Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

Autor: Jean Guillon, Anita Cohen, Clotilde Boudot, Alessandra Valle, Vittoria Milano, Rabindra Nath Das, Aurore Guédin, Stéphane Moreau, Luisa Ronga, Solène Savrimoutou, Maxime Demourgues, Elodie Reviriego, Sandra Rubio, Sandie Ferriez, Patrice Agnamey, Cécile Pauc, Serge Moukha, Pascale Dozolme, Sophie Da Nascimento, Pierre Laumaillé, Anne Bouchut, Nadine Azas, Jean-Louis Mergny, Catherine Mullié, Pascal Sonnet, Bertrand Courtioux

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 432-459 (2020)

A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro against thr

Externí odkaz: https://doaj.org/article/b7edad286afe4055a84834c680af0464

Synthesis, biological evaluation and membranotropic properties of quinoline-antimicrobial peptide conjugates as antibacterial drugs

Autor: Sandrine Morandat, Karim El Kirat, Sophie Da Nascimento, Pascal Sonnet, Catherine Mullié, Claire Andrejak, François Peltier, Pierre Laumaillé, Alexandra Dassonville-Klimpt, Sandrine Castelain

Publikováno v: Proceedings of 5th International Electronic Conference on Medicinal Chemistry.

Tuberculosis and nosocomial infections are among the most frequent causes of death in the world. Mycobacteria such as Mycobacterium tuberculosis and ESKAPE bacteria are pathogens particularly implicated in these infectious diseases1. The lack of anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27ac907d40cc1ac1d8a81ce1921687f8
https://doi.org/10.3390/ecmc2019-06320

Crystal Structure of 2,8-Bis(trifluoromethyl)-4-vinylquinoline

Autor: Mathieu Marchivie, Pierre Laumaillé, Jean Guillon, Alexandra Dassonville-Klimpt, Stéphane Moreau, Pascal Sonnet

Publikováno v: X-Ray Structure Analysis
X-Ray Structure Analysis Online, Japan Society for Analytical Chemistry's, 2018, 34, pp.15-16. ⟨10.2116/xraystruct.34.15⟩

International audience; The X-ray crystal structure of 2,8-bis(trifluoromethyl)-4-vinylquinoline, a key intermediate in the synthesis of potent antimalarial agents, has been established. It crystallizes in the monoclinic space group P21/c with cell p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6de6a32be08f86b3c73ab44f803fe7a
https://doi.org/10.2116/xraystruct.34.15