Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Pierre Lachapelle"'
Autor:
Catherine Argyriou, Anna Polosa, Ji Yun Song, Samy Omri, Bradford Steele, Bruno Cécyre, Devin S. McDougald, Erminia Di Pietro, Jean-François Bouchard, Jean Bennett, Joseph G. Hacia, Pierre Lachapelle, Nancy E. Braverman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 225-240 (2021)
Patients with Zellweger spectrum disorder (ZSD) commonly present with vision loss due to mutations in PEX genes required for peroxisome assembly and function. Here, we evaluate PEX1 retinal gene augmentation therapy in a mouse model of mild ZSD beari
Externí odkaz:
https://doaj.org/article/8cbf07d636cf46afa1661d18efa2eb4c
Autor:
Mercedes Gauthier, Antoine Brassard Simard, Anna Polosa, Allison L. Dorfman, Cynthia X. Qian, Jean-Marc Lina, Pierre Lachapelle
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The electroretinogram (ERG) represents the biopotential evoked by the retina in response to a light stimulus. The flash evoked ERG (fERG) is the ERG modality most frequently used clinically to diagnose and monitor retinal disorders. We hereby present
Externí odkaz:
https://doaj.org/article/c18f1720e1b6414a996470cb5cc85d53
Autor:
Ahmed Dellaa, Maha Benlarbi, Imane Hammoum, Nouha Gammoudi, Mohamed Dogui, Riadh Messaoud, Rached Azaiz, Ridha Charfeddine, Moncef Khairallah, Pierre Lachapelle, Rafika Ben Chaouacha-Chekir
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192400 (2018)
Type 2 diabetic retinopathy is the main cause of acquired blindness in adults. The aim of this work was to examine the retinal function of the sand rat Psammomys obesus as an animal model of diet-induced type 2 diabetes when subjected to a hypercalor
Externí odkaz:
https://doaj.org/article/a37e707bcfe145debbd9bdbf42d33f3a
Autor:
Anna Polosa, Shasha Lv, Wassila Ait Igrine, Laura-Alexie Chevrolat, Hyba Bessaklia, Pierre Lachapelle
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2744 (2019)
To unravel the mechanisms behind the higher resistance to light damage of juvenile (JR) versus adult (AR) rats, Sprague Dawley rats were exposed to a bright luminous environment of 10, 000 lux. The light-induced retinopathy (LIR) was assessed with hi
Externí odkaz:
https://doaj.org/article/100c93f0bb97440bab7f1be8816f7fe2
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158082 (2016)
The purpose of this study was to better understand the role of ocular pigmentation and genetics in light-induced retinal damage. Adult pigmented [Long Evans (LE) and Brown Norway (BN)] and albino [Sprague Dawley (SD) and Lewis (LW)] rats were exposed
Externí odkaz:
https://doaj.org/article/ca2e6c0e64724610a4df72dc4f120d55
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146979 (2016)
In the present study, we aimed at better understanding the short (acute) and long term (chronic) degenerative processes characterizing the juvenile rat model of light-induced retinopathy. Electroretinograms, visual evoked potentials (VEP), retinal hi
Externí odkaz:
https://doaj.org/article/fe04237e5a4841119de91564e63da544
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136056 (2015)
Biological sex and age are considered as two important factors that may influence the function and structure of the retina, an effect that might be governed by sexual hormones such as estrogen. The purpose of this study was to delineate the influence
Externí odkaz:
https://doaj.org/article/77bfc52f1a6948be9279bb53e85da59a
Autor:
Marianne Houssier, William Raoul, Sophie Lavalette, Nicole Keller, Xavier Guillonneau, Barbara Baragatti, Laurent Jonet, Jean-Claude Jeanny, Francine Behar-Cohen, Flavio Coceani, Daniel Scherman, Pierre Lachapelle, Huy Ong, Sylvain Chemtob, Florian Sennlaub
Publikováno v:
PLoS Medicine, Vol 5, Iss 2, p e39 (2008)
BACKGROUND: In the Western world, a major cause of blindness is age-related macular degeneration (AMD). Recent research in angiogenesis has furthered the understanding of choroidal neovascularization, which occurs in the "wet" form of AMD. In contras
Externí odkaz:
https://doaj.org/article/294d600092c349c3b76b3fe387d7bf39
Autor:
Jia Yue You, Allison L. Dorfman, Mathieu Gauvin, Dylan Vatcher, Robert C. Polomeno, John M. Little, Pierre Lachapelle
Publikováno v:
Documenta Ophthalmologica. 146:137-150
Purpose Our study aimed to determine if ISCEV standard-like ERGs recorded with the LKC RETeval® portable ERG unit compared to those obtained using the more traditional tabletop unit. Methods ERGs recorded from normal subjects and patients affected w
Autor:
Jean-François Bouchard, Pierre Lachapelle, Samy Omri, Nancy Braverman, Devin S. McDougald, Ji Yun Song, Erminia Di Pietro, Bruno Cécyre, Catherine Argyriou, Anna Polosa, Joseph G. Hacia, Jean Bennett, Bradford H. Steele
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 225-240 (2021)
Patients with Zellweger spectrum disorder (ZSD) commonly present with vision loss due to mutations in PEX genes required for peroxisome assembly and function. Here, we evaluate PEX1 retinal gene augmentation therapy in a mouse model of mild ZSD beari