Výsledky vyhledávání - "Pierre Lebrun"

Akademický článek

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP

Autor: Sara Contreras-Martos, Alessandro Piai, Simone Kosol, Mihaly Varadi, Angela Bekesi, Pierre Lebrun, Alexander N. Volkov, Kris Gevaert, Roberta Pierattelli, Isabella C. Felli, Peter Tompa

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract The multi-domain transcriptional coactivators CBP/p300 integrate a multitude of signaling inputs, interacting with more than 400 proteins via one or more of their globular domains. While CBP/p300 function is typically considered in terms of

Externí odkaz: https://doaj.org/article/8a627968a1b743338820c4514ae21356

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Akademický článek

Process analytical technology tools for perfusion cell culture

Autor: Sarah M. Mercier, Perrine M. Rouel, Pierre Lebrun, Bas Diepenbroek, René H. Wijffels, Mathieu Streefland

Publikováno v: Engineering in Life Sciences, Vol 16, Iss 1, Pp 25-35 (2016)

During cell cultivation processes for the production of biopharmaceuticals, good process performance and good product quality can be ensured by online monitoring of critical process parameters (e.g. temperature, pH, or dissolved oxygen). These data c

Externí odkaz: https://doaj.org/article/4610be5198d04be697ed79276c2f96d0

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Akademický článek

Quantification of Intrinsically Disordered Proteins: A Problem Not Fully Appreciated

Autor: Sara Contreras-Martos, Hung H. Nguyen, Phuong N. Nguyen, Nevena Hristozova, Mauricio Macossay-Castillo, Denes Kovacs, Angela Bekesi, Jesper S. Oemig, Dominique Maes, Kris Pauwels, Peter Tompa, Pierre Lebrun

Publikováno v: Frontiers in Molecular Biosciences, Vol 5 (2018)

Protein quantification is essential in a great variety of biochemical assays, yet the inherent systematic errors associated with the concentration determination of intrinsically disordered proteins (IDPs) using classical methods are hardly appreciate

Externí odkaz: https://doaj.org/article/7787bf47f9604572a696bc0107a5a1be

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Akademický článek

Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis.

Autor: Pierre Lebrun, Dominique Raze, Bernd Fritzinger, Jean-Michel Wieruszeski, Franck Biet, Alexander Dose, Mathieu Carpentier, Dirk Schwarzer, Fabrice Allain, Guy Lippens, Camille Locht

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32421 (2012)

BackgroundTuberculosis remains one of the most important causes of global mortality and morbidity, and the molecular mechanisms of the pathogenesis are still incompletely understood. Only few virulence factors of the causative agent Mycobacterium tub

Externí odkaz: https://doaj.org/article/38999e142a404dbb8646e8d32f28d108

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