Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Pierre N. Tariot"'
Autor:
Stephanie Langella, Kyra Bonta, Yinghua Chen, Yi Su, Daniel Vasquez, David Aguillon, Natalia Acosta-Baena, Ana Y. Baena, Gloria Garcia-Ospina, Margarita Giraldo-Chica, Victoria Tirado, Claudia Muñoz, Silvia Ríos-Romenets, Claudia Guzman-Martínez, Jeremy J. Pruzin, Valentina Ghisays, Joseph F. Arboleda-Velasquez, Kenneth S. Kosik, Pierre N. Tariot, Eric M. Reiman, Francisco Lopera, Yakeel T. Quiroz
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-9 (2024)
Abstract Background Apolipoprotein E (APOE) genotypes have been suggested to influence cognitive impairment and clinical onset in presenilin-1 (PSEN1) E280A carriers for autosomal dominant Alzheimer’s disease (ADAD). Less is known about their impac
Externí odkaz:
https://doaj.org/article/3234fbf9ef1a4a4bae611ce4cce7ba51
Autor:
Pierre N. Tariot, Mercè Boada, Krista L. Lanctôt, Julie Hahn-Pedersen, Firas Dabbous, Sariya Udayachalerm, Lars Lau Raket, Yuliya Halchenko, Wojciech Michalak, Wendy Weidner, Jeffrey Cummings
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression is crucial for evaluating the long-term benefits of disease-modifying treatments. We examined associa
Externí odkaz:
https://doaj.org/article/5d978327cf5b4c69ae31dda83ddacfdb
Autor:
Krista L. Lanctôt, Mercè Boada, Pierre N. Tariot, Firas Dabbous, Julie Hahn‐Pedersen, Sariya Udayachalerm, Lars Lau Raket, Cynthia Saiontz‐Martinez, Wojciech Michalak, Wendy Weidner, Jeffrey Cummings
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION We examined associations between the Clinical Dementia Rating Scale (CDR) and function (Functional Assessment Scale [FAS]), neuropsychiatric symptoms (Neuropsychiatric Inventory Questionnaire [NPI‐Q]), and cognitive impairment
Externí odkaz:
https://doaj.org/article/439da02a121f44439d983700c601118d
Autor:
Angelika Caputo, Amy Racine, Ines Paule, Pierre N. Tariot, Jessica B. Langbaum, Neva Coello, Marie-Emmanuelle Riviere, J. Michael Ryan, Cristina Lopez Lopez, Ana Graf, for the National Alzheimer’s Coordinating Center, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background There is a critical need for novel primary endpoints designed to detect early and subtle changes in cognition in clinical trials targeting the asymptomatic (preclinical) phase of Alzheimer’s disease (AD). The Alzheimer’s Preve
Externí odkaz:
https://doaj.org/article/b6f0a45931354595ad372db4809d8620
Autor:
Jessica B. Langbaum, Noel N. Ellison, Angelika Caputo, Ronald G. Thomas, Carolyn Langlois, Marie-Emmanuelle Riviere, Ana Graf, Cristina Lopez Lopez, Eric M. Reiman, Pierre N. Tariot, Suzanne B. Hendrix
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020)
Abstract Background There is growing interest in identifying sensitive composite cognitive tests to serve as primary endpoints in preclinical Alzheimer’s disease (AD) treatment trials. We reported previously a composite cognitive test score sensiti
Externí odkaz:
https://doaj.org/article/e7c88447f10341739672d2101169bc6e
Autor:
Michael F. Egan, Yuki Mukai, Tiffini Voss, James Kost, Julie Stone, Christine Furtek, Erin Mahoney, Jeffrey L. Cummings, Pierre N. Tariot, Paul S. Aisen, Bruno Vellas, Christopher Lines, David Michelson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Verubecestat, a BACE1 inhibitor that reduces Aβ levels in the cerebrospinal fluid of humans, was not effective in a phase 3 trial (EPOCH) of mild-to-moderate AD and was associated with adverse events. To assist in the development
Externí odkaz:
https://doaj.org/article/b7a42dd59c2848208857c8ea93bf3567
Autor:
Valentina Ghisays, Francisco Lopera, Dhruman D. Goradia, Hillary D. Protas, Michael H. Malek-Ahmadi, Yinghua Chen, Vivek Devadas, Ji Luo, Wendy Lee, Ana Baena, Yamile Bocanegra, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Clara Vila-Castelar, Joshua T. Fox-Fuller, Nan Hu, David Clayton, Ronald G. Thomas, Sergio Alvarez, Alejandro Espinosa, Natalia Acosta-Baena, Margarita M. Giraldo, Silvia Rios-Romenets, Jessica B. Langbaum, Kewei Chen, Yi Su, Pierre N. Tariot, Yakeel T. Quiroz, Eric M. Reiman
Publikováno v:
NeuroImage: Clinical, Vol 31, Iss , Pp 102749- (2021)
Background: In contrast to sporadic Alzheimer’s disease, autosomal dominant Alzheimer’s disease (ADAD) is associated with greater neuropathological evidence of cerebellar amyloid plaque (Aβ) deposition. In this study, we used positron emission t
Externí odkaz:
https://doaj.org/article/ca4232c78c6242d88233825d2f292caa
Autor:
Jeffrey L. Cummings, Alireza Atri, Clive Ballard, Neli Boneva, Lutz Frölich, José Luis Molinuevo, Lars Lau Raket, Pierre N. Tariot
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Globalization of clinical trials has important consequences for trial planning and interpretation. This study investigated heterogeneity in patient characteristics and outcomes among world regions in the global idalopirdine Phase
Externí odkaz:
https://doaj.org/article/6ce97a19860047018f092a523dd33f2a
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 4, Iss 2, Pp 122-124 (2014)
Externí odkaz:
https://doaj.org/article/5bbdb4a0f6f5415a889425b14c81b9ff
Autor:
Clara, Vila-Castelar, Pierre N, Tariot, Kaycee M, Sink, David, Clayton, Jessica B, Langbaum, Ronald G, Thomas, Yinghua, Chen, Yi, Su, Kewei, Chen, Nan, Hu, Margarita, Giraldo-Chica, Carlos, Tobón, Natalia, Acosta-Baena, Ernesto, Luna, Marisol, Londoño, Paula, Ospina, Victoria, Tirado, Claudia, Muñoz, Eliana, Henao, Yamile, Bocanegra, Sergio, Alvarez, Silvia, Rios-Romenets, Valentina, Ghisays, Dhruman, Goradia, Wendy, Lee, Ji, Luo, Michael H, Malek-Ahmadi, Hillary D, Protas, Francisco, Lopera, Eric M, Reiman, Yakeel T, Quiroz
Publikováno v:
Alzheimer's & Dementia. 18:2272-2282
Females may have greater susceptibility to Alzheimer's disease (AD)-pathology. We examined the effect of sex on pathology, neurodegeneration, and memory in cognitively-unimpaired Presenilin-1 (PSEN1) E280A mutation carriers and non-carriers.We analyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b7155417f5e697eab84f968e36aa4e
https://doi.org/10.1002/alz.12552
https://doi.org/10.1002/alz.12552