Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Pierre Lachapelle"'
Autor:
Catherine Argyriou, Anna Polosa, Ji Yun Song, Samy Omri, Bradford Steele, Bruno Cécyre, Devin S. McDougald, Erminia Di Pietro, Jean-François Bouchard, Jean Bennett, Joseph G. Hacia, Pierre Lachapelle, Nancy E. Braverman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 225-240 (2021)
Patients with Zellweger spectrum disorder (ZSD) commonly present with vision loss due to mutations in PEX genes required for peroxisome assembly and function. Here, we evaluate PEX1 retinal gene augmentation therapy in a mouse model of mild ZSD beari
Externí odkaz:
https://doaj.org/article/8cbf07d636cf46afa1661d18efa2eb4c
Autor:
Mercedes Gauthier, Antoine Brassard Simard, Anna Polosa, Allison L. Dorfman, Cynthia X. Qian, Jean-Marc Lina, Pierre Lachapelle
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The electroretinogram (ERG) represents the biopotential evoked by the retina in response to a light stimulus. The flash evoked ERG (fERG) is the ERG modality most frequently used clinically to diagnose and monitor retinal disorders. We hereby present
Externí odkaz:
https://doaj.org/article/c18f1720e1b6414a996470cb5cc85d53
Autor:
Jia Yue You, Allison L. Dorfman, Mathieu Gauvin, Dylan Vatcher, Robert C. Polomeno, John M. Little, Pierre Lachapelle
Publikováno v:
Documenta Ophthalmologica. 146:137-150
Purpose Our study aimed to determine if ISCEV standard-like ERGs recorded with the LKC RETeval® portable ERG unit compared to those obtained using the more traditional tabletop unit. Methods ERGs recorded from normal subjects and patients affected w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8660bff199391fee44143e910c136389
https://doi.org/10.1007/s10633-022-09903-w
https://doi.org/10.1007/s10633-022-09903-w
Autor:
Jean-François Bouchard, Pierre Lachapelle, Samy Omri, Nancy Braverman, Devin S. McDougald, Ji Yun Song, Erminia Di Pietro, Bruno Cécyre, Catherine Argyriou, Anna Polosa, Joseph G. Hacia, Jean Bennett, Bradford H. Steele
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 225-240 (2021)
Patients with Zellweger spectrum disorder (ZSD) commonly present with vision loss due to mutations in PEX genes required for peroxisome assembly and function. Here, we evaluate PEX1 retinal gene augmentation therapy in a mouse model of mild ZSD beari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27287904ece42349e0b1e5e750c3b06d
https://doi.org/10.1016/j.omtm.2021.09.002
https://doi.org/10.1016/j.omtm.2021.09.002
Autor:
Ahmed Dellaa, Maha Benlarbi, Imane Hammoum, Nouha Gammoudi, Mohamed Dogui, Riadh Messaoud, Rached Azaiz, Ridha Charfeddine, Moncef Khairallah, Pierre Lachapelle, Rafika Ben Chaouacha-Chekir
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192400 (2018)
Type 2 diabetic retinopathy is the main cause of acquired blindness in adults. The aim of this work was to examine the retinal function of the sand rat Psammomys obesus as an animal model of diet-induced type 2 diabetes when subjected to a hypercalor
Externí odkaz:
https://doaj.org/article/a37e707bcfe145debbd9bdbf42d33f3a
Autor:
Jean-Marc Lina, Antoine Brassard-Simard, Mercedes Gauthier, Mathieu Gauvin, Pierre Lachapelle
Publikováno v:
IEEE Transactions on Biomedical Engineering. 68:3173-3183
Goal: The full-field electroretinogram (ffERG) is an objective tool to assess global retinal function, though as it is currently done, it is unable to localize sources of retinal dysfunction or damage. To overcome this, we have developed a new way to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0814188b064868a4930fbceef18280
https://doi.org/10.1109/tbme.2021.3075617
https://doi.org/10.1109/tbme.2021.3075617
Autor:
Anna Polosa, Shasha Lv, Wassila Ait Igrine, Laura-Alexie Chevrolat, Hyba Bessaklia, Pierre Lachapelle
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2744 (2019)
To unravel the mechanisms behind the higher resistance to light damage of juvenile (JR) versus adult (AR) rats, Sprague Dawley rats were exposed to a bright luminous environment of 10, 000 lux. The light-induced retinopathy (LIR) was assessed with hi
Externí odkaz:
https://doaj.org/article/100c93f0bb97440bab7f1be8816f7fe2
Publikováno v:
Documenta Ophthalmologica. 143:1-16
To demonstrate an organic (retinal) amblyogenic defect in functional amblyopes not responding to treatment. Twenty-four children (Mean age: 5.9 ± 1.8 years; range: 4–10 years) with functional amblyopia were recruited for this study. All these chil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f72941bb13d6fbc9aa34a0c2a8c4d2a
https://doi.org/10.1007/s10633-020-09811-x
https://doi.org/10.1007/s10633-020-09811-x
Autor:
Jia Yue, You, Allison L, Dorfman, Mathieu, Gauvin, Dylan, Vatcher, Robert C, Polomeno, John M, Little, Pierre, Lachapelle
Publikováno v:
Documenta ophthalmologica. Advances in ophthalmology.
Our study aimed to determine if ISCEV standard-like ERGs recorded with the LKC RETevalERGs recorded from normal subjects and patients affected with retinal ON and OFF pathway anomalies were compared. Analysis included peak time and amplitude measurem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::932bbca5491a873ff1075a906d852078
https://pubmed.ncbi.nlm.nih.gov/36273363
https://pubmed.ncbi.nlm.nih.gov/36273363
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158082 (2016)
The purpose of this study was to better understand the role of ocular pigmentation and genetics in light-induced retinal damage. Adult pigmented [Long Evans (LE) and Brown Norway (BN)] and albino [Sprague Dawley (SD) and Lewis (LW)] rats were exposed
Externí odkaz:
https://doaj.org/article/ca2e6c0e64724610a4df72dc4f120d55