Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Pierre Koch"'
Autor:
Nicolai Stransky, Katrin Ganser, Leticia Quintanilla-Martinez, Irene Gonzalez-Menendez, Ulrike Naumann, Franziska Eckert, Pierre Koch, Stephan M. Huber, Peter Ruth
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The intermediate-conductance calcium-activated potassium channel KCa3.1 has been proposed to be a new potential target for glioblastoma treatment. This study analyzed the effect of combined irradiation and KCa3.1-targeting with TRAM-34 in th
Externí odkaz:
https://doaj.org/article/0dbdaeb29d4f406cafec13f476947a99
Publikováno v:
Molbank, Vol 2022, Iss 3, p M1418 (2022)
Reaction of diphenylmethanol (4) with n-butyllithium and subsequent treatment with selenium resulted in 12H-dibenzo[d,g][1,2,3]triselenocin-12-ol (5) comprising a novel heterocyclic ring system. The title compound 5 was analyzed by 1H-NMR, 13C-NMR an
Externí odkaz:
https://doaj.org/article/6cc50e6237bb45f799ac8cc021aa26a1
Publikováno v:
Molbank, Vol 2022, Iss 3, p M1437 (2022)
The title compound (S)-3-(3-((7-ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile (2) was synthesized in five steps, starting from 4-chloro-7-iodo-9H-pyrimido[4,5-b]indole (3), and was characterized by 1H-NMR, 13C-NMR, MS and H
Externí odkaz:
https://doaj.org/article/09f9b6b7003d44e386cf2c71cfb3b500
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 264 (2023)
The concept of photocaging represents a promising approach to acquire spatiotemporal control over molecular bioactivity. To apply this strategy to pyridinylimidazole-based covalent JNK3 inhibitors, we used acrylamido-N-(4-((4-(4-(4-fluorophenyl)-1-me
Externí odkaz:
https://doaj.org/article/9a6fd8a70a674c2e9e584d2d2ad88fe1
Publikováno v:
IUCrData, Vol 6, Iss 2, p x210159 (2021)
The title compound, C19H22FN5O, has been synthesized as an inhibitor of glycogen synthase kinase-3β. Two molecules interact via two N—H...N hydrogen bonds, forming centrosymmetric dimers.
Externí odkaz:
https://doaj.org/article/1a7352d38c324c94b49dc79ecd569d7b
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 12361-12368 (2018)
Externí odkaz:
https://doaj.org/article/2420f0fdc1fe4cddae1ec7a593d7acd4
Autor:
Francesco Ansideri, Joana T. Macedo, Michael Eitel, Ahmed El-Gokha, Dhafer S. Zinad, Camilla Scarpellini, Mark Kudolo, Dieter Schollmeyer, Frank M. Boeckler, Bärbel S. Blaum, Stefan A. Laufer, Pierre Koch
Publikováno v:
ACS Omega, Vol 3, Iss 7, Pp 7809-7831 (2018)
Externí odkaz:
https://doaj.org/article/d337085c21624f4fbd7965216a3191ad
Autor:
Friederike A. Steudel, Corinna J. Mohr, Benjamin Stegen, Hoang Y. Nguyen, Andrea Barnert, Marc Steinle, Sandra Beer‐Hammer, Pierre Koch, Wing‐Yee Lo, Werner Schroth, Reiner Hoppe, Hiltrud Brauch, Peter Ruth, Stephan M. Huber, Robert Lukowski
Publikováno v:
Molecular Oncology, Vol 11, Iss 9, Pp 1172-1188 (2017)
Oncogenic signalling via Ca2+‐activated K+ channels of intermediate conductance (SK4, also known as KCa3.1 or IK) has been implicated in different cancer entities including breast cancer. Yet, the role of endogenous SK4 channels for tumorigenesis i
Externí odkaz:
https://doaj.org/article/d69d7c0b9d5d4580b6bcaccda5f3a017
Autor:
Ahmed El-Gokha, Francesco Ansideri, Stanislav Andreev, Dieter Schollmeyer, Stefan Laufer, Pierre Koch
Publikováno v:
Molbank, Vol 2019, Iss 1, p M1048 (2019)
The title compound N1-{4-[2-(methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine (2) was synthesized via nucleophilic aromatic substitution of 2-chloro-4-[2-(methylthio)-1H-imidazol-5-yl]pyridine (3) and p-phenylenediamine under acidic cond
Externí odkaz:
https://doaj.org/article/24022d3a710b4f14aec8322cdf2f9866
Autor:
Christoph Ernst, Johannes Heidrich, Catharina Sessler, Julia Sindlinger, Dirk Schwarzer, Pierre Koch, Frank M. Boeckler
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Phage display-selected bicyclic peptides have already shown their great potential for the development as bioactive modulators of therapeutic targets. They can provide enhanced proteolytic stability and improved membrane permeability. Molecular design
Externí odkaz:
https://doaj.org/article/2e10cff4962d49c689e6eb103dcd1465