Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Pierre V. Candelaria"'
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Akademický článek
Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections
Autor: Brady T. Hickerson, Tracy R. Daniels-Wells, Cristian Payes, Lars E. Clark, Pierre V. Candelaria, Kevin W. Bailey, Eric J. Sefing, Samantha Zink, James Ziegenbein, Jonathan Abraham, Gustavo Helguera, Manuel L. Penichet, Brian B. Gowen
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Five New World mammarenaviruses (NWMs) enter cells via binding to human transferrin receptor 1 (hTfR1). Here, Hickerson et al. show that hTfR1 targeting antibodies partially protect hTfR1-transgenic mice from lethal NWM challenge via competition of a
Externí odkaz: https://doaj.org/article/e61379f33d29440ab73ec6d55d625606
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2
Akademický článek
Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents
Autor: Pierre V. Candelaria, Lai Sum Leoh, Manuel L. Penichet, Tracy R. Daniels-Wells
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf
Externí odkaz: https://doaj.org/article/8b4e515bbd214f91a2e4caef799148c5
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3
Data from Targeting TfR1 with the ch128.1/IgG1 Antibody Inhibits EBV-driven Lymphomagenesis in Immunosuppressed Mice Bearing EBV+ Human Primary B-cells
Autor: Marta Epeldegui, Otoniel Martínez-Maza, Manuel L. Penichet, Pierre V. Candelaria, Larry I. Magpantay, Yu Guo, Tracy R. Daniels-Wells, Laura E. Martínez
Epstein–Barr virus (EBV) is a human gammaherpesvirus associated with the development of hematopoietic cancers of B-lymphocyte origin, including AIDS-related non-Hodgkin lymphoma (AIDS-NHL). Primary infection of B-cells with EBV results in their pol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fd2035a83241542d8f90035515a108
https://doi.org/10.1158/1535-7163.c.6543255
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5
Efficacy of Antibodies Targeting TfR1 in Xenograft Mouse Models of AIDS-Related Non-Hodgkin Lymphoma
Autor: Tracy R. Daniels-Wells, Pierre V. Candelaria, Emiko Kranz, Jing Wen, Lan Wang, Masakazu Kamata, Juan C. Almagro, Otoniel Martínez-Maza, Manuel L. Penichet
Publikováno v: Cancers, vol 15, iss 6
Cancers; Volume 15; Issue 6; Pages: 1816
Transferrin receptor 1 (TfR1), also known as CD71, is a transmembrane protein involved in the cellular uptake of iron and the regulation of cell growth. This receptor is expressed at low levels on a variety of normal cells, but is upregulated on cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fb935e6c15bf3cac7aac18cce95145
https://doi.org/10.3390/cancers15061816
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6
Combination Therapy of an Antibody Specific for Transferrin Receptor 1 (ch128.1/IgG1) with Bortezomib or Lenalidomide Results in Increased Survival in an in vivo Model of Human Multiple Myeloma: A Brief Communication
Autor: Pierre V. Candelaria, Miguel Nava, Otoniel Martínez-Maza, Tracy R. Daniels-Wells, Manuel L. Penichet
Publikováno v: J Immunother
Transferrin receptor 1 (TfR1) is a universal cancer marker and a meaningful target for antibody-based immunotherapy. We previously developed a mouse/human chimeric antibody (ch128.1/IgG1) specific for the human TfR1 and reported that treatment of SCI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2a2913cc31197c86eaf87c5b4f3d2e
https://europepmc.org/articles/PMC9153518/
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7
Targeting TfR1 with the ch128.1/IgG1 antibody inhibits EBV driven lymphomagenesis in immunosuppressed mice bearing EBV(+) human primary B-cells
Autor: Tracy R. Daniels-Wells, Otoniel Martinez-Maza, Marta Epeldegui, Yu Guo, Larry Magpantay, Pierre V. Candelaria, Laura E. Martínez, Manuel L. Penichet
Publikováno v: Mol Cancer Ther
Molecular cancer therapeutics, vol 20, iss 9
Epstein–Barr virus (EBV) is a human gammaherpesvirus associated with the development of hematopoietic cancers of B-lymphocyte origin, including AIDS-related non-Hodgkin lymphoma (AIDS-NHL). Primary infection of B-cells with EBV results in their pol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1540a13a057258862a5f541b3d1d2ef9
https://europepmc.org/articles/PMC8419068/
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8
An IgG1 Version of the Anti-transferrin Receptor 1 Antibody ch128.1 Shows Significant Antitumor Activity Against Different Xenograft Models of Multiple Myeloma: A Brief Communication
Autor: Tracy R. Daniels-Wells, Otoniel Martinez-Maza, Miguel Nava, Manuel L. Penichet, Lai Sum Leoh, Pierre V. Candelaria
Publikováno v: J Immunother
The transferrin receptor 1 (TfR1) is a meaningful target for antibody-based cancer therapy given its overexpression on malignant cells and its central role in cancer pathology. We previously developed a mouse/human chimeric IgG3 targeting human TfR1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dbed50f9fc6d865811b82c483490dc
https://doi.org/10.1097/cji.0000000000000304
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9
Amino acid residues involved in the heparin-binding activity of murine IL-12 in the context of an antibody-cytokine fusion protein
Autor: Rosendo Luria-Pérez, Manuel L. Penichet, Pierre V. Candelaria, Gustavo Helguera, Tracy R. Daniels-Wells, Jose A. Rodriguez
Publikováno v: Cytokine
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
An antibody-cytokine fusion protein, composed of the murine single-chain cytokine interleukin-12 (IL-12) genetically fused to a human IgG3 specific for the human tumor-associated antigen HER2/neu maintains antigen binding, cytokine bioactivity, and I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb02494502dffc89d26bf248fc447d79
https://doi.org/10.1016/j.cyto.2019.04.004
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10
Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections
Autor: Brady T. Hickerson, Tracy R. Daniels-Wells, Cristian Payes, Lars E. Clark, Pierre V. Candelaria, Kevin W. Bailey, Eric J. Sefing, Samantha Zink, James Ziegenbein, Jonathan Abraham, Gustavo Helguera, Manuel L. Penichet, Brian B. Gowen
Publikováno v: Nature Communications
Nature communications, vol 13, iss 1
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Five New World mammarenaviruses (NWMs) cause life-threatening hemorrhagic fever (HF). Cellular entry by these viruses is mediated by human transferrin receptor 1 (hTfR1). Here, we demonstrate that an antibody (ch128.1/IgG1) which binds the apical dom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e169f595bae8bee27c8dbe39db970d59
https://pubmed.ncbi.nlm.nih.gov/35091550
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