Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Pierre P. Major"'
Autor:
Lisa A. Santry, Jacob P. van Vloten, Amanda W. K. AuYeung, Robert C. Mould, Jacob G. E. Yates, Thomas M. McAusland, James J. Petrik, Pierre P. Major, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionTumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory ligands and cytokines, and recruitment of immunomodulatory cells, including myel
Externí odkaz:
https://doaj.org/article/0dc2b238fb124dce87ad725117251258
Autor:
Thomas M. McAusland, Jacob P. van Vloten, Lisa A. Santry, Matthew M. Guilleman, Amira D. Rghei, Edgar M. Ferreira, Joelle C. Ingrao, Rozanne Arulanandam, Pierre P. Major, Leonardo Susta, Khalil Karimi, Jean-Simon Diallo, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 306-324 (2021)
The avian paramyxovirus, Newcastle disease virus (NDV), is a promising oncolytic agent that has been shown to be safe and effective in a variety of pre-clinical cancer models and human clinical trials. NDV preferentially replicates in tumor cells due
Externí odkaz:
https://doaj.org/article/e362ae43ee6b4c3790f29c8383e6c1e4
Autor:
Bryce M. Warner, Lisa A. Santry, Alexander Leacy, Mable Chan, Phuc H. Pham, Robert Vendramelli, Yanlong Pei, Nikesh Tailor, Emelissa Valcourt, Anders Leung, Shihua He, Bryan D. Griffin, Jonathan Audet, Marnie Willman, Kevin Tierney, Alixandra Albietz, Kathy L. Frost, Jacob G.E. Yates, Robert C. Mould, Lily Chan, Yeganeh Mehrani, Jason P. Knapp, Jessica A. Minott, Logan Banadyga, David Safronetz, Heidi Wood, Stephanie Booth, Pierre P. Major, Byram W. Bridle, Leonardo Susta, Darwyn Kobasa, Sarah K. Wootton
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103219- (2021)
Summary: The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Newc
Externí odkaz:
https://doaj.org/article/a9d6cd355eb7470ba0489696155667f5
Autor:
Ashley A. Stegelmeier, Lisa A. Santry, Matthew M. Guilleman, Kathy Matuszewska, Jessica A. Minott, Jacob G. E. Yates, Brenna A. Y. Stevens, Sylvia P. Thomas, Sierra Vanderkamp, Kiersten Hanada, Yanlong Pei, Amira D. Rghei, Jacob P. van Vloten, Madison Pereira, Brad Thompson, Pierre P. Major, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 362 (2022)
Epithelial ovarian cancer is the deadliest gynecological malignancy. The lack of effective treatments highlights the need for novel therapeutic interventions. The aim of this study was to investigate whether sustained adeno-associated virus (AAV) vec
Externí odkaz:
https://doaj.org/article/b7a933055d294583b0ee729eeada2323
Autor:
Lisa A. Santry, Thomas M. McAusland, Leonardo Susta, Geoffrey A. Wood, Pierre P. Major, Jim J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 181-191 (2018)
Newcastle disease virus (NDV) is a single-stranded, negative-sense RNA virus in the Paramyxoviridae family. Although primarily an avian pathogen, NDV is a potent oncolytic virus that has been shown to be safe and effective in a variety of preclinical
Externí odkaz:
https://doaj.org/article/3b2b5b0f2d43414d94bc1fcdec5c2f84
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Supplementary Data Figure 2 Supplementary Data, Figure 2. ID8, CAOV-3 and NOSE cells were infected or mock infected (1x PBS) at an MOI of 0.1. Infected and uninfected cells were collected 24 hours later and stained for Annexin V a marker for early ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0342e15dc576617cc2d651ebb17dd1bd
https://doi.org/10.1158/1078-0432.22476029.v1
https://doi.org/10.1158/1078-0432.22476029.v1
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Supplementary Figure 1 Supplementary Data, Figure 1. Combination therapy results in decreased ascites fluid volume. At euthanasia, ascites fluid was aspirated from the abdomen of control and treated mice and the volume was quantified. Combined treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167663a398a0d4060d99d31fdcceadca
https://doi.org/10.1158/1078-0432.22476032
https://doi.org/10.1158/1078-0432.22476032
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Purpose:Intravenous delivery of oncolytic viruses often leads to tumor vascular shutdown, resulting in decreased tumor perfusion and elevated tumor hypoxia. We hypothesized that using 3TSR to normalize tumor vasculature prior to administration of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70162777eeb068f616d113b8fa5e6f1e
https://doi.org/10.1158/1078-0432.c.6529271.v1
https://doi.org/10.1158/1078-0432.c.6529271.v1
Autor:
Pierre P. Major, Robert E. Coleman
Publikováno v:
Seminars in Oncology. 28:17-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c086a650d2e60eae2c8a134581f36cef
https://doi.org/10.1053/sonc.2001.24156
https://doi.org/10.1053/sonc.2001.24156
Autor:
Pierre P. Major
Publikováno v:
Evidence-based Oncology. 2:191-192
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0cfac56e45abdcc9987c323521cb24c
https://doi.org/10.1054/ebon.2001.0150
https://doi.org/10.1054/ebon.2001.0150