Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pierre Scotney"'
Autor:
Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 410-419 (2014)
Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the anti-leukemia
Externí odkaz:
https://doaj.org/article/06924e2c5a1a4bf8928942626539913b
Autor:
Birgitta Sundelin, Ulf Eriksson, Jonas Axelsson, Benjamin Heller Sahlgren, Jaakko Patrakka, Isolde Palombo, Lwaki Ebarasi, Hannes Olauson, Annelie Falkevall, Pierre Scotney, Annika Mehlem, Andrew D. Nash, A. Jimmy Ytterberg, Liqun He
Publikováno v:
Cell Metabolism. 25:713-726
Diabetic kidney disease (DKD) is the most common cause of severe renal disease, and few treatment options are available today that prevent the progressive loss of renal function. DKD is characterized by altered glomerular filtration and proteinuria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15eb9a10b52737d7d00c73106d17a00c
https://doi.org/10.1016/j.cmet.2017.01.004
https://doi.org/10.1016/j.cmet.2017.01.004
Autor:
Paul W. Buehler, Jeremy W. Deuel, Catherine M. Owczarek, Stefan Schauer, Jin Hyen Baek, Matthew P. Hardy, Dominik J. Schaer, Peter Schmidt, Peter Soupourmas, Ayla Yalamanoglu, Pierre Scotney, Christian A. Schaer, Matthias Pelzing
Publikováno v:
BMC Biotechnology
BMC Biotechnology, Vol 18, Iss 1, Pp 1-13 (2018)
BMC Biotechnology, 18 (1)
BMC Biotechnology, Vol 18, Iss 1, Pp 1-13 (2018)
BMC Biotechnology, 18 (1)
Background Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). Proof of concept studies have demonstrated efficacy of Hp in hemolysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32b0cd765098e83a0cca5162aecb7fe
https://doi.org/10.5167/uzh-152406
https://doi.org/10.5167/uzh-152406
Autor:
Matthew P. Hardy, Catherine M. Owczarek, Adele Mount, David Pejoski, Karoline Krstevska, Eugene Maraskovsky, Anabel Silva, Pierre Scotney, Adriana Baz Morelli
Publikováno v:
The Journal of Immunology. 194:2199-2207
The development of therapeutic vaccines for treatment of established cancer has proven challenging. Cancer vaccines not only need to induce a robust tumor Ag-specific immune response but also need to overcome the tolerogenic and immunosuppressive mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26609babe5dcc6239a2c7cd4b4f05ba1
https://doi.org/10.4049/jimmunol.1402228
https://doi.org/10.4049/jimmunol.1402228
Autor:
Rolf Spirig, Adrian Zuercher, Bonnie J. B. Lewis, Jenny Chia, Jason Simmonds, Ian K. Campbell, Tony Rowe, Andreas Hofmann, Donald R. Branch, David Leong, Martin O. Spycher, Chao-Guang Chen, Louis Fabri, Monika Jordi, Con Panousis, Shirley Taylor, Ineke L. Muir, Jennifer Brasseit, Fabian Käsermann, Sandra Koernig, Rebecca E. Butcher, Peter Schmidt, Adriana Baz Morelli, Susann Cattepoel, Pierre Scotney
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(8)
Activation of Fc receptors and complement by immune complexes is a common important pathogenic trigger in many autoimmune diseases and so blockade of these innate immune pathways may be an attractive target for treatment of immune complex-mediated pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa3a7164c9d87af7b6e29ca887ff09b
https://pubmed.ncbi.nlm.nih.gov/29760434
https://pubmed.ncbi.nlm.nih.gov/29760434
Autor:
Matthew P. Hardy, Louis Fabri, Heidi E. Drummer, Matthew A. Perugini, Pierre Scotney, Catherine M. Owczarek, Kathleen McCaffrey, Pantelis Poumbourios, Irene Boo
The hepatitis C virus (HCV) envelope glycoprotein E2 is the major target of broadly neutralizing antibodies in vivo and is the focus of efforts in the rational design of a universal B cell vaccine against HCV. The E2 glycoprotein exhibits a high degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0935f1a87ccb68e690f66d558d840917
https://europepmc.org/articles/PMC5309951/
https://europepmc.org/articles/PMC5309951/
Autor:
Catherine M. Owczarek, Angel F. Lopez, Nicholas J. Wilson, Sophie E. Broughton, Tracy L. Nero, Louis Fabri, Timothy R. Hercus, Urmi Dhagat, Matthew P. Hardy, Andrew D. Nash, Pierre Scotney, Michael W. Parker
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 70:358-361
Interleukin-3 (IL-3) is a member of the beta common family of cytokines that regulate multiple functions of myeloid cells. The IL-3 receptor-specific alpha subunit (IL3Rα) is overexpressed on stem cells/progenitor cells of patients with acute myeloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9f46bd0d1c795a2ac421fe1ded08ac
https://doi.org/10.1107/s2053230x14002593
https://doi.org/10.1107/s2053230x14002593
Autor:
Matthew P. Hardy, Catherine M. Owczarek, Michael Abdo, Genevieve Martin-Roussety, Rebecca E. Butcher, Melanie Louise Ramunno, Pierre Scotney, Louis Fabri, Peter Schmidt, Chao-Guang Chen, Min-Yin Yap
Publikováno v:
Journal of chromatography. A. 1455
Monoclonal antibodies (mAbs) have become the fastest growing segment in the drug market with annual sales of more than 40 billion US$ in 2013. The selection of lead candidate molecules involves the generation of large repertoires of antibodies from w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b29865ea966c4e58b558a0f0ded51a
https://pubmed.ncbi.nlm.nih.gov/27283099
https://pubmed.ncbi.nlm.nih.gov/27283099
Autor:
Henrik Ortsäter, Li Lu, Sofianos Andrikopoulos, Sharon Stone-Elander, Annelie Falkevall, Daniel Nyqvist, Andrew D. Nash, Annika Mehlem, Barbara C Fam, Lars Muhl, Åke Sjöholm, Ulf Eriksson, Carolina E. Hagberg, Joseph Proietto, Erik Samén, Pierre Scotney
Publikováno v:
Nature. 490:426-430
The prevalence of type 2 diabetes is rapidly increasing, with severe socioeconomic impacts. Excess lipid deposition in peripheral tissues impairs insulin sensitivity and glucose uptake, and has been proposed to contribute to the pathology of type 2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d148e973e9a053b3fe191254705289dc
https://doi.org/10.1038/nature11464
https://doi.org/10.1038/nature11464
Autor:
Pierre Scotney, Yazad Irani, Keryn A. Williams, Sonja Klebe, Lauren A. Mortimer, Andrew D. Nash
Publikováno v:
Investigative Opthalmology & Visual Science. 58:3404
Purpose We tested the ability of an antibody fragment with specificity for vascular endothelial growth factor-B (VEGF-B) to regress nascent and established corneal blood vessels in the rat. Methods A single chain variable antibody fragment (scFv) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b6a0d34c623cd5c7dc50666ef76cdd
https://doi.org/10.1167/iovs.16-21343
https://doi.org/10.1167/iovs.16-21343