Výsledky vyhledávání - "Pierre Jalinot"

Akademický článek

Viral Subversion of the Chromosome Region Maintenance 1 Export Pathway and Its Consequences for the Cell Host

Autor: Makram Mghezzi-Habellah, Léa Prochasson, Pierre Jalinot, Vincent Mocquet

Publikováno v: Viruses, Vol 15, Iss 11, p 2218 (2023)

In eukaryotic cells, the spatial distribution between cytoplasm and nucleus is essential for cell homeostasis. This dynamic distribution is selectively regulated by the nuclear pore complex (NPC), which allows the passive or energy-dependent transpor

Externí odkaz: https://doaj.org/article/fa0ba19ceca940e1a31962f9c2875744

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Akademický článek

The fluorescent protein stability assay: an efficient method for monitoring intracellular protein stability

Autor: Armelle Roisin, Samuel Buchsbaum, Vincent Mocquet, Pierre Jalinot

Publikováno v: BioTechniques, Vol 70, Iss 6, Pp 336-344 (2021)

The stability of intracellular proteins is highly variable, from a few minutes to several hours, and can be tightly regulated to respond to external and internal cellular environment changes. Several techniques can be used to study the stability of a

Externí odkaz: https://doaj.org/article/55f33846a6b0472495d223b36026f47c

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Akademický článek

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

Autor: Francesca Fiorini, Jean-Philippe Robin, Joanne Kanaan, Malgorzata Borowiak, Vincent Croquette, Hervé Le Hir, Pierre Jalinot, Vincent Mocquet

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translo

Externí odkaz: https://doaj.org/article/cee99c9cf6b9423fa0e3aee0a205c4f9

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Akademický článek

The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD)

Autor: Léa Prochasson, Pierre Jalinot, Vincent Mocquet

Publikováno v: Pathogens, Vol 9, Iss 4, p 287 (2020)

Before the establishment of an adaptive immune response, retroviruses can be targeted by several cellular host factors at different stages of the viral replication cycle. This intrinsic immunity relies on a large diversity of antiviral processes. In

Externí odkaz: https://doaj.org/article/187fa804949141c19e0777479ddc58a0

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Akademický článek

PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice.

Autor: Eléonore Pérès, Juliana Blin, Emiliano P Ricci, Maria Artesi, Vincent Hahaut, Anne Van den Broeke, Antoine Corbin, Louis Gazzolo, Lee Ratner, Pierre Jalinot, Madeleine Duc Dodon

Publikováno v: PLoS Pathogens, Vol 14, Iss 3, p e1006933 (2018)

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), an aggressive malignant proliferation of activated CD4+ T lymphocytes. The viral Tax oncoprotein is critically involved in both HTLV-1-repl

Externí odkaz: https://doaj.org/article/b33d76150be5483dae7b901fa4bea860

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