Molecular Tuning of Filamin A Activities in the Context of Adhesion and Migration

Autor: Isabelle Lamsoul, Loïc Dupré, Pierre G. Lutz

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

The dynamic organization of actin cytoskeleton meshworks relies on multiple actin-binding proteins endowed with distinct actin-remodeling activities. Filamin A is a large multi-domain scaffolding protein that cross-links actin filaments with orthogon

Externí odkaz: https://doaj.org/article/69edf7d2dd3d46f19ae9498b197c5544

Supplementary Figure legends from The E3 Ubiquitin Ligase Asb2α in T Helper 2 Cells Negatively Regulates Antitumor Immunity in Colorectal Cancer

Autor: Pierre G. Lutz, Christel Moog-Lutz, Chanaëlle Febrissy, Arnaud Métais, Isabelle Lamsoul, Camille A. Spinner

Supplementary Figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef04e9fbf866ae1c30368cf9fc2279ab
https://doi.org/10.1158/2326-6066.22542171.v1

Data from The E3 Ubiquitin Ligase Asb2α in T Helper 2 Cells Negatively Regulates Antitumor Immunity in Colorectal Cancer

Autor: Pierre G. Lutz, Christel Moog-Lutz, Chanaëlle Febrissy, Arnaud Métais, Isabelle Lamsoul, Camille A. Spinner

The escape of cancer cells from host immunosurveillance involves a shift in immune responses, including an imbalance in Th1 and Th2 cells. A Th1-dominated immune response predicts positive outcomes in colorectal cancer. The E3 ubiquitin ligase, Asb2�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc4bb5c61bacb9e3f2e303147eab29e
https://doi.org/10.1158/2326-6066.c.6549825.v1

Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Autor: Pierre G. Lutz, Dongjian Hu, Christel Moog-Lutz, Sheraz Ditta, Ibrahim J. Domian, Patrick T. Ellinor, Jan W. Buikema, Nikhil Mittal, Abir Yamak

Publikováno v: iScience
iScience, 2020, 23 (3), pp.100959. ⟨10.1016/j.isci.2020.100959⟩
iScience, Vol 23, Iss 3, Pp-(2020)
iScience, Elsevier, 2020, 23 (3), pp.100959. ⟨10.1016/j.isci.2020.100959⟩

Summary Defining the pathways that control cardiac development facilitates understanding the pathogenesis of congenital heart disease. Herein, we identify enrichment of a Cullin5 Ub ligase key subunit, Asb2, in myocardial progenitors and differentiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f37adb6550ecb62562f5c859c5450d
https://hal-cnrs.archives-ouvertes.fr/hal-03019023

Filamins regulate cell spreading and initiation of cell migration.

Autor: Massimiliano Baldassarre, Ziba Razinia, Clara F Burande, Isabelle Lamsoul, Pierre G Lutz, David A Calderwood

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e7830 (2009)

Mammalian filamins (FLNs) are a family of three large actin-binding proteins. FLNa, the founding member of the family, was implicated in migration by cell biological analyses and the identification of FLNA mutations in the neuronal migration disorder

Externí odkaz: https://doaj.org/article/9450d93359cc4463a14180b8d4b563be