Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Pierre Dubus"'
Autor:
Marisa M. Faraldo, Mathilde Romagnoli, Loane Wallon, Pierre Dubus, Marie-Ange Deugnier, Silvia Fre
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract Background The aberrant amplification of mammary luminal progenitors is at the origin of basal-like breast cancers associated with BRCA1 mutations. Integrins mediate cell–matrix adhesion and transmit mechanical and chemical signals that dr
Externí odkaz:
https://doaj.org/article/28d9748dffe74913bc09ffa1e4f1d948
Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor
Autor:
Lornella Seeneevassen, Anissa Zaafour, Elodie Sifré, Coralie Genevois, Tra Ly Nguyen, Yasmine Pobiedonoscew, Alban Giese, Jérôme Guignard, Camille Tiffon, Benoit Rousseau, Anne-Aurélie Raymond, Geneviève Belleannée, Hélène Boeuf, Caroline Gronnier, Océane C. B. Martin, Julie Giraud, Philippe Lehours, Pierre Dubus, Christine Varon
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Gastric cancer’s (GC) bad prognosis is usually associated with metastatic spread. Invasive cancer stem cells (CSC) are considered to be the seed of GC metastasis and not all CSCs are able to initiate metastasis. Targeting these aggressive
Externí odkaz:
https://doaj.org/article/f3c91b91bd3d4c56a8a9fbd0497898b6
Autor:
Aya Abou Hammoud, Julie Giraud, Xavier Gauthereau, Camille Blanchard, Sophie Daburon, Marco Zese, Silvia Molina-Castro, Pierre Dubus, Christine Varon, Helene Boeuf
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3293 (2023)
Cancer stem cells are a subpopulation of tumor cells characterized by their ability to self-renew, induce tumors upon engraftment in animals and exhibit strong resistance to chemotherapy and radiotherapy. These cells exhibit numerous characteristics
Externí odkaz:
https://doaj.org/article/e2dc8c60202e4af9b0611adab26d74a3
Autor:
Sylviane Lagarrigue, Isabel C. Lopez-Mejia, Pierre-Damien Denechaud, Xavier Escoté, Judit Castillo-Armengol, Veronica Jimenez, Carine Chavey, Albert Giralt, Qiuwen Lai, Lianjun Zhang, Laia Martinez-Carreres, Brigitte Delacuisine, Jean-Sébastien Annicotte, Emilie Blanchet, Sébastien Huré, Anna Abella, Francisco J. Tinahones, Joan Vendrell, Pierre Dubus, Fatima Bosch, C. Ronald Kahn, Lluis Fajas
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/1453ec066ed340c8a243912c98d2ac0f
Autor:
Sylviane Lagarrigue, Isabel C. Lopez-Mejia, Pierre-Damien Denechaud, Xavier Escoté, Judit Castillo-Armengol, Veronica Jimenez, Carine Chavey, Albert Giralt, Qiuwen Lai, Lianjun Zhang, Laia Martinez-Carreres, Brigitte Delacuisine, Jean-Sébastien Annicotte, Emilie Blanchet, Sébastien Huré, Anna Abella, Francisco J. Tinahones, Joan Vendrell, Pierre Dubus, Fatima Bosch, C. Ronald Kahn, Lluis Fajas
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Externí odkaz:
https://doaj.org/article/4642ee6f471f48639eb3b9f1fb308211
Autor:
Anda Huna, Audrey Griveau, David Vindrieux, Sara Jaber, Jean-Michel Flaman, Delphine Goehrig, Lamia Azzi, Jean-Jacques Médard, Sophia Djebali, Hector Hernandez-Vargas, Robert Dante, Léa Payen, Jacqueline Marvel, Philippe Bertolino, Sébastien Aubert, Pierre Dubus, David Bernard
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-12 (2021)
Abstract Although aging is a major risk factor for most types of cancers, it is barely studied in this context. The transmembrane protein PLA2R1 (phospholipase A2 receptor) promotes cellular senescence, which can inhibit oncogene-induced tumor initia
Externí odkaz:
https://doaj.org/article/5df3bc9b126a40bd9a509fe79c7b7adf
Autor:
Layal Massara, Camille Khairallah, Nathalie Yared, Vincent Pitard, Benoit Rousseau, Julien Izotte, Alban Giese, Pierre Dubus, Xavier Gauthereau, Julie Déchanet-Merville, Myriam Capone
Publikováno v:
Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 250-261 (2020)
Human cytomegalovirus (HCMV) components are often found in tumors, but the precise relationship between HCMV and cancer remains a matter of debate. Pro-tumor functions of HCMV were described in several studies, but an association between HCMV seropos
Externí odkaz:
https://doaj.org/article/2586d72d7ac749f99b6ed62440713e98
Autor:
Silvia Elena Molina-Castro, Camille Tiffon, Julie Giraud, Hélène Boeuf, Elodie Sifre, Alban Giese, Geneviève Belleannée, Philippe Lehours, Emilie Bessède, Francis Mégraud, Pierre Dubus, Cathy Staedel, Christine Varon
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 257-276 (2020)
Background & Aims: Gastric carcinoma is related mostly to CagA+-Helicobacter pylori infection, which disrupts the gastric mucosa turnover and elicits an epithelial-mesenchymal transition (EMT) and preneoplastic transdifferentiation. The tumor suppres
Externí odkaz:
https://doaj.org/article/5f0b0c73c00e4cd0a7d97071ba0d863b
Autor:
Wencan He, Lamia Azzi-Martin, Valérie Velasco, Philippe Lehours, Pierre Dubus, Mojgan Djavaheri-Mergny, Armelle Ménard
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009320 (2021)
Humans are frequently exposed to bacterial genotoxins of the gut microbiota, such as colibactin and cytolethal distending toxin (CDT). In the present study, whole genome microarray-based identification of differentially expressed genes was performed
Externí odkaz:
https://doaj.org/article/5c8685e08cc747848f57097252ae7e29
Autor:
Patricia G. Santamaría, Pierre Dubus, José Bustos-Tauler, Alfredo Floristán, Alberto Vázquez-Naharro, Saleta Morales, Amparo Cano, Francisco Portillo
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5730 (2022)
Lysyl oxidase-like 2 (LOXL2) and 3 (LOXL3) are members of the lysyl oxidase family of enzymes involved in the maturation of the extracellular matrix. Both enzymes share a highly conserved catalytic domain, but it is unclear whether they perform redun
Externí odkaz:
https://doaj.org/article/0adf4ccbafa44263bcb32b994d0225e2