Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pierre-Emmanuel Morin"'
Autor:
Zia Mohaddes, Samir Das, Rida Abou-Haidar, Mouna Safi-Harab, David Blader, Jessica Callegaro, Charlie Henri-Bellemare, Jingla-Fri Tunteng, Leigh Evans, Tara Campbell, Derek Lo, Pierre-Emmanuel Morin, Victor Whitehead, Howard Chertkow, Alan C. Evans
Publikováno v:
Frontiers in Neuroinformatics, Vol 12 (2018)
The Canadian Institutes for Health Research (CIHR) launched the “International Collaborative Research Strategy for Alzheimer's Disease” as a signature initiative, focusing on Alzheimer's Disease (AD) and related neurodegenerative disorders (NDDs)
Externí odkaz:
https://doaj.org/article/e9f72f0a88e8470a9089aeb0b2d3a489
Publikováno v:
Journal of Separation Science. 30:1191-1199
The use of sub-2-microm particle columns for fast high throughput metabolite ID applications was investigated. Three LC-MS methods based on different sub-2-microm particle size columns using the same analytical 3 min gradient were developed (Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e868f2c885e8b662519a315b814de9c0
https://doi.org/10.1002/jssc.200600538
https://doi.org/10.1002/jssc.200600538
Publikováno v:
Xenobiotica. 33:841-854
1. The aim was to identify the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of morphine in vitro. 2. In human liver microsomes, normorphine formation followed Michaelis-Menten kinetics with mean Km and Vmax of 12.4 +/- 2.2 mM and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4222c8e5057da8135928b75aac812250
https://doi.org/10.1080/0049825031000121608
https://doi.org/10.1080/0049825031000121608
Autor:
Pierre-Emmanuel Morin, Scott W. Martin, Robin Smith, Ralf Schmidt, Malken Bayrakdarian, Eva M. Lenz, Daniel J. Weston
Publikováno v:
Chemical research in toxicology. 27(6)
Successful early attrition of potential problematic compounds is of great importance in the pharmaceutical industry. The lead compound in a recent project targeting neuropathic pain was susceptible to metabolic bioactivation, which produced reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7e161428d73878039a3ebeea1f2bc4
https://pubmed.ncbi.nlm.nih.gov/24855970
https://pubmed.ncbi.nlm.nih.gov/24855970
Autor:
Marie Roumi, Dominic Salois, Christopher Walpole, Lynda Adam, William Brown, Mylene Gosselin, Pierre-Emmanuel Morin, Andrew Griffin, Martin Coupal
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(21)
We have investigated phenol replacements in a series of diaryl amino piperidine delta opioid agonists. From this study we have demonstrated that the hydroxy functional group can be replaced with a primary amide group, giving enhanced activity at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4509e8ae81550e436ca52392014d70e4
https://pubmed.ncbi.nlm.nih.gov/19800790
https://pubmed.ncbi.nlm.nih.gov/19800790
Autor:
Wei Zhongyong, Fei Zhou, Stephane St-Onge, Daniel Delorme, Pierre-Emmanuel Morin, Ralf Schmidt, Christopher Walpole, Maryse Labarre, Julie Ducharme, Benjamin Pelcman, Denis Projean, Kemal Payza, Shi Yi Yue, Helene Gagnon, Hua Yang, William Brown, Lars Gawell, Augustus Kamassah, Edward Roberts, Edward Zhou, Niklas Plobeck, Peter Schwarz
Publikováno v:
Journal of medicinal chemistry. 43(21)
Nonpeptide delta opioid agonists are analgesics with a potentially improved side-effect and abuse liability profile, compared to classical opioids. Andrews analysis of the NIH nonpeptide lead SNC-80 suggested the removal of substituents not predicted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9712a1e21e6971a34a29440bf30ca9be
https://pubmed.ncbi.nlm.nih.gov/11052793
https://pubmed.ncbi.nlm.nih.gov/11052793
Autor:
William Brown, Claude Godbout, Denis Projean, Bryan K. Takasaki, Ralf Schmidt, Joanne Butterworth, Wei Zhongyong, Helene Gagnon, Lars Gawell, Pierre-Emmanuel Morin, Chris Walpole, Daniel Delorme, Hua Yang, Julie Ducharme, Edward Roberts, Paul Jones, Maryse Labarre, Shi-Yi Yue, Andrea Jakob, Augustus Kamassah, Kemal Payza, Niklas Plobeck, Fei Zhou, Stephane St-Onge
Publikováno v:
Journal of medicinal chemistry. 43(21)
The design, synthesis, and pharmacological evaluation of a novel class of delta opioid receptor agonists, N, N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide (6a) and its analogues, are described. These compounds, formally derived from SNC-80 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409968a355db6a0a17b98e4365474fab
https://pubmed.ncbi.nlm.nih.gov/11052794
https://pubmed.ncbi.nlm.nih.gov/11052794