Výsledky vyhledávání - "Pierre-Alain André"

Akademický článek

BARD1 serum autoantibodies for the detection of lung cancer.

Autor: Maxim Pilyugin, Pascaline Descloux, Pierre-Alain André, Viktoria Laszlo, Balazs Dome, Balazs Hegedus, Sylvain Sardy, Samuel Janes, Andrea Bianco, Geoffrey J Laurent, Irmgard Irminger-Finger

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182356 (2017)

Currently the screening for lung cancer for risk groups is based on Computed Tomography (CT) or low dose CT (LDCT); however, the lung cancer death rate has not decreased significantly with people undergoing LDCT. We aimed to develop a simple reliable

Externí odkaz: https://doaj.org/article/3c858d221384416286c1a87614ef638d

Zobrazit plný text záznamu

BARD1 serum autoantibodies for the detection of lung cancer

Autor: Pascaline Descloux, Irmgard Irminger-Finger, Maxim Pilyugin, Sylvain Sardy, Andrea Bianco, Sam M. Janes, Balazs Hegedus, Viktoria Laszlo, Balazs Dome, Geoffrey J. Laurent, Pierre-Alain André

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182356 (2017)
PLoS ONE

Purpose Currently the screening for lung cancer for risk groups is based on Computed Tomography (CT) or low dose CT (LDCT); however, the lung cancer death rate has not decreased significantly with people undergoing LDCT. We aimed to develop a simple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2747dbc541fcf4a268e3e6341411926c
http://europepmc.org/articles/PMC5546601?pdf=render

Zobrazit plný text záznamu

Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability

Autor: Alina Kuzniacka, Janusz Limon, Maxim Pilyugin, Julien Colas, Benjamin B. Tournier, Irmgard Irminger-Finger, Pierre-Alain André, GJ Laurent, Magdalena Ratajska

Publikováno v: Oncotarget, Vol. 8, No 6 (2017) pp. 9339-9353
Oncotarget

Previous reports have shown that expression of BARD1δ, a deletion-bearing isoform of BARD1, correlates with tumor aggressiveness and progression. We show that expression of BARD1δ induces cell cycle arrest in vitro and in vivo in non-malignant cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a26f19ab1c49127c9b01c374cae3ce0
https://archive-ouverte.unige.ch/unige:92576

Zobrazit plný text záznamu

18F-FLT and 125I-IdUrd uptake increase in human tumour cell lines induced by the thymidylate synthase inhibitor FdUrd

Autor: Tobias Ludwig Ross, David Viertl, Pierre-Alain André, Florence Perillo-Adamer, A. Bischof Delaloye, Marek Kosinski, Simon M. Ametamey, F. Buchegger, Yves M. Dupertuis

Publikováno v: Nuklearmedizin. 51:163-169

Summary Aim: 5-fluoro-2′-deoxyuridine (FdUrd) depletes the endogenous 5′-deoxythymidine triphosphate (dTTP) pool. We hypothesized whether uptake of exogenous dThd analogues could be favoured through a feedback enhanced salvage pathway and studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::194127ef3e2ba3d3138848d7c9c4834d
https://doi.org/10.3413/nukmed-0459-12-01

Zobrazit plný text záznamu

BARD1 mediates TGF-β signaling in pulmonary fibrosis

Autor: Stephanie Carnesecchi, Rachel C. Chambers, Constance Barazzone-Argiroffo, Cecilia M. Prêle, Irmgard Irminger-Finger, Bruno Crestani, Geoffrey J. Laurent, Jean-Claude Pache, Sarah Vierkotten, Melanie Königshoff, Yves Donati, Pierre-Alain André

Publikováno v: Respir. Res. 16:118 (2015)
Respiratory Research, Vol. 16 (2015) P. 118
Respiratory Research

Background Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a06af944e41221e41004aa0a7814e03
https://doi.org/10.1186/s12931-015-0278-3

Zobrazit plný text záznamu

Antitumour effects of single or combined monoclonal antibodies directed against membrane antigens expressed by human B cells leukaemia

Autor: David Viertl, Franz Buchegger, Pierre-Alain André, Jean-Pierre Mach, Josée Golay, Jean Kadouche, Christian Berthou, Marek Kosinski, Angelika Bischof Delaloye, Laurence Boumsell, Séverine Loisel, Martine Cerutti, Luca Bologna

