Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Pierre Vandurm"'
Autor:
Laszlo Hevesi, Allan Guiguen, Pierre Vandurm, Carine Van Lint, Christelle Cardona, Kiet Le Van, Catherine Michaux, Benoît Georges, Gladys Mbemba, Christine Cauvin, Jean-François Mouscadet, Johan Wouters
Publikováno v:
European Journal of Medicinal Chemistry. 46:1749-1756
New quinolonyl diketo acid compounds bearing various substituents at position 6 of the quinolone scaffold were designed and synthesized as potential HIV-1 integrase inhibitors. These new compounds were evaluated for their antiviral and anti-integrase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f259a89cb440f917d9e2a3267dd85375
https://doi.org/10.1016/j.ejmech.2011.02.028
https://doi.org/10.1016/j.ejmech.2011.02.028
Autor:
Catherine Michaux, Jenny Pouyez, Isabelle Housen, Johan Wouters, Pierre Vandurm, Aurélie Mayard
Publikováno v:
Biochimie. 92:1407-1415
In this study, the crystal structure of a novel endo-1,4-β-xylanase from Scytalidium acidophilum, XYL1, was solved at 1.9. Å resolution. This is one of the few solved crystal structures of acidophilic proteins. The enzyme has the overall fold typic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76de449735fe01f6624d9951c9960011
https://doi.org/10.1016/j.biochi.2010.07.003
https://doi.org/10.1016/j.biochi.2010.07.003
Publikováno v:
Chemical Physics Letters. 478:243-248
In this joint experimental and theoretical study, the solution-state conformation of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoic acid (QDKA), a potential HIV-1 integrase inhibitor, is investigated by using UV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b887e0ea144732795f9e93e9b892b25
https://doi.org/10.1016/j.cplett.2009.07.056
https://doi.org/10.1016/j.cplett.2009.07.056
Autor:
Jenny Pouyez, Louis Maes, Pierre Vandurm, Thomas Verbrugghen, Johan Wouters, Serge Van Calenbergh
Publikováno v:
Journal of medicinal chemistry
To explore the hitherto successful derivatization of the alpha-carbon of fosmidomycin, a series of new a-substituted analogues was prepared. This was done by introduction of a heteroatom (N or O) in alpha-position to the phosphonate and using the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf73c254785428964c3a4e73a9ee2bf
https://hdl.handle.net/10067/1100910151162165141
https://hdl.handle.net/10067/1100910151162165141
Autor:
Allan Guiguen, Pierre Vandurm, Christine Cauvin, Valérie Martinelli, Christelle Cardona, Carine Van Lint, Jean-François Mouscadet, Johan Wouters, Laszlo Hevesi, Gladys Mbemba, Benoît Georges, Kiet Le Van
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
Ethyl [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl]-4-hydroxy-2-oxo-3-butenoate 1 and [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoic acid 2 were synthesized as potential HIV-1 integrase inhibitors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e96b8a0e1aac27b5776b4588d3118c
https://pubmed.ncbi.nlm.nih.gov/19556126
https://pubmed.ncbi.nlm.nih.gov/19556126