Zobrazeno 1 - 10 of 168 pro vyhledávání: '"Pierre Pacaud"'
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Akademický článek
Sildenafil-Induced Revascularization of Rat Hindlimb Involves Arteriogenesis through PI3K/AKT and eNOS Activation
Autor: Celine Baron-Menguy, Arnaud Bocquet, Alexis Richard, Anne-Laure Guihot, Bertrand Toutain, Pierre Pacaud, Celine Fassot, Gervaise Loirand, Daniel Henrion, Laurent Loufrani
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 10, p 5542 (2022)
Hypoxia and inflammation play a major role in revascularization following ischemia. Sildenafil inhibits phosphodiesterase-5, increases intracellular cGMP and induces revascularization through a pathway which remains incompletely understood. Thus, we
Externí odkaz: https://doaj.org/article/20b9e82804a64cb3a0d34c1b11db450b
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2
Akademický článek
Hypertension, a Neglected Disease in Rural and Urban Areas in Moramanga, Madagascar.
Autor: Rila Ratovoson, Ony Rabarisoa Rasetarinera, Ionimalala Andrianantenaina, Christophe Rogier, Patrice Piola, Pierre Pacaud
Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0137408 (2015)
Hypertension is one of the main risk factors of cardiovascular diseases. In Madagascar, studies on hypertension in urban and rural communities are scarce.The aim of this study was to determine the prevalence of hypertension and identify associated ri
Externí odkaz: https://doaj.org/article/8706a52340144da29dd25577f002a6ca
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3
Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats
Autor: Gervaise Loirand, Pierre Pacaud, Angela Tesse, Joseph Iharinjaka Randriamboavonjy, Sandrine Heurtebise
Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity
Vascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased endothelial NO⋅ bioavailability and elevated vasoconstrictor and inflammatory mediator production, vascular r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7713e5d045936c1370e3f3370082d78d
https://doaj.org/article/a16499033c5244379017951a3cd95227
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4
Advanced glycation inhibition and protection against endothelial dysfunction induced by coumarins and procyanidins from Mammea neurophylla
Autor: Gilbertine Rakolomalala, Séverine Derbré, Denis Séraphin, Marc Litaudon, Pierre Tonnerre, Patricia Blanchard, Charlotte Gény, Caroline Rouger, Joseph Iharinjaka Randriamboavonjy, Bach Tai Dang, Gervaise Loirand, Pascal Richomme, Béatrice Charreau, Pierre Pacaud
Publikováno v: Fitoterapia
Fitoterapia, Elsevier, 2014, 96, pp.65-75. ⟨10.1016/j.fitote.2014.04.005⟩
International audience; Advanced glycation end-products (AGEs) are associated with many pathogenic disorders such as pathogenesis of diabetes or endothelial dysfunction leading to cardiovascular events. Therefore, the identification of new anti-AGE m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16f15d7b1d212a18f7624f517bbee92
https://doi.org/10.1016/j.fitote.2014.04.005
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5
Cardiac protective effects of Moringa oleifera seeds in spontaneous hypertensive rats
Autor: Angela Tesse, Serge Michalet, Séverine Derbré, Gervaise Loirand, Nathalie Vaillant, Pierre Pacaud, Benjamin Lauzier, Joseph Iharinjaka Randriamboavonjy
Publikováno v: American Journal of Hypertension
American Journal of Hypertension, Oxford University Press (OUP), 2016, 29 (7), pp.873-881. ⟨10.1093/ajh/hpw001⟩
American Journal of Hypertension, Oxford University Press (OUP), 2016, pp.873-881. ⟨10.1093/ajh/hpw001⟩
International audience; BACKGROUND Hypertension is characterized by a maintained high blood pressure leading to cardiac complications such as left ventricular hypertrophy and fibrosis and an increased risk of heart failure and myocardial infarction.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05abe35294e6fe97aba1b55db9777a7
https://hal.archives-ouvertes.fr/hal-01389199
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6
RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension
Autor: David Ferland-McCollough, Antoine Bril, Marianne Rodriguez, Gervaise Loirand, Elizabeth Scalbert, Brian P. Lockhart, Jean-Pierre Galizzi, Pierre Pacaud, Gilliane Chadeuf, Chrystelle Cario-Toumaniantz, Gilles Toumaniantz
Publikováno v: American Journal of Physiology-Cell Physiology. 302:C1394-C1404
Sustained overactivation of RhoA is a common component for the pathogenesis of several cardiovascular disorders, including hypertension. Although activity of Rho proteins depends on Rho exchange factors (Rho-GEFs), the identity of Rho-GEFs expressed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b555d44bc4a3a20bee7d598bb546fc5e
https://doi.org/10.1152/ajpcell.00423.2011
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8
Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells
Autor: Malvyne Rolli-Derkinderen, Jérémy Brégeon, Gervaise Loirand, Pierre Pacaud
Publikováno v: American Journal of Physiology-Cell Physiology. 297:C1062-C1070
Angiotensin II (ANG II) is a major regulator of blood pressure that essentially acts through activation of ANG II type 1 receptor (AT1R) of vascular smooth muscle cells (VSMC). AT1R activates numerous intracellular signaling pathways, including the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6818e8a269f627feed7a22de018359
https://doi.org/10.1152/ajpcell.00174.2009
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9
Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension
Autor: M. Rio, Malvyne Rolli-Derkinderen, Jean-Pierre Savineau, Pierre Pacaud, E. Dumas-De-La-Roque, C Agard, Christine Sagan, Gervaise Loirand
Publikováno v: British Journal of Pharmacology. 158:1285-1294
Background and purpose: Pulmonary arterial hypertension (PAH) is associated with increased contraction and proliferation of pulmonary vascular smooth muscle cells. The anti-diabetic drug metformin has been shown to have relaxant and anti-proliferatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1cc5f0219afad085cebd102878a9c05
https://doi.org/10.1111/j.1476-5381.2009.00445.x
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10
RhoA and Rho Kinase Activation in Human Pulmonary Hypertension
Autor: Christophe Guilluy, Saadia Eddahibi, Marc Humbert, Elie Fadel, Gervaise Loirand, Mohamed Izikki, Pierre Pacaud, Laurent Savale, Christophe Guignabert, Ly Tu, Serge Adnot, Christian Agard
Publikováno v: American Journal of Respiratory and Critical Care Medicine. 179:1151-1158
The complex and multifactorial pathogenesis of pulmonary hypertension (PH) involves constriction, remodeling, and in situ thrombosis of pulmonary vessels. Both serotonin (5-HT) and Rho kinase signaling may contribute to these alterations.To investiga
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1038b5151e396d202cd3db013bedad8
https://doi.org/10.1164/rccm.200805-691oc
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