Publikováno v: Molecular Cancer, Vol 10, Iss 1, p 42 (2011)
Molecular Cancer
Molecular Cancer, BioMed Central, 2011, 10 (1), pp.42. 〈10.1186/1476-4598-10-42〉
Molecular Cancer, BioMed Central, 2011, 10 (1), pp.42. ⟨10.1186/1476-4598-10-42⟩
Molecular Cancer, 2011, 10 (1), pp.42. ⟨10.1186/1476-4598-10-42⟩
Molecular Cancer, vol. 10, pp. 42

Background The increasing availability of different monoclonal antibodies (mAbs) opens the way to more specific biologic therapy of cancer patients. However, despite the significant success of therapy in breast and ovarian carcinomas with anti-HER2 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d42000b5435dccb640ce6670978fa1c
http://www.molecular-cancer.com/content/10/1/42

Zobrazit plný text záznamu

BARD1: an independent predictor of survival in non-small cell lung cancer

Autor: Vera Piera Leoni, Nicolina De Rosa, Renato Versace, Pierre-Alain André, Irmgard Irminger-Finger, Alvin M. Malkinson, Michel Boulvain, Andrea Bianco, Geoffrey J. Laurent, Gianni Frau, Yong Qiang Zhang, Luigi Atzori

Publikováno v: International Journal of Cancer, Vol. 131, No 1 (2012) pp. 83-94
International journal of cancer. Journal international du cancer

BRCA1 mRNA overexpression is correlated with poor survival in NSCLC. However, BRCA1 functions depend on the interaction with BARD1 for its stability, nuclear localization and ubiquitin ligase activity. Expression of alternatively spliced BARD1 isofor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f25615de0db3a8633a76862b16d4d0c
https://pubmed.ncbi.nlm.nih.gov/21815143

Zobrazit plný text záznamu

Possible misinterpretation of the mode of action of therapeutic antibodies in vitro: homotypic adhesion and flow cytometry result in artefactual direct cell death

Autor: Laurence Boumsell, Jean-Pierre Mach, Franz Buchegger, Martino Introna, Josée Golay, Luca Bologna, Pierre-Alain André

Publikováno v: Blood, Vol. 116, No 17 (2010) pp. 3372-3373; author reply 3373-3374

To the editor: Two groups have recently proposed that type II anti-CD20 monoclonal antibodies (mAbs) B1 (tositumomab) and GA101, as well as anti–HLA-DR antibody (L243), induce strong homotypic adhesion and direct cell death. They claim, on the basi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995c914528c4bb59258c0b9af347bda6
https://archive-ouverte.unige.ch/unige:20970

Zobrazit plný text záznamu

Abstract 2296: An isoform of BARD1, associated with many types of cancer, is a driver of oncogenesis by inducing telomere aberrations in vitro and in vivo

Autor: Maxim Pilyugin, Irmgard Irminger-Finger, Magdalena Ratajska, Pierre-Alain André

Publikováno v: Cancer Research. 75:2296-2296

BARD1 has tumor suppressor functions by binding to BRCA1 and to p53 via RING finger and ankyrin repeats, respectively. The BARD1-BRCA1 heterodimer has E3 ligase activity, and the BARD1-p53 interaction promotes apoptosis. The expression of N-terminall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2726e7a9fa1868a731e2a60a815a320c
https://doi.org/10.1158/1538-7445.am2015-2296

Zobrazit plný text záznamu

Additional file 1: Table S1. of BARD1 mediates TGF-β signaling in pulmonary fibrosis

Autor: Pierre-Alain André, Prêle, Cecilia, Vierkotten, Sarah, Carnesecchi, Stéphanie, Donati, Yves, Chambers, Rachel, Pache, Jean-Claude, Crestani, Bruno, Barazzone-Argiroffo, Constance, Königshoff, Melanie, Laurent, Geoffrey, Irminger-Finger, Irmgard

Table S1 shows a list of transcription factors that bind to the BARD1 promoter sequence and are relevant to TGF-β signaling. Figure S1. BARD1 is overexpressed in response to hypoxia. Lung epithelial cells (human A549) and fibroblasts (mouse L929) we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaac430b06a2b8f465850512790289d0

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání