Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Pierre Lainee"'
Autor:
Pamela S. Douglas, Jiefen Munley, James Milligan, David E. Gutstein, Eric L. Michelson, Hon-Sum Ko, Philip T. Sager, Pierre Lainee, Jennifer B. Christian, Bonnie Ky, Thomas G. Todaro, Daniel J. Lenihan, Jay W. Mason, Robert C. Kane, Karen A. Hicks, Colette Strnadova, Brenda Ye, Amir Shahlaee, John Finkle, Joel S. Raichlen, Paul D. Hockings, J. Rick Turner, JoAnn Lindenfeld
Publikováno v:
American Heart Journal. 164:846-855
The ability to make informed benefit-risk assessments for potentially cardiotoxic new compounds is of considerable interest and importance at the public health, drug development, and individual patient levels. Cardiac imaging approaches in the evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb7cc9fdc6f17e5f343e2373567b12a
https://doi.org/10.1016/j.ahj.2012.09.001
https://doi.org/10.1016/j.ahj.2012.09.001
Publikováno v:
Toxicology and Applied Pharmacology. 265:200-208
Background: Drugs slowing the conduction of the cardiac action potential and prolonging QRS complex duration by blocking the sodium current (I{sub Na}) may carry pro-arrhythmic risks. Due to the frequency-dependent block of I{sub Na}, this study asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb37c3ad3c14505a45d7540d3195abf3
https://doi.org/10.1016/j.taap.2012.10.007
https://doi.org/10.1016/j.taap.2012.10.007
Autor:
Lorna Ewart, Jean-Pierre Valentin, Karen Philp, Louise Marks, Samantha Borland, Sarah Kirk, Matthew Skinner, Pierre Lainee
Publikováno v:
Toxicology and Applied Pharmacology. 263:171-183
Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a leading cause of drug attrition and post-approval drug withdrawal. A number of cardiovascular screens exist within preclinical development. These screens do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee317915e8569f5e3068042b4466ebb
https://doi.org/10.1016/j.taap.2012.06.007
https://doi.org/10.1016/j.taap.2012.06.007
Publikováno v:
British Journal of Pharmacology. 159:25-33
Non-clinical QT-related assays aligned to the pharmaceutical drug discovery and development phases are used in several ways. During the early discovery phases, assays are used for hazard identification and wherever possible for hazard elimination. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36dd9fc9f8afcaa64e67451f38384b8d
https://doi.org/10.1111/j.1476-5381.2009.00530.x
https://doi.org/10.1111/j.1476-5381.2009.00530.x
Autor:
Matthew Skinner, Pierre Lainee, Dusty Sarazan, Brian Guth, Robert L. Hamlin, Jean-Pierre Valentin
Publikováno v:
Antitargets and Drug Safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890c5a09d84a58b48e0d338dc37727fd
https://doi.org/10.1002/9783527673643.ch10
https://doi.org/10.1002/9783527673643.ch10
Clinical and nonclinical safety liabilities remain a major cause of drug attrition; many of the toxicities are functional in nature and/or in origin and can manifest after single-dose or chronic administration. In recent years there has been a growin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25df1ce1bd94375285924b115c1da584
https://doi.org/10.1016/b978-0-12-417144-2.00022-6
https://doi.org/10.1016/b978-0-12-417144-2.00022-6
Autor:
Olivier Perrault, Elisabeth Patterson, Ludmilla Mazelin-Winum, Florence Pradier, Eric Dufour, Eric Boisserie, Jean-Michel Guillon, Sylvie Bethegnies, Laure Delafoy, Julien Peladan, Pierre Lainee, Erwin Essner, Philippe Vequaud, Clémence Rauch, Serge Burgell, Stéphane Muccio, Aurelie Garcia, Magali Fric-Bordat, Gautier Roussignol, Francoise Meot, Aline Demuynck, Florence Lozano, Mohamed Lemallam, Amelie Falga, Julien Fanelli
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdd33b59c9efc0302a1fcbe69538d54
https://doi.org/10.1016/j.vascn.2017.09.180
https://doi.org/10.1016/j.vascn.2017.09.180
Publikováno v:
Toxicology Letters. 205:S204-S205
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0638bc06ec3901e11885bb4477f60f8e
https://doi.org/10.1016/j.toxlet.2011.05.704
https://doi.org/10.1016/j.toxlet.2011.05.704
Autor:
Chris E. Pollard, Duncan Armstrong, Pierre Lainee, Michael J. Morton, Joanne Bowes, Joanna F. Crouchley, Jean-Pierre Valentin
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e5-e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d46c780a92b16964d77cd19c087b545a
https://doi.org/10.1016/j.vascn.2011.03.024
https://doi.org/10.1016/j.vascn.2011.03.024
Autor:
William S. Redfern, Elizabeth A. Martin, Susan Smith, Pierre Lainee, Olivier Stucker, Helen Prior, Jaimini Reens
Publikováno v:
Toxicology Letters. 229:S238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fcd77bf87479a9586e490733b002e5d
https://doi.org/10.1016/j.toxlet.2014.06.795
https://doi.org/10.1016/j.toxlet.2014.06.795