Zobrazeno 1 - 10
of 374
pro vyhledávání: '"Pierre Legrand"'
Autor:
Véronique Megalizzi, Abdalkarim Tanina, Camille Grosse, Manon Mirgaux, Pierre Legrand, Gaëtan Dias Mirandela, Alexandre Wohlkönig, Pablo Bifani, René Wintjens
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40494- (2024)
MabR (Rv2242), a PucR-type transcription factor, plays a crucial role in regulating mycolic acid biosynthesis in Mycobacterium tuberculosis. To understand its regulatory mechanisms, we determined the crystal structures of its N-terminal and C-termina
Externí odkaz:
https://doaj.org/article/439bd49e186942b88d4665f0fff4e6f4
Autor:
Fouad Ouasti, Maxime Audin, Karine Fréon, Jean-Pierre Quivy, Mehdi Tachekort, Elizabeth Cesard, Aurélien Thureau, Virginie Ropars, Paloma Fernández Varela, Gwenaelle Moal, Ibrahim Soumana-Amadou, Aleksandra Uryga, Pierre Legrand, Jessica Andreani, Raphaël Guerois, Geneviève Almouzni, Sarah Lambert, Francoise Ochsenbein
Publikováno v:
eLife, Vol 12 (2024)
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and functions are st
Externí odkaz:
https://doaj.org/article/e4eaadc73ce04cfaa4c47752fee0fda9
Autor:
Clément Madru, Markel Martínez-Carranza, Sébastien Laurent, Alessandra C. Alberti, Maelenn Chevreuil, Bertrand Raynal, Ahmed Haouz, Rémy A. Le Meur, Marc Delarue, Ghislaine Henneke, Didier Flament, Mart Krupovic, Pierre Legrand, Ludovic Sauguet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Replication Protein A (RPA) is a heterotrimeric single stranded DNA-binding protein with essential roles in DNA replication, recombination and repair. Little is known about the structure of RPA in Archaea, the third domain of life. By using
Externí odkaz:
https://doaj.org/article/8ae48732a3044f69b9e87147a45794c9
Autor:
Ornella Bimai, Pierre Legrand, Jean-Luc Ravanat, Nadia Touati, Jingjing Zhou, Nisha He, Marine Lénon, Frédéric Barras, Marc Fontecave, Béatrice Golinelli-Pimpaneau
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Thiolation of uridine 34 in the anticodon loop of several tRNAs is conserved in the three domains of life and guarantees fidelity of protein translation. U34-tRNA thiolation is catalyzed by a complex of two proteins in the eukaryotic cytosol
Externí odkaz:
https://doaj.org/article/602a88f39c8c47ce862dac8db03055fc
Autor:
Pierre Legrand
Publikováno v:
Revista de Investigações Constitucionais, Vol 10, Iss 1, Pp e231-e231 (2023)
This article challenges four basic and intertwining assumptions informing orthodox comparative law: that a comparatist can exactly represent foreign law; that he can write about foreign law objectively; that he can state the truth regarding foreign l
Externí odkaz:
https://doaj.org/article/6e809145dd00442396447a8c4b22ccb5
Autor:
Pierre Legrand, Yves L. Janin
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 935-943 (2022)
In 1949, Reuben G. Jones disclosed an original synthesis of 2-hydroxypyrazines involving a double condensation between 1,2-dicarbonyls and α-aminoamides upon treatment with sodium hydroxide at low temperature. This discovery turned out to be of impo
Externí odkaz:
https://doaj.org/article/2d3b5a6edb3540eb8540f5d5975bd11a
Autor:
Prashant P. Damke, Louisa Celma, Sumedha M. Kondekar, Anne Marie Di Guilmi, Stéphanie Marsin, Jordane Dépagne, Xavier Veaute, Pierre Legrand, Hélène Walbott, Julien Vercruyssen, Raphaël Guérois, Sophie Quevillon-Cheruel, J. Pablo Radicella
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The ComFC protein is essential for natural transformation, a process that plays a major role in the spread of antibiotic resistance genes. Here the authors show that ComFC is a membrane-associated protein that participates in the transport of DNA thr
Externí odkaz:
https://doaj.org/article/4ad2f5c9255c489b8729c24291247cdd
Autor:
Carole Fruchart Gaillard, Ali Ben Djoudi Ouadda, Lidia Ciccone, Emmanuelle Girard, Sepideh Mikaeeli, Alexandra Evagelidis, Maïlys Le Dévéhat, Delia Susan-Resiga, Evelyne Cassar Lajeunesse, Hervé Nozach, Oscar Henrique Pereira Ramos, Aurélien Thureau, Pierre Legrand, Annik Prat, Vincent Dive, Nabil G. Seidah
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101662- (2023)
Objective: The liver-derived circulating PCSK9 enhances the degradation of the LDL receptor (LDLR) in endosomes/lysosomes. PCSK9 inhibition or silencing is presently used in clinics worldwide to reduce LDL-cholesterol, resulting in lower incidence of
Externí odkaz:
https://doaj.org/article/25b8b2644d1147d09b7ec706733b10c7
Autor:
Pierre Legrand
Publikováno v:
Revista de Investigações Constitucionais, Vol 8, Iss 3, Pp 601-654 (2021)
While much legal research involves foreign law and much of foreign law exists in a foreign language, the issue of translation has attracted limited theoretical attention only. In particular, few lawyers are aware of the work issuing from fields like
Externí odkaz:
https://doaj.org/article/f088d2ee71d543e3bfcef015c59660e4
Autor:
Rania Ghouil, Simona Miron, Lieke Koornneef, Jasper Veerman, Maarten W. Paul, Marie-Hélène Le Du, Esther Sleddens-Linkels, Sari E. van Rossum-Fikkert, Yvette van Loon, Natalia Felipe-Medina, Alberto M. Pendas, Alex Maas, Jeroen Essers, Pierre Legrand, Willy M. Baarends, Roland Kanaar, Sophie Zinn-Justin, Alex N. Zelensky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
BRCA2 and its interactor HSF2BP are required for meiotic recombination. Here, the authors define the interaction structurally, revealing that a repeat in BRCA2 binds two HSF2BP units, increasing the affinity. This region is, however, not essential fo
Externí odkaz:
https://doaj.org/article/0b53e0fe0b894a1fac23825f31a88406