Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pierre-Alain Vitte"'
Autor:
Mario Calvitti, Claudia Volpi, Sonia-Maria Poli, Madeleine Heroux, Giada Mondanelli, Maria Laura Belladonna, Silvio Bicciato, Francesca Fallarino, Alberta Iacono, Aldo Solari, Isabelle Royer-Urios, Marco Gargaro, Cinzia Antognelli, Carmine Vacca, Céline Mordant, Mathias Cacquevel, Maria Teresa Pallotta, Paolo Puccetti, Sylvain Celanire, Ursula Grohmann, Roberta Bianchi, Ciriana Orabona, Pierre-Alain Vitte, Manfred Schneider, Elisa Albini, Laurent Galibert
Publikováno v:
Neuropharmacology
Metabotropic glutamate receptor 4 (mGluR4) possesses immune modulatory properties in vivo, such that a positive allosteric modulator (PAM) of the receptor confers protection on mice with relapsing-remitting experimental autoimmune encephalomyelitis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e92821c130279fa59a9d3c6295d4ad
http://hdl.handle.net/11391/1361142
http://hdl.handle.net/11391/1361142
Autor:
Kuniko Kohyama, Hong Ji, Thomas Rückle, Xiaoli Guo, Yoh Matsumoto, Hidenori Ichijo, Chikako Harada, Montserrat Camps, Kazuhiko Namekata, Atsushi Matsuzawa, Mathilde Muzerelle, Atsuko Kimura, Catherine Jorand-Lebrun, Takayuki Harada, Dominique Swinnen, Pierre Alain Vitte
Publikováno v:
EMBO Molecular Medicine
Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein kinase (MAPK) kinase kinase which plays important roles in stress and immune responses. Here, we show that ASK1 deficiency attenuates neuroinflammati
Autor:
Anthony Nichols, David Covini, Anna Quattropani, Jean-François Arrighi, Yves Cambet, Maurizio Maio, Thierry Martin, Olivier Schott, Bernard Françon, Laurence Novo-Perez, Don Simpson, Delphine Marin, Delphine Rivron, Cristina Donini, Agnes Bombrun, Pierre-Alain Vitte, Stefano Crosignani, Wolfgang H. B. Sauer, Isabelle Martinou, Dominique Swinnen, Valerie Eligert, Fabienne Burgat-Charvillon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1516-1519
The discovery of a novel series of S1P1 agonists is described. Starting from a micromolar HTS positive, iterative optimization gave rise to several single-digit nanomolar S1P1 agonists. The compounds were able to induce internalization of the S1P1 re
Autor:
Emile Andriambeloson, Michel Dreano, Gianni Garotta, Noelle Callizot, Pierre-Alain Vitte, Caroline Baillet
Publikováno v:
Neuropathology. 26:32-42
Neuropathy is the most severe and the least understood complication of diabetes. We investigated the potential neuroprotective effect of IL-6 therapy in an experimental model of diabetic neuropathy. A single i.v. injection of streptozotocin (STZ, 55
Autor:
Sebastien Nock, Valerie Eligert, Stefano Crosignani, Manfred Schneider, Agnes Bombrun, Adriano Luis Soares de Souza, Anna Quattropani, Delphine Marin, Susanna Carboni, Fanny Beltran, Patrick Gerber, Jerome Gonzalez, Pierre-Alain Vitte, Jerome Dorbais, Ursula Boschert, Katrin Georgi, Laurence Novo-Perez, Anthony Nichols, Mathilde Muzerelle, Wolfgang H. B. Sauer, Jennifer Hantson, Jean-François Arrighi
Publikováno v:
ChemMedChem. 10(4)
Sphingosine-1-phosphate (S1P) receptor agonists have shown promise as therapeutic agents for multiple sclerosis (MS) due to their regulatory roles within the immune, central nervous system, and cardiovascular system. Here, the design and optimization
Autor:
Steve Arkinstall, Pascale Gaillard, Denise Gretener, Cedric Szyndralewiez, Dennis Church, Christian Chabert, Vittoria Ardissone, Rocco Cirillo, Jean-Pierre Gotteland, Isabelle Jeanclaude-Etter, Montserrat Camps, Serge Halazy, Yves Cambet, Anthony Nichols, Pierre-Alain Vitte
Publikováno v:
Journal of Medicinal Chemistry. 48:4596-4607
Several lines of evidence support the hypothesis that c-Jun N-terminal kinase (JNKs) plays a critical role in a wide range of diseases including cell death (apoptosis)-related disorders (neurodegenerative diseases, brain, heart, and renal ischemia, e
Autor:
Jean-Pierre Gotteland, Sonia Carboni, Bruno Antonsson, Pascale Gaillard, Jean-Yves Gillon, Pierre-Alain Vitte
Publikováno v:
Journal of Neurochemistry. 92:1054-1060
c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is activated in response to a number of extracellular stimuli, including inflammatory cytokines, UV irradiation and ischaemia. A large body of evidence supports a
Autor:
Pierre-Alain Vitte, Sonia Carboni, Jean-Pierre Gotteland, Claudio Giachetti, Rocco Cirillo, Pascale Gaillard, Rossana Ballerio, Chiara Ferrandi
Publikováno v:
British Journal of Pharmacology. 142:953-960
1 Myocardial ischemia/reperfusion is associated with inflammation, apoptosis and necrosis. During this process, c-jun N-terminal kinase is activated in cardiac myocytes resulting in apoptosis. 2 This study investigates the effects of AS601245, a nonp
Autor:
Stanley J. Korsmeyer, Jean-Claude Martinou, Matthias Schwarz, Dennis Church, Agnes Bombrun, Bruno Antonsson, Sylvie Montessuit, Pierre-Alain Vitte, Claudio Hetz, Tatiana K. Rostovtseva, Agnes Hiver
Ischemic injuries are associated with several pathological conditions, including stroke and myocardial infarction. Several studies have indicated extensive apoptotic cell death in the infarcted area as well as in the penumbra region of the infarcted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b56093794f98060e5342e06bc1d506
https://europepmc.org/articles/PMC3531726/
https://europepmc.org/articles/PMC3531726/
Publikováno v:
Drug Development Research. 32:42-49
Medifoxamine, an antidepressant agent which has an original chemical structure, has been shown through in vitro studies, utilising radioligand binding in tissue homogenates, to bind with moderately high affinity to 5-HT1c and 5-HT2 receptor subtypes