Výsledky vyhledávání - "Pierre Flandin"

Akademický článek

An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females

Autor: Stephanie M. Correa, David W. Newstrom, James P. Warne, Pierre Flandin, Clement C. Cheung, Alexander T. Lin-Moore, Andrew A. Pierce, Allison W. Xu, John L. Rubenstein, Holly A. Ingraham

Publikováno v: Cell Reports, Vol 10, Iss 1, Pp 62-74 (2015)

Estrogen-receptor alpha (ERα) neurons in the ventrolateral region of the ventromedial hypothalamus (VMHVL) control an array of sex-specific responses to maximize reproductive success. In females, these VMHVL neurons are believed to coordinate metabo

Externí odkaz: https://doaj.org/article/801ff2f30d0c4fd4ab3422a6a1c3505c

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Synergistic Combination Activity of the Novel GSPT1 Degrader CC-90009 in Acute Myeloid Leukemia Models

Autor: Emily Pace, Daniel W. Pierce, Soraya Carrancio, Alicia Benitez, Michael Pourdehnad, Matthew Hoffmann, Pierre Flandin-Blety, Carla Guarinos, Jinhong Fan, Hongbin Wang, Tsun-Wen Sheena Yao

Publikováno v: Blood. 138:3330-3330

Introduction: CC-90009 is a novel cereblon E3 ligase modulator (CELMoD ®) agent that is a first-in-class degrader of translation termination factor G1 to S phase transition 1 (GSPT1). CC-90009 has demonstrated antileukemic activity as a single agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8349c68b6bdcde0b87ae18e11c3c37ea
https://doi.org/10.1182/blood-2021-147160

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DDRE-26. TARGETING THE UNFOLDED PROTEIN RESPONSE POTENTIATES MARIZOMIB ANTITUMOR ACTIVITY IN GLIOBLASTOMA

Autor: Laure Escoubet, Pierre Flandin-Blety, Christophe Severin, Nishdallyh Beltran-Raygoza, C Dan Dumitru, Mark Rolfe, Jorge Benitez-Hernandez

Publikováno v: Neuro Oncol

Glioblastoma (GBM) is the most prevalent and aggressive malignant tumor of the central nervous system in adults. Patients with GBM have a poor prognosis, with a median survival of 15 months with current standard-of-care treatment, consisting of surge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159037ec65e2ee8737f8a9f971f6cc7c
https://doi.org/10.1093/neuonc/noaa215.271

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Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons

Autor: Axel Visel, Carol Kim, Linda Su-Feher, Magnus Sandberg, Pierre Flandin, Jia Sheng Hu, J Price, Alexander Nord, Shanni N. Silberberg, John L.R. Rubenstein

Publikováno v: Neuron, vol 91, iss 6
Sandberg, M; Flandin, P; Silberberg, S; Su-Feher, L; Price, JD; Hu, JS; et al.(2016). Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron, 91(6), 1260-1275. doi: 10.1016/j.neuron.2016.08.020. UCSF: Retrieved from: http://www.escholarship.org/uc/item/05c35664

© 2016 The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d49af25839acf81f1c7ba6261df5a1
https://escholarship.org/uc/item/05c35664

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Lhx6 and Lhx8 Coordinately Induce Neuronal Expression of Shh that Controls the Generation of Interneuron Progenitors

Autor: Pierre Flandin, Daniel Vogt, Juhee Jeong, Gregory B. Potter, Yangu Zhao, Heiner Westphal, John L.R. Rubenstein, Jason E. Long

Publikováno v: Neuron. 70:939-950

SUMMARY Lhx6 and Lhx8 transcription factor coexpression in early-born MGE neurons is required to induce neuronal Shh expression. We provide evidence that these transcription factors regulate expression of a Shh enhancer in MGE neurons. Lhx6 and Lhx8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd04ef8fd770926fd8ae68fb7af968d9
https://doi.org/10.1016/j.neuron.2011.04.020

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The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons

Autor: John L.R. Rubenstein, Pierre Flandin, Shioko Kimura

Publikováno v: The Journal of Neuroscience. 30:2812-2823

We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele. The Shh-expressing subpallial lineage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d09fdbc50411a8c795ed9911f2143d5a
https://doi.org/10.1523/jneurosci.4228-09.2010

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Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants

Autor: Melissa Dela Cuesta, Heiner Westphal, Yangu Zhao, Pierre Flandin, Jason E. Long, John L.R. Rubenstein

Publikováno v: The Journal of Comparative Neurology. 510:79-99

Here we analyze the role of the Lhx6 lim-homeobox transcription factor in regulating the development of subsets of neocortical, hippocampal, and striatal interneurons. An Lhx6 loss-of-function allele, which expresses placental alkaline phosphatase (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba07ad779fbfaa036fbef6d77fc78ce3
https://doi.org/10.1002/cne.21772

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An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females

Autor: Pierre Flandin, Allison W. Xu, Holly A. Ingraham, Andrew A. Pierce, Clement C. Cheung, John L.R. Rubenstein, Stephanie M. Correa, David W. Newstrom, Alexander T. Lin-Moore, James P. Warne

Publikováno v: Cell reports, vol 10, iss 1
Cell Reports, Vol 10, Iss 1, Pp 62-74 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5f0efca209dcf1b73372ba58250176
https://escholarship.org/uc/item/5vc019c5

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Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting

Autor: Maria Jimenez, Lorenz Lehr, Jean-Paul Giacobino, Cédric Yvon, Patrick A. Keller, Pierre Flandin, Patrick Muzzin, Bertrand Léger, Françoise Kühne, Aaron P. Russell

Publikováno v: European Journal of Biochemistry. 269:2878-2884

Uncoupling protein-3 (UCP3) is a mitochondrial inner-membrane protein abundantly expressed in rodent and human skeletal muscle which may be involved in energy dissipation. Many studies have been performed on the metabolic regulation of UCP3 mRNA leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80f4e58ddcf9dbd50a2204c5e0759ad2
https://doi.org/10.1046/j.1432-1033.2002.02953.x

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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences

Autor: David V. Hansen, Arturo Alvarez-Buylla, Jan H. Lui, Pierre Flandin, John L.R. Rubenstein, Arnold R. Kriegstein, Kazuaki Yoshikawa

Publikováno v: Nature neuroscience. 16(11)

GABAergic cortical interneurons underlie the complexity of neural circuits and are particularly numerous and diverse in humans. In rodents, cortical interneurons originate in the subpallial ganglionic eminences, but their developmental origins in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c27c48b954a17a01f6e0f1b25ce927
https://pubmed.ncbi.nlm.nih.gov/24165675

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