Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Pierre Hardy"'
Publikováno v:
Antioxidants, Vol 13, Iss 6, p 646 (2024)
This study aims to investigate the role of microRNA let-7f in the dysfunction and degeneration of retinal pigment epithelium (RPE) cells through the induction of senescence and oxidative stress. Furthermore, we explore whether let-7f inhibition can p
Externí odkaz:
https://doaj.org/article/d5cf18753ecd4a83a24bd4a80b61266e
Autor:
Victor Passos Gibson, Houda Tahiri, Claudia Gilbert, Chun Yang, Quoc Thang Phan, Xavier Banquy, Pierre Hardy
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 563 (2024)
Lipid nanoparticles (LNPs) have established their position as nonviral vectors for gene therapy. Tremendous efforts have been made to modulate the properties of LNPs to unleash their full clinical potential. Among the strategies being pursued, the la
Externí odkaz:
https://doaj.org/article/d91d7f3a6a9f4775b08225a6352d48cb
Autor:
Chun Yang, Pierre Hardy
Publikováno v:
Cells, Vol 12, Iss 22, p 2594 (2023)
Serine/threonine kinase (AKT) signaling regulates diverse cellular processes and is one of the most important aberrant cell survival mechanisms associated with tumorigenesis, metastasis, and chemoresistance. Targeting AKT has become an effective ther
Externí odkaz:
https://doaj.org/article/2bafa154d63c40a7a4a7e50da3a17f6b
Autor:
Guiju Cai, Yuejiao Wang, Tahiri Houda, Chun Yang, Lijuan Wang, Muqing Gu, Alfred Mueck, Stephane Croteau, Xiangyan Ruan, Pierre Hardy
Publikováno v:
Translational Oncology, Vol 14, Iss 6, Pp 101068- (2021)
Background: Research suggests that hormone replacement therapy may increase the risk of breast cancer, and progestins such as norethisterone (NET) play a key role in this phenomenon. We have demonstrated that microRNA-181a (miR-181a) suppresses NET-p
Externí odkaz:
https://doaj.org/article/a6dd92f65d5242c2a9fb3d39964ec61d
Autor:
Michel Desjarlais, Pakiza Ruknudin, Maëlle Wirth, Isabelle Lahaie, Rabah Dabouz, José Carlos Rivera, Tiffany Habelrih, Samy Omri, Pierre Hardy, Alain Rivard, Sylvain Chemtob
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Background and AimInsufficient post-ischemic neovascularization is an initial key step in the pathogenesis of Oxygen-Induced Retinopathy (OIR). During neovascularization, pro-angiogenic cells (PACs) are mobilized from the bone marrow and integrate in
Externí odkaz:
https://doaj.org/article/8897c27c0d2f4502b53fdb07ee39e51b
Autor:
Michel Desjarlais, Maëlle Wirth, Isabelle Lahaie, Pakiza Ruknudin, Pierre Hardy, Alain Rivard, Sylvain Chemtob
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The coronavirus disease 2019 (COVID-19) pandemic has become the number one health problem worldwide. As of August 2020, it has affected more than 18 million humans and caused over 700,000 deaths worldwide. COVID-19 is an infectious disease that can l
Externí odkaz:
https://doaj.org/article/8fe24b3ba93d4da6aed51fe0bc09a690
Publikováno v:
Cells, Vol 11, Iss 10, p 1670 (2022)
Endothelial dysfunction plays a critical role in many human angiogenesis-related diseases, including cancer and retinopathies. Small non-coding microRNAs (miRNAs) repress gene expression at the post-transcriptional level. They are critical for endoth
Externí odkaz:
https://doaj.org/article/98c3c5ff871f46619868a6cb7a66922e
Publikováno v:
Cellular Physiology and Biochemistry, Vol 44, Iss 3, Pp 843-856 (2017)
MicroRNAs (miRNAs) are a family of highly conserved noncoding single˗stranded RNA molecules of 21 to 25 nucleotides. miRNAs silence their cognate target genes at the post-transcriptional level and have been shown to have important roles in oncogenes
Externí odkaz:
https://doaj.org/article/389b870d1c8d4dba889e3805ecf47641
Autor:
Chun Yang, Wei Xiong, Qian Qiu, Houda Tahiri, Rosanne Superstein, Anne-Sophie Carret, Przemyslaw Sapieha, Pierre Hardy
Publikováno v:
Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-10 (2014)
Background: Unregulated cell proliferation or growth is a prominent characteristic of cancer. We have previously demonstrated that LMPs (cell membrane microparticles derived from apoptotic human CEM T lymphoma cells stimulated with actinomycin D) str
Externí odkaz:
https://doaj.org/article/f12d46d7fbcd49078d4cff8d1d38c230
Publikováno v:
Canadian Journal of Gastroenterology, Vol 11, Iss 3, Pp 208-212 (1997)
An 11-year-old boy with eosinophilic gastroenteritis treated by an elimination diet alone presented with a perforated gastroduodenal ulcer subsequent to blunt trauma to the abdomen. Peripheral eosinophilia, chronic iron deficiency, chronic hypoalbumi
Externí odkaz:
https://doaj.org/article/cd9a78b57413413c9448da38fb07226e