Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Pierre Yves Abecassis"'
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
1022 gene signature from RNAseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10eddd92e318753beaf14063960214f
https://doi.org/10.1158/1535-7163.22520766
https://doi.org/10.1158/1535-7163.22520766
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
Primary treatment for estrogen receptor-positive (ER+) breast cancer is endocrine therapy. However, substantial evidence indicates a continued role for ER signaling in tumor progression. Selective estrogen receptor degraders (SERD), such as fulvestra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b86af78b2f4b0ea0bc017ba86b84056
https://doi.org/10.1158/1535-7163.c.6542763
https://doi.org/10.1158/1535-7163.c.6542763
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
supplemental methods, data and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3813137435b6e50ede54df16b76c6dfc
https://doi.org/10.1158/1535-7163.22520769.v1
https://doi.org/10.1158/1535-7163.22520769.v1
Autor:
Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud
Publikováno v:
Journal of Medicinal Chemistry. 63:512-528
More than 75% of breast cancers are estrogen receptor alpha (ERα) positive (ER+), and resistance to current hormone therapies occurs in one-third of ER+ patients. Tumor resistance is still ERα-dependent, but mutations usually confer constitutive ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b8e31876cd3009f301f509589bd98
https://doi.org/10.1021/acs.jmedchem.9b01293
https://doi.org/10.1021/acs.jmedchem.9b01293
Autor:
Corinne Lafon, Amélie Dommergue, Thomas Rooney, Dominique Lesuisse, Thy Phuong Hieu Luc, Anne Olivier, Pierre-Yves Abecassis, Luc Even, Véronique Taupin, Patrick Lardenois, Xavier Vigé, Marie-Noëlle Castel, Florian Auger, Yannick Evanno, Andre Malanda, Marie-Claude Burgevin, Pascal Barneoud, Céline Cegarra, Antonio Almario, Joanna Tsi, Pascale Brunel, Jean-Francois Peyronel, Danielle De-Peretti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:929-932
In the course of a programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson’s disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da24f03facfdd36275110ac060ed5915
https://doi.org/10.1016/j.bmcl.2019.01.024
https://doi.org/10.1016/j.bmcl.2019.01.024
Autor:
Youssef El-Ahmad, Hong Cheng, Fabienne Thompson, Monsif Bouaboula, Jack Pollard, Gary Mccort, Andrew Hebert, Carlos Garcia-Echeverria, Michel Tabart, Fangxian Sun, Laurent Schio, Joon Sang Lee, Dinesh S. Bangari, Jane Cheng, Laurent Besret, Hui Cao, Dietmar Hoffmann, Maysoun Shomali, Rosalia Arrebola, Zhuyan Guo, Anne Caron, Laurent Debussche, Frank Halley, Bruno Filoche-Romme, Albane Courjaud, Mikhail Levit, Malvika Koundinya, Jessica McManus, Victor Certal, Pierre-Yves Abecassis
Publikováno v:
Molecular cancer therapeutics. 20(2)
Primary treatment for estrogen receptor-positive (ER+) breast cancer is endocrine therapy. However, substantial evidence indicates a continued role for ER signaling in tumor progression. Selective estrogen receptor degraders (SERD), such as fulvestra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a793f8b26300e48375f0775740c17d0
https://pubmed.ncbi.nlm.nih.gov/33310762
https://pubmed.ncbi.nlm.nih.gov/33310762
Autor:
Dominique Lesuisse, Pierre-Yves Abecassis, Andre Malanda, Pascale Brunel, Véronique Taupin, Xavier Vigé, Pascal Barneoud
Publikováno v:
Data in Brief, Vol 27, Iss, Pp-(2019)
Data in Brief
Data in Brief
