Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Pierre Wins"'
Autor:
Margaux Sambon, Aurore Napp, Alice Demelenne, Julie Vignisse, Pierre Wins, Marianne Fillet, Lucien Bettendorff
Publikováno v:
Heliyon, Vol 5, Iss 5, Pp e01710- (2019)
Background: Benfotiamine (BFT) is a synthetic thiamine precursor with high bioavailability. It is efficient in treating complications of type 2 diabetes and has beneficial effects in mouse models of neurodegenerative diseases. The mechanism of action
Externí odkaz:
https://doaj.org/article/32294e98f5cf48efbdfe77fec7e1d49e
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5418 (2021)
Thiamine (vitamin B1) is essential for brain function because of the coenzyme role of thiamine diphosphate (ThDP) in glucose and energy metabolism. In order to compensate thiamine deficiency, several thiamine precursors with higher bioavailability we
Externí odkaz:
https://doaj.org/article/28482e0ed5ab42c9b2445c7c7e4a6389
Autor:
Margaux Sambon, Anna Gorlova, Alice Demelenne, Judit Alhama-Riba, Bernard Coumans, Bernard Lakaye, Pierre Wins, Marianne Fillet, Daniel C. Anthony, Tatyana Strekalova, Lucien Bettendorff
Publikováno v:
Biomedicines, Vol 8, Iss 9, p 361 (2020)
Thiamine precursors, the most studied being benfotiamine (BFT), have protective effects in mouse models of neurodegenerative diseases. BFT decreased oxidative stress and inflammation, two major characteristics of neurodegenerative diseases, in a neur
Externí odkaz:
https://doaj.org/article/4aecb58475724012ad89c9b387066ebc
Autor:
Gregory Kohn, David Delvaux, Bernard Lakaye, Anne-Catherine Servais, Georges Scholer, Marianne Fillet, Benjamin Elias, Jean-Michel Derochette, Jacques Crommen, Pierre Wins, Lucien Bettendorff
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43879 (2012)
BACKGROUND: We recently characterized a specific inorganic triphosphatase (PPPase) from Nitrosomonas europaea. This enzyme belongs to the CYTH superfamily of proteins. Many bacterial members of this family are annotated as predicted adenylate cyclase
Externí odkaz:
https://doaj.org/article/1a83124903e84d0ca8f3698ba20ab6b7
Autor:
Marjorie Gangolf, Jan Czerniecki, Marc Radermecker, Olivier Detry, Michelle Nisolle, Caroline Jouan, Didier Martin, Frédéric Chantraine, Bernard Lakaye, Pierre Wins, Thierry Grisar, Lucien Bettendorff
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13616 (2010)
BACKGROUND: Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine monophosphate (ThMP), thiamine triphosphate (Th
Externí odkaz:
https://doaj.org/article/2a66a6bfc27142f0b082163f693e0c78
Autor:
Lucien Bettendorff, Natalyia Markova, Elena F. Shevtsova, Bernard Coumans, Anna Gorlova, Nicolas Caron, Margaux Sambon, Bernard Lakaye, Pierre Wins, Brigitte Malgrange, Daniel C. Anthony, Natalyia Bazhenova, Tatyana Strekalova, D. A. Pavlov, Andrey A. Svistunov, Julie Vignisse
Publikováno v:
Molecular and Cellular Neuroscience, 82, 126-136. Elsevier Science
Thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). Thiamine precursors with increased bioavailability, especially benfot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1aeb4441180b574d2b297dc8871cc51
https://doi.org/10.1016/j.mcn.2017.05.005
https://doi.org/10.1016/j.mcn.2017.05.005
Publikováno v:
Frontiers in Neuroscience. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc59f1111b5546de8fe28486f6b95600
https://doi.org/10.3389/conf.fnins.2017.94.00102
https://doi.org/10.3389/conf.fnins.2017.94.00102
Publikováno v:
Metabolic Brain Disease. 29:1069-1082
Thiamine triphosphate (ThTP) was discovered over 60 years ago and it was long thought to be a specifically neuroactive compound. Its presence in most cell types, from bacteria to mammals, would suggest a more general role but this remains undefined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da509601381346934dc367f5ddd1657e
https://doi.org/10.1007/s11011-014-9509-4
https://doi.org/10.1007/s11011-014-9509-4
Autor:
Julie Vignisse, Pierre Wins, Marianne Fillet, Margaux Sambon, Aurore Napp, Alice Demelenne, Lucien Bettendorff
Publikováno v:
Heliyon
Heliyon, Vol 5, Iss 5, Pp e01710-(2019)
Heliyon, Vol 5, Iss 5, Pp e01710-(2019)
Background Benfotiamine (BFT) is a synthetic thiamine precursor with high bioavailability. It is efficient in treating complications of type 2 diabetes and has beneficial effects in mouse models of neurodegenerative diseases. The mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bc0902f3a701d29fe5cf115c19c118
https://doi.org/10.1016/j.heliyon.2019.e01710
https://doi.org/10.1016/j.heliyon.2019.e01710
Autor:
Mamidanna R. V.S. Murty, Paulette Charlier, Fabien Heuze, Valérie Gabelica, André Matagne, Edwin De Pauw, Jan Czerniecki, David Delvaux, Raphaël Herman, Lucien Bettendorff, Raphaël Marée, Gregory Kohn, Pierre Wins, Bernard Lakaye, Xavier Tordoir, Frédéric Kerff
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1830:4513-4523
Background Thiamine triphosphate (ThTP) is present in most organisms and might be involved in intracellular signaling. In mammalian cells, the cytosolic ThTP level is controlled by a specific thiamine triphosphatase (ThTPase), belonging to the CYTH s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89997ce342536a4a096d938529ff70d3
https://doi.org/10.1016/j.bbagen.2013.05.014
https://doi.org/10.1016/j.bbagen.2013.05.014