Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Pierre J, De Clercq"'
Publikováno v:
Molecules, Vol 14, Iss 2, Pp 894-903 (2009)
Three analogues of 1a,25-dihydroxyvitamin D3 (calcitriol), featuring a trans-fused decalin C,D-core with local S2-symmetry, and possessing identical side-chain and seco-B,A-ring structures, have been synthesized starting from readily available (4aR,8
Externí odkaz:
https://doaj.org/article/bcbd38568c5f4a6aa110af5adcbeffa4
Autor:
Pierre J. De Clercq, Garrett B. Minne
Publikováno v:
Molecules, Vol 12, Iss 2, Pp 183-187 (2007)
A short and high yielding route for thepreparation of the title compound, starting from commercially available1,5-dihydroxynaphthalene, is described. The key step in the sequence is the airoxidation of a bis(trimethylsilyloxy)diene precursor.
Externí odkaz:
https://doaj.org/article/febc450846c24abc994222f3e292bd0d
Publikováno v:
Molecules, Vol 12, Iss 2, Pp 237-244 (2007)
The asymmetric rhodium-catalysed 1,4-addition of alkenylzirconium reagents to 2-cyclohexenone can be useful in the synthesis of 3-alkenyl-2-methylcyclohexanones, provided that formaldehyde is used in trapping the intermediate zirconium enolates. In t
Externí odkaz:
https://doaj.org/article/5c2057324e6747a483c8f720e596e2f8
Publikováno v:
Molecules, Vol 11, Iss 9, Pp 707-713 (2006)
The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are useful intermediates in natural product synthesis.
Externí odkaz:
https://doaj.org/article/3d2eda9f7ad54461af4cd56976c1ccce
Autor:
Pierre J. De Clercq, Jo N. D'herde
Publikováno v:
Molecules, Vol 11, Iss 8, Pp 655-660 (2006)
An example of the Julia–Lythgoe attachment of the vitamin D side chain to a solid-phase linked Inhoffen–Lythgoe diol derived CD-ring fragment is reported.
Externí odkaz:
https://doaj.org/article/721cc21ddf0446179cb3d97139a37868
Autor:
Ling-Jie Gao, Gunther Van Cauwenberge, Noël Hosten, Dirk Van Haver, Magali Waelbroeck, Pierre J. De Clercq
Publikováno v:
ARKIVOC, Vol 2003, Iss 4, Pp 22-45 (2003)
Externí odkaz:
https://doaj.org/article/21507ec1744a401bb59e5d3d5eafc44e
Autor:
Roger Bouillon, Justine Vanhevel, Lieve Verlinden, Stefanie Doms, Pierre J. De Clercq, Annemieke Verstuyf, Iris Janssens
Bisphosphonates like risedronate inhibit osteoclast-mediated bone resorption and are therefore used in the prevention and treatment of osteoporosis. Also vitamin D3 and calcium supplementation is commonly used in the prevention or treatment of osteop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271c43e56cdd4821303bb111f5bd8c85
https://lirias.kuleuven.be/handle/123456789/633071
https://lirias.kuleuven.be/handle/123456789/633071
Autor:
Veronique Van Speybroeck, Saron Catak, Sebastian Wouters, Pierre J. De Clercq, Michel Waroquier, Hannelore Goossens, Laura Hermosilla, Johan M. Winne
Publikováno v:
JOURNAL OF ORGANIC CHEMISTRY
The thermal equilibration of the methyl esters of endiandric acids D and E was subject to a computational study. An electrocyclic pathway via an electrocyclic ring opening followed by a ring flip and a subsequent electrocyclization proposed by Nicola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b494a7f49ca39e432c7558bddf421dab
https://doi.org/10.1021/jo5027639
https://doi.org/10.1021/jo5027639
Autor:
Michel Van Overschelde, Annemieke Verstuyf, Duchan Laplace, Pierre J. De Clercq, Johan M. Winne
Publikováno v:
European Journal of Organic Chemistry. 2013:728-735
The synthesis of two new A-ring precursors, useful for the convergent assembly of 2α-ethyl and 2β-ethyl derivatives of 19-nor-1α,25-dihydroxyvitamin D3, is described. These building blocks were prepared in 14 steps from quinic acid, which led to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bb7375cba767187c405d5c554eda5c2
https://doi.org/10.1002/ejoc.201201261
https://doi.org/10.1002/ejoc.201201261
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 97:493-504
Chiral acrylates 4a, 4b and 4c, derived from primary alcohols with a single stereogenic centre, were studied for possible diastereoface differentiation in their Lewis acid catalyzed Diels-Alder reaction with cyclopentadiene. No relevant diastereomeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c26eeb6f3aeb0ec5a88ff01a84837c73
https://doi.org/10.1002/bscb.19880970705
https://doi.org/10.1002/bscb.19880970705