Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Pierre R Bushel"'
Autor:
Deepak Mav, Ruchir R Shah, Brian E Howard, Scott S Auerbach, Pierre R Bushel, Jennifer B Collins, David L Gerhold, Richard S Judson, Agnes L Karmaus, Elizabeth A Maull, Donna L Mendrick, B Alex Merrick, Nisha S Sipes, Daniel Svoboda, Richard S Paules
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191105 (2018)
Changes in gene expression can help reveal the mechanisms of disease processes and the mode of action for toxicities and adverse effects on cellular responses induced by exposures to chemicals, drugs and environment agents. The U.S. Tox21 Federal col
Externí odkaz:
https://doaj.org/article/ac4c3100313c431db2f048cc682fb4c1
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMechanistic understanding of transient exposures that lead to adverse health outcomes will enhance our ability to recognize biological signatures of disease. Here, we measured the transcriptomic and epigenomic alterations due to exposure to
Externí odkaz:
https://doaj.org/article/51af5221d82a4dbfae9bc844350e6dd7
Autor:
Barbara J Davis, John I Risinger, Gadisetti V R Chandramouli, Pierre R Bushel, Donna Day Baird, Shyamal D Peddada
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63909 (2013)
The study of uterine leiomyomata (fibroids) provides a unique opportunity to investigate the physiological and molecular determinants of hormone dependent tumor growth and spontaneous tumor regression. We conducted a longitudinal clinical study of pr
Externí odkaz:
https://doaj.org/article/d8e4073e46a445559a6fba9cc0ee0715
Autor:
Pierre R Bushel, Ray McGovern, Liwen Liu, Oliver Hofmann, Ahsan Huda, Jun Lu, Winston Hide, Xihong Lin
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34286 (2012)
Gene expression quantitative trait loci (eQTL) are useful for identifying single nucleotide polymorphisms (SNPs) associated with diseases. At times, a genetic variant may be associated with a master regulator involved in the manifestation of a diseas
Externí odkaz:
https://doaj.org/article/52236a6d3b684166bf220c6c40eedfcc
Autor:
Yong Hwan Jin, Paul E Dunlap, Sandra J McBride, Hanan Al-Refai, Pierre R Bushel, Jonathan H Freedman
Publikováno v:
PLoS Genetics, Vol 4, Iss 4, p e1000053 (2008)
A variety of pathologies are associated with exposure to supraphysiological concentrations of essential metals and to non-essential metals and metalloids. The molecular mechanisms linking metal exposure to human pathologies have not been clearly defi
Externí odkaz:
https://doaj.org/article/3b17fa676c04427db056fd04f758b7e7
Publikováno v:
Cancers, Vol 15, Iss 1, p 285 (2022)
The nitric oxide donor, NCX4040 is a non-steroidal anti-inflammatory-NO donor and has been shown to be extremely cytotoxic to a number of human tumors, including ovarian tumors cells. We have found that NCX4040 is cytotoxic against both OVCAR-8 and i
Externí odkaz:
https://doaj.org/article/a3dd7c178e8a4315bbbaaeaa5fa205f1
Autor:
William K. Kaufmann, Richard S. Paules, Pierre R. Bushel, Feng Cao, Dennis A. Simpson, Yingchun Zhou, Jeff Chou, Tong Zhou
Supplementary Table S1 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353f4819ae0809f91b0962b06ede00f0
https://doi.org/10.1158/1541-7786.22520628
https://doi.org/10.1158/1541-7786.22520628
Autor:
William K. Kaufmann, Richard S. Paules, Pierre R. Bushel, Feng Cao, Dennis A. Simpson, Yingchun Zhou, Jeff Chou, Tong Zhou
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4133a81999fac3e35ea2411300c02e01
https://doi.org/10.1158/1541-7786.c.6542700.v1
https://doi.org/10.1158/1541-7786.c.6542700.v1
Autor:
Michael A. Resnick, Michael B. Fessler, Stavros Garantziotis, Melissa A. Troester, Erin L. Kirk, Maria Shatz, Pierre R. Bushel, Daniel Menendez, Julie M. Lowe
PDF file - 249K, Figure S1. p53 activation by Nutlin-3 induces pro-inflammatory genes. Figure S2. NF-kB plays a role in gene regulation induced by Nutlin-3. Figure S3. Microarray analysis Nutlin-3 and LPS-treated macrophages identifies chemokine gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572e21b214fef0ff96174ede4e57bbc4
https://doi.org/10.1158/0008-5472.22401287.v1
https://doi.org/10.1158/0008-5472.22401287.v1
Autor:
Michael A. Resnick, Michael B. Fessler, Stavros Garantziotis, Melissa A. Troester, Erin L. Kirk, Maria Shatz, Pierre R. Bushel, Daniel Menendez, Julie M. Lowe
PDF file - 63K, Table S1. Responsiveness of pro-inflammatory gene expression to p53 activation. Table S2. GO analysis of commonly regulated genes. Table S3. Conserved transcription factor binding sites in the promoters of commonly regulated genes. Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9748525b48d0c542e91664e7403da45f
https://doi.org/10.1158/0008-5472.22401281
https://doi.org/10.1158/0008-5472.22401281