Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Pierre Maechler"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S251-S252 (2023)
Externí odkaz:
https://doaj.org/article/b8df40aa9b3e48408e7047a5a77557a6
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S365- (2023)
Externí odkaz:
https://doaj.org/article/89f1d7cc2d3d4cbe950eba0f726a99b2
Autor:
Caroline Stekelenburg, Jean-Louis Blouin, Federico Santoni, Norann Zaghloul, Elisabeth A. O’Hare, Rodolphe Dusaulcy, Pierre Maechler, Valerie M. Schwitzgebel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract We identified two NEXMIF variants in two unrelated individuals with non-autoimmune diabetes and autistic traits, and investigated the expression of Nexmif in mouse and human pancreas and its function in pancreatic beta cells in vitro and in
Externí odkaz:
https://doaj.org/article/34e22b0932044412902bc1caf1277407
Autor:
Ozren Stojanović, Jordi Altirriba, Dorothée Rigo, Martina Spiljar, Emilien Evrard, Benedek Roska, Salvatore Fabbiano, Nicola Zamboni, Pierre Maechler, Françoise Rohner-Jeanrenaud, Mirko Trajkovski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Intestinal surface changes in size and function, but what propels these alterations is unknown. Here, the authors show that food excess increases the gut absorptive capacity, and that in presence of dietary lipids, intestinal PPARα is indispensable
Externí odkaz:
https://doaj.org/article/feb666dbd139462abeb8a6b7336b6351
Autor:
Karolina Luczkowska, Caroline Stekelenburg, Frédérique Sloan-Béna, Emmanuelle Ranza, Giacomo Gastaldi, Valérie Schwitzgebel, Pierre Maechler
Publikováno v:
Human Genomics, Vol 14, Iss 1, Pp 1-8 (2020)
Abstract Background Gain-of-function mutations in the GLUD1 gene, encoding for glutamate dehydrogenase (GDH), result in the hyperinsulinism/hyperammonemia HI/HA syndrome. HI/HA patients present with harmful hypoglycemia secondary to protein-induced H
Externí odkaz:
https://doaj.org/article/4b782253b9a346d791f06fefdd06cabe
Autor:
Caroline M. Voss, Lene Arildsen, Jakob D. Nissen, Helle S. Waagepetersen, Arne Schousboe, Pierre Maechler, Peter Ott, Hendrik Vilstrup, Anne B. Walls
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Impaired liver function may lead to hyperammonemia and risk for hepatic encephalopathy. In brain, detoxification of ammonia is mediated mainly by glutamine synthetase (GS) in astrocytes. This requires a continuous de novo synthesis of glutamate, like
Externí odkaz:
https://doaj.org/article/ba69b1e388874ef88afac6aff56a73ff
Autor:
Lucie Oberhauser, Pierre Maechler
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 324 (2021)
Over the last decades, lipotoxicity and glucotoxicity emerged as established mechanisms participating in the pathophysiology of obesity-related type 2 diabetes in general, and in the loss of β-cell function in particular. However, these terms hold v
Externí odkaz:
https://doaj.org/article/f1ea190cbdd040f3b2df34c328ef5e6d
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 541-549 (2017)
Deterioration of pancreatic beta-cells plays a critical role in the development of type 2 diabetes. Among the various stressors contributing to these deleterious effects, glucotoxicity and superoxides have been proposed as major players. In this cont
Externí odkaz:
https://doaj.org/article/2c1b8a312d2b4442b72bef3ebcbc3741
Autor:
Karolina Luczkowska, Caroline Stekelenburg, Frédérique Sloan-Béna, Emmanuelle Ranza, Giacomo Gastaldi, Valérie Schwitzgebel, Pierre Maechler
Publikováno v:
Human Genomics, Vol 15, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/2d3e7d981eb942bf96ea02caa9b53e24
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1543 (2020)
Chronic exposure of β-cells to nutrient-rich metabolic stress impairs mitochondrial metabolism and its coupling to insulin secretion. We exposed isolated human islets to different metabolic stresses for 3 days: 0.4 mM oleate or 0.4 mM palmitate at p
Externí odkaz:
https://doaj.org/article/2e86f76fb78248938120fdfb74d97e16