Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Pierre Le Grevès"'
Autor:
Fred Nyberg, Pierre Le Grevès, Gunnar Lindeberg, Milad Botros, Csaba Tömböly, Géza Tóth, Qin Zhou, Mathias Hallberg, Tobias Johansson
Publikováno v:
Peptides. 29:1820-1824
We have recently identified a specific binding site for the tachykinin peptide substance P (SP) fragment SP(1-7) in the rat spinal cord. This site appeared very specific for SP(1-7) as the binding affinity of this compound highly exceeded those of ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e532b245f1a3faa01e1ead7f57f3b825
https://doi.org/10.1016/j.peptides.2008.05.014
https://doi.org/10.1016/j.peptides.2008.05.014
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 324:759-768
Neurosteroids are endogenous steroids acting in the central nervous system. They participate in synaptic plasticity, memory and learning, Alzheimer's disease, and certain drug reward. Some mechanisms behind these effects are thought to be nongenomic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1ce0e1037e667e3219f5e9e5e4e512
https://doi.org/10.1124/jpet.107.130518
https://doi.org/10.1124/jpet.107.130518
Publikováno v:
Biochemical and Biophysical Research Communications. 357:1028-1033
The age-related decline in gonadal steroids is associated with changes in mood and memory function. It appears that normal physiological concentrations of the steroids are required for adequate synaptic plasticity. However, the effects of high levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da18c92cfdd04b106c0ca330de1f46c
https://doi.org/10.1016/j.bbrc.2007.04.037
https://doi.org/10.1016/j.bbrc.2007.04.037
Autor:
Tobias Johansson, Per-Anders Frändberg, Carolina Birgner, Fred Nyberg, Pierre Le Grevès, Martin Elfverson
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 104:215-219
Activation of the NMDA receptor leads to increased intracellular Ca2+ levels ([Ca2+]i) which induces outgrowth of and morphologic changes in the neurites of the NG108-15 cell line. This effect can be blocked by antagonists for this glutamate receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ad8a05b7c88d6069364285b7077f1a
https://doi.org/10.1016/j.jsbmb.2007.03.024
https://doi.org/10.1016/j.jsbmb.2007.03.024
Publikováno v:
British Journal of Pharmacology. 146:894-902
The modulatory effects of the two neurosteroids pregnenolone sulphate (PS) and pregnanolone sulphate (3α5βS) on [3H]ifenprodil binding to the N-methyl-D-aspartate (NMDA) receptor in rat frontal cortex were studied. The binding for [3H]ifenprodil it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d12b1fa3e47ff300a7cc987e52ce21
https://doi.org/10.1038/sj.bjp.0706397
https://doi.org/10.1038/sj.bjp.0706397
Autor:
Tobias Johansson, Pierre Le Grevès
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 94:263-266
Neurosteroids have been shown to modulate the N-methyl-d-aspartate (NMDA) receptor function. Dehydroepiandrosterone sulfate (DHEAS) is shown to participate in memory and learning processes as well as preventing glutamate neurotoxicity in hippocampus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3e69ccbdb4b5aec91eabc482b741ca
https://doi.org/10.1016/j.jsbmb.2005.01.020
https://doi.org/10.1016/j.jsbmb.2005.01.020
Autor:
Qin Zhou, Fred Nyberg, Madeleine Thörnwall-Le Grevès, Pierre Le Grevès, Wan Huang, Sara Lagerholm
Publikováno v:
Neuroscience Letters. 304:69-72
In this study we have characterized the nucleotide sequence of the cDNA for the growth hormone receptor (GHR) and examined the effects of morphine on the gene transcripts for GHR as well as GH binding protein (GHBP) in the male rat hippocampus and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16da583656bbd6f24c655bf295cc8039
https://doi.org/10.1016/s0304-3940(01)01757-8
https://doi.org/10.1016/s0304-3940(01)01757-8
Publikováno v:
Neuroscience Letters. 291:109-112
Studies have implicated substance P (SP) in the regulation of affective behaviour, memory function, pain influx, stress and opioid reward. All these dimensions are known to involve glutamate transmission mediated through the N-methyl- D -aspartate (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b9e9bfd2c02992d43c5345cf06f9f5
https://doi.org/10.1016/s0304-3940(00)01406-3
https://doi.org/10.1016/s0304-3940(00)01406-3
Publikováno v:
Karolinska Institutet
The expression of the N -methyl- d -aspartate (NMDA) receptor subunits NR1, NR2A and NR2B mRNAs was examined in discrete areas of the male rat brain (including hippocampus, hypothalamus, nucleus accumbens and cortex) following 14 days daily intramusc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fceeecaff28a2a42ea01865d7d364c7a
https://doi.org/10.1016/s0304-3940(97)00244-9
https://doi.org/10.1016/s0304-3940(97)00244-9
Publikováno v:
Neuroscience Research Communications. 19:145-152
The relationship between the NMDA receptor NR1 subunit mRNA and the binding of the NMDA channel ligand [3H]MK-801 was studied during the late embryonic and early postnatal period in various regions of the rat CNS. NR1 mRNA was detectable at embryonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c2985073bd31c0821b80227ffbaaf0
https://doi.org/10.1002/(sici)1520-6769(199611)19:3<145::aid-nrc174>3.0.co
https://doi.org/10.1002/(sici)1520-6769(199611)19:3<145::aid-nrc174>3.0.co