This article describes the chemical synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel Nurr1/NOT agonist. It is meant as a support to an article recently published in Bioorganic and Medicinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94abed80b19cfd09a901811d7c560040
http://www.sciencedirect.com/science/article/pii/S2352340919304111
http://www.sciencedirect.com/science/article/pii/S2352340919304111
Autor:
Benoit Pasquier, Youssef El-Ahmad, Bruno Filoche-Rommé, Christine Dureuil, Florence Fassy, Pierre-Yves Abecassis, Magali Mathieu, Thomas Bertrand, Tsiala Benard, Cédric Barrière, Samira El Batti, Jean-Philippe Letallec, Véronique Sonnefraud, Maurice Brollo, Laurence Delbarre, Véronique Loyau, Fabienne Pilorge, Luc Bertin, Patrick Richepin, Jérôme Arigon, Jean-Robert Labrosse, Jacques Clément, Florence Durand, Romain Combet, Pierre Perraut, Vincent Leroy, Frédéric Gay, Dominique Lefrançois, François Bretin, Jean-Pierre Marquette, Nadine Michot, Anne Caron, Christelle Castell, Laurent Schio, Gary McCort, Hélène Goulaouic, Carlos Garcia-Echeverria, Baptiste Ronan
Publikováno v:
Journal of Medicinal Chemistry. 58:376-400
Vps34 (the human class III phosphoinositide 3-kinase) is a lipid kinase involved in vesicle trafficking and autophagy and therefore constitutes an interesting target for cancer treatment. Because of the lack of specific Vps34 kinase inhibitors, we ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f364d6dcf08b486db73cd403e73d3b1
https://doi.org/10.1021/jm5013352
https://doi.org/10.1021/jm5013352
Autor:
Jean Pierre Marquette, Andreas Karlsson, Sylvie Monget, Thomas Bertrand, Jean Christophe Carry, Frank Halley, Marc Antoine Perrin, Jean Paul Nicolas, Tsiala Benard, Angela Virone-Oddos, Luc Bertin, Céline Amara, Hélène Bonnevaux, Laurence Delbarre, Gilles Doerflinger, Pierre Yves Abecassis, Youssef El-Ahmad, Véronique Charrier, Victor Certal, Bruno Filoche-Romme, Florence Gruss-Leleu, Sébastien Perron, Alexey Rak, Patrick Richepin, Stephane Guerif, Carlos Garcia-Echeverria, Loic Vincent, Nadine Michot, Magali Mathieu, Véronique Loyau, Olivier Lemaitre, Maurice Brollo, Christoph Lengauer, Houlfa Guizani, Laurent Schio, Fabienne Thompson, Cécile Delorme
Publikováno v:
Journal of Medicinal Chemistry. 57:903-920
Compelling molecular biology publications have reported the implication of phosphoinositide kinase PI3Kβ in PTEN-deficient cell line growth and proliferation. These findings supported a scientific rationale for the development of PI3Kβ-specific inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85553ea8c69d86eeaefddb3c7297b6
https://doi.org/10.1021/jm401642q
https://doi.org/10.1021/jm401642q
Autor:
Gary McCort, Rosalia Arrebola, Loreley Calvet, Baptiste Ronan, Fabrice Vergne, Francis Duffieux, Alexey Rak, Isabelle Meaux, David Papin, Florence Fassy, Cecile Delorme, Magali Matthieu, Jean-Paul Nicolas, Christophe Marcireau, Valerie Steier, Pierre-Yves Abecassis, Valerie Czepczor, Heather A. Thomson, Christopher D. Hupp, J.P. Guilinger, Ying Zhang, Anthony D. Keefe, John W. Cuozzo, Julie Liu, Laurent Debussche
Publikováno v:
Cancer Research. 79:3070-3070
From a screening of 27 106 covalent DNA-encoded compound library, a novel KRAS G12C chemical series has been identified. Original hit series compound displayed low µM covalent binding activity to KRAS G12C under GDP form associated with a k(inact)/K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cad2d9863f8a3a9d67e7a56774e2a777
https://doi.org/10.1158/1538-7445.am2019-3070
https://doi.org/10.1158/1538-7445.am2019-3070