Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Pierre Santucci"'
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2306-2323 (2023)
Mycobacterium tuberculosis (Mtb), the aetiologic agent of tuberculosis (TB), stores triacylglycerol (TAG) in the form of intrabacterial lipid inclusions (ILI) to survive and chronically persist within its host. These highly energetic molecules repres
Externí odkaz:
https://doaj.org/article/1e77b87ecca44550b6803ae598950173
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1204-1217 (2023)
Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) have evolved diverse strategies to counteract macrophage defence mechanisms including phagolysosomal biogenesis. Within macrophages, Mtb initially resides inside membrane‐bound phagos
Externí odkaz:
https://doaj.org/article/48ccaad7467f4b5b89f634f0ce83e8fc
Autor:
Ona Kandolo, Yassine Cherrak, Isaac Filella-Merce, Hugo Le Guenno, Artemis Kosta, Leon Espinosa, Pierre Santucci, Christophe Verthuy, Régine Lebrun, Michael Nilges, Riccardo Pellarin, Eric Durand
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011687 (2023)
A. baumannii can rapidly acquire new resistance mechanisms and persist on abiotic surface, enabling the colonization of asymptomatic human host. In Acinetobacter the type VI secretion system (T6SS) is involved in twitching, surface motility and is us
Externí odkaz:
https://doaj.org/article/363107d940d64677bc61cceaaadd580f
Autor:
Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott M. Bernard, Nourdine Bah, Mariana Silva Dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James I. MacRae, Maria Greco, Thomas Reinheckel, Matthias Trost, Maximiliano G. Gutierrez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Extensive lysosomal damage can result in cell death but how limited protease leakage affects cytoplasmic organelles in viable cells is not well understood. Here the authors show that limited lysosomal damage leads to changes in the mitochondrial prot
Externí odkaz:
https://doaj.org/article/1b0eea4b126e4d9fbd71cb879e06a954
Autor:
Pierre Santucci, Daniel J. Greenwood, Antony Fearns, Kai Chen, Haibo Jiang, Maximiliano G. Gutierrez
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Effective chemotherapies against tuberculosis must kill the pathogen’s intracellular population. Here, Santucci et al. show that bacterial localisation within human macrophages impact pyrazinamide (PZA) accumulation and efficacy, and that combinati
Externí odkaz:
https://doaj.org/article/f78b658f091740388c9796a7a5393a12
Autor:
Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Mycobacterium tuberculosis segregates within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accumulation, and efficacy. However, it remains unclear
Externí odkaz:
https://doaj.org/article/2c0c7d95b85240ef84d2a4ae39af13bd
Autor:
Pierre Santucci, Matt D. Johansen, Vanessa Point, Isabelle Poncin, Albertus Viljoen, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract Mycobacteria share with other actinomycetes the ability to produce large quantities of triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known as lipid droplets (LD). Mycobacterium tuberculosis (M. tb),
Externí odkaz:
https://doaj.org/article/eb69c7de1ea843358a1eaec12b8e4091
Autor:
Laurence Delattre, Marta Debolini, Jean Christophe Paoli, Claude Napoleone, Michel Moulery, Lara Leonelli, Pierre Santucci
Publikováno v:
Land, Vol 9, Iss 12, p 518 (2020)
Farm abandonment and over-extensification trends in less-favored livestock breeding areas in the Mediterranean have led to socio-environmental issues that are difficult to assess and address, due to the characteristics of these areas (e.g., poor data
Externí odkaz:
https://doaj.org/article/a00665a16ed64ba7a84347526d421ab4
Autor:
Pierre Santucci, Feriel Bouzid, Nabil Smichi, Isabelle Poncin, Laurent Kremer, Chantal de Chastellier, Michel DRANCOURT, Stephane Canaan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)
Despite a slight decline since 2014, tuberculosis (TB) remains the major most deadly infectious disease worldwide with about 1.5 million deaths each year and with about one-third of the population being latently infected with Mycobacterium tuberculos
Externí odkaz:
https://doaj.org/article/7dd0c290cb0c4441a3fa2776baeb1844
Autor:
Valentina Guerrini, Selvakumar Subbian, Pierre Santucci, Stéphane Canaan, Maria Laura Gennaro, Gianni Pozzi
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167989 (2016)
Isolates of the human pathogen Mycobacterium tuberculosis recovered from clinical samples exhibit genetic heterogeneity. Such variation may result from the stressful environment encountered by the pathogen inside the macrophage, which is the host cel
Externí odkaz:
https://doaj.org/article/2c104d1d1bb9453abed9bd8af1e0f5db