Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Pierre Pascal Lenck-Santini"'
Autor:
Jeremy M. Barry, Sophie Sakkaki, Sylvain J. Barriere, Katelin P. Patterson, Pierre Pascal Lenck-Santini, Rod C. Scott, Tallie Z. Baram, Gregory L. Holmes
Publikováno v:
EBioMedicine, Vol 7, Iss C, Pp 175-190 (2016)
The coordination of dynamic neural activity within and between neural networks is believed to underlie normal cognitive processes. Conversely, cognitive deficits that occur following neurological insults may result from network discoordination. We hy
Externí odkaz:
https://doaj.org/article/8865ac5e697b4c02bc175adcb1aaa599
Autor:
Erwan Leprince, Robin F. Dard, Salomé Mortet, Caroline Filippi, Marie Giorgi-Kurz, Pierre-Pascal Lenck-Santini, Michel A. Picardo, Marco Bocchio, Agnès Baude, Rosa Cossart
SUMMARYThe adult CA1 region of the hippocampus produces coordinated neuronal dynamics with minimal reliance on its extrinsic inputs. In contrast, the neonatal CA1 is tightly linked to externally-generated sensorimotor activity but the circuit mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48579613bc5fa463a5725aa39da09fe4
https://doi.org/10.1101/2022.06.03.494656
https://doi.org/10.1101/2022.06.03.494656
Autor:
Amanda E. Hernan, Abigail Alexander, Kyle R. Jenks, Jeremy Barry, Pierre-Pascal Lenck-Santini, Elena Isaeva, Gregory L. Holmes, Rod C. Scott
Publikováno v:
Neurobiology of Disease, Vol 63, Iss , Pp 25-34 (2014)
There is a well-described association between childhood epilepsy and pervasive cognitive and behavioral deficits. Often these children not only have ictal EEG events, but also frequent interictal abnormalities. The precise role of these interictal di
Externí odkaz:
https://doaj.org/article/ce7b2806d1fd475ea262edd552d279a0
Autor:
Marie Kurz, Hélène Becq, Pierre-Pascal Lenck-Santini, Emilie Pallesi, Laurent Villard, Mathieu Milh, Laurent Aniksztejn, Najoua Biba
De novo missense variants in the KCNQ2 gene encoding the Kv7.2 subunit of the voltage-gated potassium Kv7/M channel are the main cause of Developmental and Epileptic Encephalopathy (DEE). KCNQ2 related-DEE is characterized by pharmaco-resistant neona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb7f575b0610afafacc4f570f9cd1a3
https://hal-amu.archives-ouvertes.fr/hal-03630409
https://hal-amu.archives-ouvertes.fr/hal-03630409
Autor:
Alex C. Bender, Heather Natola, Christian Ndong, Gregory L. Holmes, Rod C. Scott, Pierre-Pascal Lenck-Santini
Publikováno v:
Neurobiology of Disease, Vol 54, Iss , Pp 297-307 (2013)
Cognitive impairment is a common comorbidity in pediatric epilepsy that can severely affect quality of life. In many cases, antiepileptic treatments fail to improve cognition. Therefore, a fundamental question is whether underlying brain abnormalitie
Externí odkaz:
https://doaj.org/article/4f8ea362dbb549f98384804b67d9669e
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151538 (2016)
Brain oscillations play a critical role in information processing and may, therefore, be essential to uncovering the mechanisms of cognitive impairment in neurological disease. In Dravet syndrome (DS), a mutation in SCN1A, coding for the voltage-gate
Externí odkaz:
https://doaj.org/article/1d8a2445aee6407fad3177c9e2ec9b8f
Publikováno v:
Current Topics in Behavioral Neurosciences
Current Topics in Behavioral Neurosciences, 55, pp.65-106, 2022, ⟨10.1007/7854_2020_193⟩
Psychiatric and Behavioral Aspects of Epilepsy ISBN: 9783031032226
Current Topics in Behavioral Neurosciences, 2021, ⟨10.1007/7854_2020_193⟩
Current Topics in Behavioral Neurosciences, 55, pp.65-106, 2022, ⟨10.1007/7854_2020_193⟩
Psychiatric and Behavioral Aspects of Epilepsy ISBN: 9783031032226
Current Topics in Behavioral Neurosciences, 2021, ⟨10.1007/7854_2020_193⟩
International audience; Epilepsy is commonly associated with cognitive and behavioral deficits that dramatically affect the quality of life of patients. In order to identify novel therapeutic strategies aimed at reducing these deficits, it is critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d318a395dd40c113e93f7847a051cafa
https://hal.science/hal-03118888
https://hal.science/hal-03118888
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132630 (2015)
The dentate gyrus is considered to function as an inhibitory gate limiting excitatory input to the hippocampus. Following status epilepticus (SE), this gating function is reduced and granule cells become hyper-excitable. Dentate spikes (DS) are large
Externí odkaz:
https://doaj.org/article/47cdbaa996e649ea960b088b1f278dfb
Autor:
Pierre-Pascal Lenck-Santini
Publikováno v:
Epilepsy Currents
Epilepsy Currents, Wiley, In press, pp.153575972110018. ⟨10.1177/15357597211001877⟩
Epilepsy Currents, Wiley, In press, pp.153575972110018. ⟨10.1177/15357597211001877⟩
The precise coordination of neuronal activity is critical for optimal brain function. When such coordination fails, this can lead to dire consequences. In this review, I will present evidence that in epilepsy, failed coordination leads not only to se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d2741258e695f262e6c3bb842a6c78
https://hal-amu.archives-ouvertes.fr/hal-03190547
https://hal-amu.archives-ouvertes.fr/hal-03190547
Autor:
Sophie Sakkaki, Sylvain J. Barriere, Pierre-Pascal Lenck-Santini, Rod C. Scott, Alex C. Bender
Publikováno v:
Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2020, 30, pp.5049-5066. ⟨10.1093/cercor/bhaa101⟩
Cerebral Cortex, 2020, 30, pp.5049-5066. ⟨10.1093/cercor/bhaa101⟩
Cerebral Cortex (New York, NY)
Cerebral Cortex, Oxford University Press (OUP), 2020, ⟨10.1093/cercor/bhaa101⟩
Cerebral Cortex, Oxford University Press (OUP), 2020, 30, pp.5049-5066. ⟨10.1093/cercor/bhaa101⟩
Cerebral Cortex, 2020, 30, pp.5049-5066. ⟨10.1093/cercor/bhaa101⟩
Cerebral Cortex (New York, NY)
Cerebral Cortex, Oxford University Press (OUP), 2020, ⟨10.1093/cercor/bhaa101⟩
Alterations in the voltage-gated sodium channel Nav.1.1 are implicated in various neurological disorders, including epilepsy, Alzheimer’s disease, and autism spectrum disorders. Previous studies suggest that the reduction of Nav1.1 expression leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150a3bff9ef44e6e19653f9c66c28216
https://hal.archives-ouvertes.fr/hal-02863810
https://hal.archives-ouvertes.fr/hal-02863810