Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Pierre M. Jean Beltran"'
Autor:
Stephen E. Flaherty, Olivier Bezy, Wei Zheng, Dong Yan, Xiangping Li, Srinath Jagarlapudi, Bina Albuquerque, Ryan M. Esquejo, Matthew Peloquin, Meriem Semache, Arturo Mancini, Liya Kang, Doreen Drujan, Susanne B. Breitkopf, John D. Griffin, Pierre M. Jean Beltran, Liang Xue, John Stansfield, Evanthia Pashos, Quazi Shakey, Christian Pehmøller, Mara Monetti, Morris J. Birnbaum, Jean-Philippe Fortin, Zhidan Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Urocortin 2 (UCN2) acts as a ligand for the G protein-coupled receptor corticotropin-releasing hormone receptor 2 (CRHR2). UCN2 has been reported to improve or worsen insulin sensitivity and glucose tolerance in vivo. Here we show that acute
Externí odkaz:
https://doaj.org/article/c30f771320644d0bb5638ece93bbd9e2
Autor:
Arian Mansur, Remi Joseph, Euri S Kim, Pierre M Jean-Beltran, Namrata D Udeshi, Cadence Pearce, Hanjie Jiang, Reina Iwase, Miroslav P Milev, Hashem A Almousa, Elyshia McNamara, Jeffrey Widrick, Claudio Perez, Gianina Ravenscroft, Michael Sacher, Philip A Cole, Steven A Carr, Vandana A Gupta
Publikováno v:
eLife, Vol 12 (2023)
Ubiquitin-proteasome system (UPS) dysfunction is associated with the pathology of a wide range of human diseases, including myopathies and muscular atrophy. However, the mechanistic understanding of specific components of the regulation of protein tu
Externí odkaz:
https://doaj.org/article/e9f154452fff4bc5b183818788e75991
Autor:
Jeremy M. Robbins, Prashant Rao, Shuliang Deng, Michelle J. Keyes, Usman A. Tahir, Daniel H. Katz, Pierre M. Jean Beltran, François Marchildon, Jacob L. Barber, Bennet Peterson, Yan Gao, Adolfo Correa, James G. Wilson, J. Gustav Smith, Paul Cohen, Robert Ross, Claude Bouchard, Mark A. Sarzynski, Robert E. Gerszten
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in
Externí odkaz:
https://doaj.org/article/724b135f20124b0e94be87ff98faea3a
A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
Autor:
Chi-Hong Wu, Vedakumar Tatavarty, Pierre M Jean Beltran, Andrea A Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A Carr, Jeffrey R Cottrell, Gina G Turrigiano
Publikováno v:
eLife, Vol 11 (2022)
Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of post-translational modifications in this process has not been systematically studied. Using deep-scale quantitative analysi
Externí odkaz:
https://doaj.org/article/62dee5cecd974444b9a59db1da6ab44d
Autor:
Alicja M. Cygan, Pierre M. Jean Beltran, Alma G. Mendoza, Tess C. Branon, Alice Y. Ting, Steven A. Carr, John C. Boothroyd
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Toxoplasma gondii is a ubiquitous, intracellular parasite that envelops its parasitophorous vacuole with a protein-laden membrane (PVM). The PVM is critical for interactions with the infected host cell, such as nutrient transport and immune
Externí odkaz:
https://doaj.org/article/7d01b8bad4c74229ad4e7c136d69e96e
Autor:
Hasmik Keshishian, E Robert McDonald III, Filip Mundt, Randy Melanson, Karsten Krug, Dale A Porter, Luke Wallace, Dominique Forestier, Bokang Rabasha, Sara E Marlow, Judit Jane‐Valbuena, Ellen Todres, Harrison Specht, Margaret Lea Robinson, Pierre M Jean Beltran, Ozgun Babur, Meagan E Olive, Javad Golji, Eric Kuhn, Michael Burgess, Melanie A MacMullan, Tomas Rejtar, Karen Wang, DR Mani, Shankha Satpathy, Michael A Gillette, William R Sellers, Steven A Carr
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Abstract Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here, we present SigPath, a targeted mas
Externí odkaz:
https://doaj.org/article/8c21ac714ff142d89c9c58dde8847a35
Autor:
Joel D. Federspiel, Katelyn C. Cook, Michelle A. Kennedy, Samvida S. Venkatesh, Clayton J. Otter, William A. Hofstadter, Pierre M. Jean Beltran, Ileana M. Cristea
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107943- (2020)
Summary: Nearly all biological processes rely on the finely tuned coordination of protein interactions across cellular space and time. Accordingly, generating protein interactomes has become routine in biological studies, yet interpreting these datas
Externí odkaz:
https://doaj.org/article/24d9ef3d10bb49febc0c2d33cd0a18d3
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Supplementary Methods, Figures, and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08d3edb19dfbd0f47523bcd0445d5d1
https://doi.org/10.1158/2643-3230.22543713.v1
https://doi.org/10.1158/2643-3230.22543713.v1
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Thalidomide analogues exert their therapeutic effects by binding to the CRL4CRBN E3 ubiquitin ligase, promoting ubiquitination and subsequent proteasomal degradation of specific protein substrates. Drug-induced degradation of IKZF1 and IKZF3 in B-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57eb4d478e4fdb51c5ac5ce49a6e60d1
https://doi.org/10.1158/2643-3230.c.6550374.v1
https://doi.org/10.1158/2643-3230.c.6550374.v1
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Supplementary Table 1. Proteomic data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680350b5736d467704658c272205ed4c
https://doi.org/10.1158/2643-3230.22543710.v1
https://doi.org/10.1158/2643-3230.22543710.v1