Výsledky vyhledávání - "Pierre Wasnaire"

Vascular Protection and Decongestion Without Renin–Angiotensin–Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist

Autor: Mira Pavkovic, Jörg Hüser, Martina Delbeck, Pierre Wasnaire, Anja Buchmüller, Wilfried Dinh, Thomas Mondritzki, Elisabeth Pook, Hanna Tinel, Axel Kretschmer, Carsten Schmeck, Hubert Truebel, Peter Kolkhof

Publikováno v: Journal of Cardiovascular Pharmacology. 74:44-52

Increased plasma vasopressin levels have been shown to be associated with the progression of congestive heart failure. Vasopressin mediates water retention by renal tubular V2 receptor activation as well as vasoconstriction, cardiac hypertrophy, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ba46fb465addea10690793d97c93fe
https://doi.org/10.1097/fjc.0000000000000677

Zobrazit plný text záznamu

Cardiac output improvement by pecavaptan: a novel dual-acting vasopressin V1a/V2 receptor antagonist in experimental heart failure

Autor: Julia Vogel, Thuy Anh Mai, Elisabeth Pook, Jörg Hüser, Pierre Wasnaire, Hubert Truebel, Wilfried Dinh, Thomas Mondritzki, Peter Kolkhof, Carsten Schmeck

Publikováno v: European journal of heart failure. 23(5)

Aims: Arginine vasopressin (AVP) mediates deleterious effects via vascular V1a and renal V2 receptors in heart failure (HF). Despite positive short-term decongestive effects in phase II HF studies, selective V2 receptor antagonism has shown no long-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b50a07e12f144dfca68405e79cc87a
https://pubmed.ncbi.nlm.nih.gov/33125825

Zobrazit plný text záznamu

An efficient 1,2,4-triazine-based route to the louisianin alkaloids

Autor: Pierre Wasnaire, Richard J. K. Taylor, Nicola Catozzi

Publikováno v: Tetrahedron Letters. 49:2865-2868

A new, short and efficient route to louisianins C and D is described in which the pyridine ring is constructed from a disubstituted 1,2,4-triazine by an inverse-electron-demand Diels–Alder/retro-Diels–Alder/aromatisation cascade sequence. This ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8975266f3febf514479076a8a189c90
https://doi.org/10.1016/j.tetlet.2008.03.026

Zobrazit plný text záznamu

Improved and Practical Procedures for the Preparation of Highly Substituted Pyridines and Pyridazines via Silica-Mediated Aromatisation

Autor: Pierre Wasnaire, Richard J. K. Taylor, William J. Bromley, Nicola Catozzi, Mairi Gibson

Publikováno v: Synlett. 2007:2217-2221

A new and straightforward procedure is described for the preparation of highly substituted pyridines and pyridazines. The method involves a Diels-Alder/retro-Diels-Alder sequence leading to dihydropyridine or related intermediates, which can be aroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef02e506affd2356a935b9150c369e3f
https://doi.org/10.1055/s-2007-984918

Zobrazit plný text záznamu

Reductive cyclisation of Morita–Baylis–Hillman adducts. A simple approach towards substituted hydrindanones and decalones

Autor: Marianne Wiaux, Roland Touillaux, Pierre Wasnaire, István E. Markó

Publikováno v: Tetrahedron Letters. 47:985-989

A connective synthesis of substituted hydrindanones and decalones can be accomplished based upon a novel approach involving two key-steps: a Morita-Baylis-Hillman condensation and an intramolecular reductive cyclisation using lithium in ammonia. Deca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5fd1320dfcff3bf02e0f8b65f57a2e
https://doi.org/10.1016/j.tetlet.2005.11.143

Zobrazit plný text záznamu

Preparation and applications of a novel bis(tributylstannyl)cyclopropane: a synthetic equivalent of a cyclopropane-1,2-dianion

Autor: Eleonóra Kiss, István E. Markó, Mélanie Marchant, Nuno Maulide, Christophe Hermans, Bernard Leroy, Guillaume Berthon-Gelloz, Nicolas Heureux, Sebastien Hermant, Pierre Wasnaire

Publikováno v: Tetrahedron Letters. 46:79-83

The preparation of the novel trans-1,2-bis-stannylcyclopropane 4 is described. Its applications in Kosugi-Migita-Stille cross-coupling and in tin-lithium exchange reactions are presented and discussed. (C) 2004 Elsevier Ltd. All rights reserved.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bd85e3207749e7d2d8d330884289f8
https://doi.org/10.1016/j.tetlet.2004.11.036

Zobrazit plný text záznamu

ChemInform Abstract: Synthesis of the Louisianin Alkaloid Family via a 1,2,4-Triazine Inverse-Electron-Demand Diels-Alder Approach

Autor: Steven A. Raw, Richard J. K. Taylor, Michael G. Edwards, Nicola Catozzi, Pierre Wasnaire

Publikováno v: ChemInform. 41

Isolated in 1995, the four members of the louisianin family (A, B, C and D) are simple pyridine and 2-pyridone alkaloids that display both antibacterial and anticancer activity. Herein we describe the synthesis of all four members of the louisianin f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7cae30bb042340672507a5ce5eca707
https://doi.org/10.1002/chin.201012180

Zobrazit plný text záznamu

Synthesis of the louisianin alkaloid family via a 1,2,4-triazine inverse-electron-demand Diels-Alder approach

Autor: Richard J. K. Taylor, Steven A. Raw, Nicola Catozzi, Pierre Wasnaire, Michael G. Edwards

Publikováno v: The Journal of organic chemistry. 74(21)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34eb2d2d935229fe5d3b436a1cd6bdc
https://pubmed.ncbi.nlm.nih.gov/19780559

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání