Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Pierre Gauffre"'
Autor:
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S. Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The drug AT-527 targets the SARS-CoV-2 replication machinery. Here the authors use Cryo-EM to show how AT-527 inhibits SARS-CoV-2 polymerase by acting as an immediate RNA chain terminator and stably binding in a NiRAN active-site pocket; impeding an
Externí odkaz:
https://doaj.org/article/10c0996a692f427a8bc1883d8ce5e61e
Autor:
Mikael Feracci, Cécilia Eydoux, Véronique Fattorini, Lea Lo Bello, Pierre Gauffre, Barbara Selisko, Priscila Sutto-Ortiz, Ashleigh Shannon, Hongjie Xia, Pei-Yong Shi, Mathieu Noel, Françoise Debart, Jean-Jacques Vasseur, Steve Good, Kai Lin, Adel Moussa, Jean-Pierre Sommadossi, Aurélie Chazot, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, François Ferron, Bruno Canard
Publikováno v:
Antiviral Research
Antiviral Research, 2023, 212, pp.105574. ⟨10.1016/j.antiviral.2023.105574⟩
Antiviral Research, 2023, 212, pp.105574. ⟨10.1016/j.antiviral.2023.105574⟩
International audience; AT-752 is a guanosine analogue prodrug active against dengue virus (DENV). In infected cells, it is metabolized into 2 '-methyl-2 '-fluoro guanosine 5 '-triphosphate (AT-9010) which inhibits RNA synthesis in acting as a RNA ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e83f8c477b054811808f29f63f4776
https://doi.org/10.1016/j.antiviral.2023.105574
https://doi.org/10.1016/j.antiviral.2023.105574
Autor:
Bhawna Sama, Etienne Decroly, Paolo La Colla, Barbara Selisko, Steven S. Good, Jean-Pierre Sommadossi, Adrien Delpal, Camille Falcou, Adel Moussa, Kai Lin, Hui Shi, Ashleigh Shannon, Bruno Canard, Cécilia Eydoux, Yingxao Zhu, Karine Alvarez, Pierre Gauffre, Xiaodong Yan, Veronique Fattorini, Priscila El-Kazzi, Mikael Feracci, François Ferron, Jean-Claude Guillemot
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Nature Communications
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩
Nature Communications
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩
A worldwide effort is ongoing to discover drugs against the Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2), which has so far caused >3.5 million fatalities (https://covid19.who.int/). The virus essential RNA-dependent RNA polymeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14f01f1609abb1a795a7309150f5ca4
https://doi.org/10.21203/rs.3.rs-624370/v1
https://doi.org/10.21203/rs.3.rs-624370/v1
Autor:
Kai Lin, Etienne Decroly, Françoise Debart, Nadia Rabah, Bhawna Sama, Jean-Claude Guillemot, Bruno Canard, Hui Shi, Ashleigh Shannon, Cécilia Eydoux, Jean-Jacques Vasseur, Yingxiao Zhu, François Ferron, Camille Falcou, Mikael Feracci, A. Moussa, Jean-Pierre Sommadossi, Karine Toulon, Barbara Selisko, Mathieu Noël, Steven S. Good, Pierre Gauffre, Priscila El Kazzi, Xiaodong Yan, Veronique Fattorini
SummaryHow viruses from the Coronaviridae family initiate viral RNA synthesis is unknown. Here we show that the SARS-CoV-1 and −2 Nidovirus RdRp-Associated Nucleotidyltransferase (NiRAN) domain on nsp12 uridylates the viral cofactor nsp8, forming a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e1d77f43ab95d6f58607895a539c39
https://doi.org/10.1101/2021.03.23.436564
https://doi.org/10.1101/2021.03.23.436564