Výsledky vyhledávání - "Pierre Zwiegers"

Akademický článek

Disparity of outcomes: the limits of modeling amyotrophic lateral sclerosis in murine models and translating results clinically

Autor: Pierre Zwiegers, Christopher A Shaw

Publikováno v: Journal of Controversies in Biomedical Research, Vol 1, Iss 1, Pp 4-22 (2015)

Amyotrophic lateral sclerosis (ALS) is a devastatingly progressive neurodegenerative disorder with multiple underlying etiological factors contributing to disease pathogenesis. Despite intensive research efforts and therapeutic development, disease p

Externí odkaz: https://doaj.org/article/6fbe7723fe2140dfad20dc180fa8cbdb

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Reduction in hSOD1 copy number significantly impacts ALS phenotype presentation in G37R (line 29) mice: implications for the assessment of putative therapeutic agents

Autor: Christopher A. Shaw, Pierre Zwiegers, Grace Lee

Publikováno v: Journal of Negative Results in Biomedicine

Background In vivo animal models of familial amyotrophic lateral sclerosis (fALS) are widely used to delineate the potential role that genetic mutations play in the neurodegenerative process. While these models are extensively used for establishing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada0dc5229ad3024fc52ee5b05f5a8b6
http://europepmc.org/articles/PMC4134475

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