Cardiovascular safety findings in patients with rheumatoid arthritis treated with tofacitinib, an oral Janus kinase inhibitor

Autor: Andrea Zuckerman, M. Boy, Christina Charles-Schoeman, Jamie Geier, Pierre Wicker, R. Riese, Kenneth Kwok, Miguel A. González-Gay, Koshika Soma

Publikováno v: Seminars in Arthritis and Rheumatism 46 (2016) 261-271
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

Objectives Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The implications of treatment with tofacitinib on cardiovascular (CV) risk in RA are unknown. Therefore, CV adverse events (AEs), and blood press

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dc27b379fc9473a0e36ac7cc3a8218
http://hdl.handle.net/10902/11555

Differences in left ventricular structural and functional changes between pheochromocytoma and essential hypertension. Role of elevated circulating catecholamines

Autor: Mitsuhide Imamura, Pierre Wicker, Fetnat M. Fouad-Tarazi, Hassan M.K. Nagi, Michael D. Cressman, Wu-Wei Lin, Gianpaolo Rossi, Emmanuel L. Bravo

Publikováno v: American journal of hypertension. 5(3)

Experimental findings suggest that catecholamines increase protein synthesis and play a role in cardiac hypertrophy. We hypothesize that elevated circulating plasma catecholamines in pheochromocytoma influence cardiac structural and functional remode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fe0a448d76704ee6b298599d66511f
https://pubmed.ncbi.nlm.nih.gov/1533527

Coronary blood flow measurements with left atrial injection of microspheres in conscious rats

Autor: Pierre Wicker, Robert C. Tarazi

Publikováno v: Cardiovascular Research. 16:580-586

Since left atrial (LA) injection of microspheres has been shown to give more precise coronary blood flow (CBF) determinations, and also since studies in a conscious state have obvious advantages, we have developed a technique of chronic LA catheteris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15a319fa21ca3df898c5704284f79d8
https://doi.org/10.1093/cvr/16.10.580

Comparison of the effects of muzolimine and a fixed combination of diuretics in essential hypertension

Autor: Jacques Clementy, Pierre Wicker

Publikováno v: Clinical Pharmacology and Therapeutics. 39:537-542

The efficacy and tolerance of the loop diuretic muzolimine were compared with those of a fixed combination of hydrochlorothiazide and amiloride in patients with mild to moderate hypertension. After a placebo lead-in period, patients whose supine dias

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9045d28c9a29d0fdbce5c052ff8652c
https://doi.org/10.1038/clpt.1986.92

Right ventricular coronary flow in arterial hypertension

Autor: Pierre Wicker, Robert C. Tarazi

Publikováno v: American heart journal. 110(4)

Right ventricular (RV) coronary circulation in systemic hypertension offers an opportunity to assess the effects of marked increases in coronary perfusion pressure in vivo without appreciable increases in workload or marked hypertrophy of the cardiac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461894721a6f60b5338efacb10846434
https://pubmed.ncbi.nlm.nih.gov/2931969