hostra, Jean-François, Brunet, Gilles, Fortin, Stefan, Mundlos, Carmen, Birchmeier
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance Maintaining low CO2 levels in our bodies is critical for life and depends on neurons that generate the respiratory rhythm and monitor tissue gas levels. Inadequate response to increasing levels of CO2 is common in congenital hypoventilat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c76411ef372831b1a6c712204622864
https://pubmed.ncbi.nlm.nih.gov/30487221
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9
Computer-aided neurophysiology and imaging with open-source PhysImage
Autor: Valentina Emiliani, Gilles Fortin, Pierre-Louis Ruffault, John A. Hayes, Eirini Papagiakoumou
Publikováno v: Journal of Neurophysiology
Journal of Neurophysiology, American Physiological Society, 2018, 120, pp.23-36. ⟨10.1152/jn.00048.2017⟩
Improved integration between imaging and electrophysiological data has become increasingly critical for rapid interpretation and intervention as approaches have advanced in recent years. Here, we present PhysImage, a fork of the popular public-domain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75626db0599bc896de11e96a2366081
https://hal.archives-ouvertes.fr/hal-02394498/document
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10
Genetic identification of a hindbrain nucleus essential for innate vocalization
Autor: Julien Bouvier, Carmen Birchmeier, Gilles Fortin, Marie-Pierre Morin-Surun, Jean Champagnat, Luis R. Hernandez-Miranda, Justyna Cholewa-Waclaw, Pierre-Louis Ruffault, Niccolò Zampieri, Andrew J. Murray, Jean-François Brunet, Elodie Ey
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (30), pp.8095-8100. ⟨10.1073/pnas.1702893114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (30), pp.8095-8100. ⟨10.1073/pnas.1702893114⟩
International audience; Vocalization in young mice is an innate response to isolation or mechanical stimulation. Neuronal circuits that control vocalization and breathing overlap and rely on motor neurons that innervate laryngeal and expiratory muscl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9eead34405859e1cde91cb73f943c0
https://pubmed.ncbi.nlm.nih.gov/28698373
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