Výsledky vyhledávání - "Pierre Paulet"

The cGMP/Protein Kinase G Pathway Contributes to Dihydropyridine-sensitive Calcium Response and Cytokine Production in TH2 Lymphocytes

Autor: Franz Hofmann, Gilles Dietrich, Catherine Leclerc, Jean-Charles Guéry, Marilena Djata Cabral, Marc Moreau, Bruno Gomes, Pierre Paulet, Magali Savignac, Lucette Pelletier, Robert Feil

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (18), pp.12421-7. ⟨10.1074/jbc.M510653200⟩

Th2 lymphocytes differ from other CD4+ T lymphocytes not only by their effector tasks but also by their T cell receptor (TCR)-dependent signaling pathways. We previously showed that dihydropyridine receptors (DHPR) involved in TCR-induced calcium inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420fa23ea79edfe32c018e047527560a
https://doi.org/10.1074/jbc.m510653200

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Cutting Edge: T Lymphocyte Activation by Repeated Immunological Synapse Formation and Intermittent Signaling

Autor: Rossana Zaru, Pierre Paulet, Salvatore Valitutti, Sabina Müller, Mustapha Faroudi

Publikováno v: ResearcherID

The activation of biological T cell responses requires prolonged contact with APCs and sustained signaling. We investigated whether signaling must be uninterrupted to commit T cells to cytokine production or whether T cell activation may also result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bf5acff3ffe444e64274845ec15df7
https://doi.org/10.4049/jimmunol.171.3.1128

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Gold is a T cell polyclonal activator in BN and LEW rats but favors IL-4 expression only in autoimmune prone BN rats

Autor: Philippe Druet, Abdelhadi Saoudi, Magali Savignac, Lucette Pelletier, Jean-François Subra, Abdallah Badou, Christelle Delmas, Pierre Paulet, Stéphane De Cramer, Georges Cassar

Publikováno v: European Journal of Immunology. 31:2266-2276

Gold salts are beneficial in the treatment of rheumatoid arthritis but may induce immune-mediated disorders in predisposed patients. Gold salts induce Th2-dependent autoimmunity in Brown-Norway (BN) rats but not in Lewis (LEW) rats. The aim of this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a0f18974ee7f7707e3fc7af5820512
https://doi.org/10.1002/1521-4141(200108)31:8<2266::aid-immu2266>3.0.co

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Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-γ production

Autor: Jean-Charles Guéry, Catherine Leclerc, Dominique Lagrange, Gilles Foucras, Pierre Paulet, Abdallah Badou, Marc Moreau, George Cassar, Magali Savignac, Lucette Pelletier, Philippe Druet

Publikováno v: European Journal of Immunology. 31:2487-2496

Th1 and Th2 cells produce different cytokines and have distinct functions. Th1/Th2 cell differentiation is influenced, among other factors, by the nature of TCR-MHC interactions. However, how the TCR transduces a signal resulting in IFN-gamma or IL-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b980b8a794d75b15eee78ef2097f39c
https://doi.org/10.1002/1521-4141(200108)31:8<2487::aid-immu2487>3.0.co

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Les voies dépendantes du calcium impliquées dans la production de cytokines dans les lymphocytes

Autor: Magali Savignac, Lucette Pelletier, Catherine Leclerc, Pierre Paulet, Marc Moreau, Philippe Druet

Publikováno v: Journal de la Société de Biologie. 195:309-317

Les lymphocytes T CD4+ sont heterogenes en termes de fonctions et de production de cytokines. Les lymphocytes Thl produisent de l’IL-2 et de l’IFNγ et sont impliques dans l’elimination des agents pathogenes intracellulaires. Au contraire, les

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06b6ff09495a524eeaddacac82e13b1b
https://doi.org/10.1051/jbio/2001195030309

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